Micronucleus induction after whole-body microwave irradiation of rats

Trošić, Ivančica; Bušljeta, Ivana; Kašuba, Vilena; Rozgaj, Ružica

doi:10.1016/s1383-5718(02)00214-0

Cited by 47 publications

(17 citation statements)

References 21 publications

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“…The time-course of PCE numbers, after a significant elevation at the beginning, indicates that an adaptive mechanism is involved in the proliferation and/or maturation process until the end of experiment. The results are consistent with findings on the influx of immature erythrocytes into the peripheral circulation after two irradiation treatments previously reported by Trosic et al (2002). The consequence of an accelerated exit of PCEs from bone marrow is a temporary imbalance in erythrocyte maturation and/or proliferation ( Figure 1 and Table I), which activates a known feedback mechanism of the homeostatic control system (Guyton, 2000).…”

Section: Discussionsupporting

confidence: 91%

Investigation of the genotoxic effect of microwave irradiation in rat bone marrow cells: in vivo exposure

Trošić

Bušljeta²,

Modlic³

2004

Mutagenesis

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Section: Discussionsupporting

confidence: 91%

Investigation of the genotoxic effect of microwave irradiation in rat bone marrow cells: in vivo exposure

Trošić

Bušljeta²,

Modlic³

2004

Mutagenesis

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“…In lymphocytes of persons previously subjected to intensive microwave irradiation by accident, the number of micronuclei is elevated (Garaj-Vrhovac, 1999). The micronuclei induction by microwaves has been shown by some researches (Trosic et al, 2002;Zotti-Martelli et al, 2005), but not in others (Zeni et al, 2003;Görlitz et al, 2005).…”

Section: Introductionmentioning

confidence: 97%

Effects of differently polarized microwave radiation on the microscopic structure of the nuclei in human fibroblasts

Shckorbatov¹,

Pasiuga²,

Goncharuk

et al. 2010

J. Zhejiang Univ. Sci. B

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Abstract:To investigate the influence of microwave radiation on the human fibroblast nuclei, the effects of three variants of electromagnetic wave polarization, linear and left-handed and right-handed elliptically polarized, were examined. Experimental conditions were: frequency (f) 36.65 GHz, power density (P) at the surface of exposed object 1, 10, 30, and 100 µW/cm 2 , exposure time 10 s. Human fibroblasts growing in a monolayer on a cover slide were exposed to microwave electromagnetic radiation. The layer of medium that covered cells during microwave exposure was about 1 mm thick. Cells were stained immediately after irradiation by 2% (w/v) orcein solution in 45% (w/v) acetic acid. Experiments were made at room temperature (25 °C), and control cell samples were processed in the same conditions. We assessed heterochromatin granule quantity (HGQ) at 600× magnification. Microwave irradiation at the intensity of 1 µW/cm 2 produced no effect, and irradiation at the intensities of 10 and 100 µW/cm 2 induced an increase in HGQ. More intense irradiation induced more chromatin condensation. The right-handed elliptically polarized radiation revealed more biological activity than the left-handed polarized one.

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“…In vitro and in vivo bioeffects resulting from RF exposure were reported and include changes in cell membrane functioning, major changes in calcium metabolism and cellular signal communication, in vitro and in vivo cell proliferation and differentiation, activation of protooncogenes, activation of heat shock proteins, and cell death (Saunders et al 1997;Cleary 1997;Fritze et al 1997;Leszczynski et al 2002;Hyland 2001;Trosic 2001;Trosic et al 2002Trosic et al , 2004aBusljeta et al 2004). The resulting effects include DNA breaks and chromosome aberrations, increased free radical production, cell stress, and premature aging (Lai & Singh 1996;Tice et al 2002).…”

Section: Introductionmentioning

confidence: 99%

Nocturnal urinary melatonin levels and urine biochemistry in microwave-irradiated rats

et al. 2009

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The aim of this study was to explore whether, during the course of a 15 days-lasting experiment, a two hours per day and five days per week, 2.45 GHz microwave whole-body irradiation may substantially and therefore provably affect rats' nocturnal urinary 6-hydroxy-melatonin sulphate (aMT6s) excretion and urinalysis parameters. The average whole-body specific absorption rate (SAR) equalled to 1.25 (± 0.36 SE) W/kg. To collect nocturnal urine samples, animals were held in individual metabolic cages every experimental night from 7:00 PM till 7:00 AM next day. The concentration of aMT6s in rat urine samples was determined by a direct radioimmunoassay. Bilirubin, ketones, and urine protein content have been determined via multiple-use reagent strips. In comparison to the sham-exposed group, no significant changes in body temperature and food or water intake were observed in the exposed group. A decline in aMT6s, determined in the exposed rats, was observed from day 8 to day 11 of the experiment (P < 0.05). The aMT6s level remained consistently low until the end of the experiment, but not significantly lower than the control values. The results of the urine samples biochemical workup failed to reveal any significant differences between the exposed and the control animal groups. The results of this study suggest that, under the above described experimental conditions, repeated 2.45 GHz irradiation could act as a stressor and therefore influence the melatonine balance in rat.

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Micronucleus induction after whole-body microwave irradiation of rats

Cited by 47 publications

References 21 publications

Investigation of the genotoxic effect of microwave irradiation in rat bone marrow cells: in vivo exposure

Investigation of the genotoxic effect of microwave irradiation in rat bone marrow cells: in vivo exposure

Effects of differently polarized microwave radiation on the microscopic structure of the nuclei in human fibroblasts

Nocturnal urinary melatonin levels and urine biochemistry in microwave-irradiated rats

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