MicroRNA-101 suppresses migration and invasion via targeting vascular endothelial growth factor-C in hepatocellular carcinoma cells

Liu, Zhenyu; Wang, Jingjie; Mao, Yuqing; Zou, Bing; Fan, Xiaoming

doi:10.3892/ol.2015.3832

Cited by 29 publications

(22 citation statements)

References 33 publications

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“…Anti-VEGF treatment augments the tumor radiation response under normoxic or hypoxic conditions, which is a novel therapeutic strategy in cervical cancer (37). VEGFA and VEGFC, two members of the VEGF family, were recently identified as the predominant tumor metastasis-driving factors in various human cancers types, including renal cell carcinoma (38), hepatocellular carcinoma (39) and cervical cancer (40)(41)(42). The present study identified VEGFA and VEGFC as targets of miR-144 via directly binding to the 3'-UTRs of VEGFA and VEGFC mRNA in a dual luciferase reporter assay.…”

Section: Discussionmentioning

confidence: 99%

miR-144 inhibits growth and metastasis of cervical cancer cells by targeting VEGFA and VEGFC

et al. 2017

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Section: Discussionmentioning

confidence: 99%

miR-144 inhibits growth and metastasis of cervical cancer cells by targeting VEGFA and VEGFC

et al. 2017

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“…VEGF-C is an important and a major mediator of physiologic and pathogenic angiogenesis of HCC [29] . The knockdown of VEGF-C markedly inhibited invasion and migration of liver cancer cells [30] . Accordingly, EXT and isoepoxypteryxin treatment significantly reduced hepatic VEGF-C levels in TAA-induced HCC rat model.…”

Section: Table 1: Effect Of Different Group Treatment On Histopatholomentioning

confidence: 93%

Hepatoprotective Activities of the Methanol Extract of Angelica shikokiana and Isoepoxypteryxin against Hepatocellular Carcinoma

Mira¹,

Elsherbiny²,

Alkhiary³

et al. 2017

pharmaceutical-sciences

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JapanMira, et al.: Hepatoprotective Activity of Angelica shikokiana Angelica shikokiana (Apiaceae) is a Japanese traditional herb and widely marketed as a dietary food supplement as a health tea preparation consumed as a daily beverage for its health benefits. Our previous research showed that the methanol extract of the aerial parts of A. shikokiana and its major coumarin, isoepoxypteryxin had a significant cytotoxicity against HepG2 cell line. In this study, we investigated the hepatoprotective activity more deeply by the in vitro inhibition of HepG2 cells invasion assay and in vivo using thioacetamide-induced hepatocellular carcinoma model in rats. The ex vivo levels of nitric oxide production, inducible nitric oxide synthase, vascular endothelial cell growth factor-C and caspase-3 were also estimated to investigate the possible mechanisms of hepatoprotection. The methanol extract of A. shikokiana and isoepoxypteryxin concentration-dependently depressed the invasion of HepG2 cells induced by 12-O-tetradecanoylphorbol 13-acetate. In vivo, they significantly reduced the levels of alanine transaminase, aspartate transaminase, gamma-glutamyl transpeptidase, total bilirubin and nitric oxide production when compared with hepatocellular carcinoma group. Besides, the thioacetamide-injected groups treated with methanol extract of A. shikokiana and isoepoxypteryxin exhibited a significant increase in the level of caspase-3 protein and a significant decrease of inducible nitric oxide synthase and vascular endothelial cell growth factor C levels when compared with hepatocellular carcinoma group. To the best of our knowledge, this is the first report of the hepatoprotective effect of A. shikokiana and isoepoxypteryxin against hepatocellular carcinoma.

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“…Overexpression of miRNA-96 is observed in HBV-related HCC. In HCC cell lines, miRNA-101 targets VEGF-C resulting in the suppression of invasion [147]. miRNA-21 has been found upregulated in HCC and its degradation can be used as target in therapeutics [148].…”

Section: Noncoding Rnasmentioning

confidence: 99%

New Insights into the Epigenetics of Hepatocellular Carcinoma

Wahid

Ali

Rafique

et al. 2017

BioMed Research International

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Hepatocellular Carcinoma (HCC) is one of the most predominant malignancies with high fatality rate. This deadly cancer is rising at an alarming rate because it is quite resistant to radio- and chemotherapy. Different epigenetic mechanisms such as histone modifications, DNA methylation, chromatin remodeling, and expression of noncoding RNAs drive the cell proliferation, invasion, metastasis, initiation, progression, and development of HCC. These epigenetic alterations because of potential reversibility open way towards the development of biomarkers and therapeutics. The contribution of these epigenetic changes to HCC development has not been thoroughly explored yet. Further research on HCC epigenetics is necessary to better understand novel molecular-targeted HCC treatment and prevention. This review highlights latest research progress and current updates regarding epigenetics of HCC, biomarker discovery, and future preventive and therapeutic strategies to combat the increasing risk of HCC.

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MicroRNA-101 suppresses migration and invasion via targeting vascular endothelial growth factor-C in hepatocellular carcinoma cells

Abstract: Abstract. MicroRNAs (miRNAs) are a class of non-coding RNAs 18-25 nucleotides in length,

Cited by 29 publications

References 33 publications

miR-144 inhibits growth and metastasis of cervical cancer cells by targeting VEGFA and VEGFC

miR-144 inhibits growth and metastasis of cervical cancer cells by targeting VEGFA and VEGFC

Hepatoprotective Activities of the Methanol Extract of Angelica shikokiana and Isoepoxypteryxin against Hepatocellular Carcinoma

New Insights into the Epigenetics of Hepatocellular Carcinoma

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