Micronization of curcumin with biodegradable polymer by supercritical anti-solvent using micro swirl mixer

Chhouk, Kimthet; Diono, Wahyu; Kanda, Hideki; Kawasaki, Shin-ichiro; Goto, Motonobu

doi:10.1007/s11705-017-1678-3

Cited by 39 publications

(43 citation statements)

References 33 publications

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“…This can be ascribed to an intermolecular interaction, such as hydrogen bonding, between the O-H of curcumin and the C=O of PVP [16]. This behaviour is compatible with the observations of other researchers [16,39,73,74] and might explain the change in the structure of curcumin from crystalline to amorphous (sections 3.3 and 3.4) and the improvement in the aqueous apparent solubility (section 3.6) and dissolution properties of curcumin formulations (section 3.7).…”

Section: Fourier Transform Infrared Spectroscopy (Ftir)supporting

confidence: 91%

“…Although there are similarities between the SAS and ARISE processes in terms of the role of sc-CO 2 , differences between the mixing mechanism can lead to different results. The use of SAS process to produce CURC/PVP coprecipitates for pharmaceutical application has been reported once by Chhouk et al [39]. They used a micro-swirl mixer, a patented device, to process curcumin and PVP from a 90-10 acetone-ethanol mixture.…”

Section: Take Down Policymentioning

confidence: 99%

“…Therefore, it is clear that a deeper study and understanding of the coprecipitation of curcumin and PVP by SAS is necessary, which is the aim of this work. We also want to test if it is possible to obtain non-coalescing nanoparticles of the composite material, with high curcumin content (up to 25%) and improved dissolution properties, without the aid of a complex mixing device, as reported in the aforementioned work [39]. For the first time, different organic solvent mixtures were studied to understand how adjusting the solvent properties (solvation power) can modulate particle size and recovery of CURC/PVP coprecipitates.…”

Section: Take Down Policymentioning

confidence: 99%

“…Raw curcumin (CURC) presents an absorption band at 3504 cm -1 corresponding to O-H stretching vibration. Other peaks can be identified at 1626 cm -1 (C=O, C=C), 1601 cm -1 (C=C aromatic), 1427 cm -1 (C-O phenol), 1025 cm -1 (C-O-C), 960 cm -1 (benzoate trans-CH) and 855 cm -1 (C-H aromatic) [39,72]. The FTIR spectrum of PVP shows a peak at 3466 cm -1 assigned to the stretching vibration of O-H and other peaks at 2883, 1651 and 1284 cm -1 , corresponding to C-H, C=O and C-N, respectively [10,39].…”

Section: Fourier Transform Infrared Spectroscopy (Ftir)mentioning

confidence: 99%

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Coprecipitation of curcumin/PVP with enhanced dissolution properties by the supercritical antisolvent process

Matos

Prosapio

et al. 2019

Journal of CO2 Utilization

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The poor solubility of curcumin (CURC) in aqueous media leads to a low bioavailability, which prevents its application in pharmaceutical formulations. In this work, the Supercritical Antisolvent process (SAS) was used to produce coprecipitates of CURC and poly (vinyl pyrrolidone) (PVP) from mixtures of ethanol and acetone. The effects of operating parameters: pressure, temperature, solution concentration, drug/polymer mass ratio and solution flow rate were analysed for a 70-30 (v/v) acetone-ethanol mixture. It was found that the composition of acetone in the solvent mixture is the parameter that affects particle size and curcumin recovery the most. The thermal behaviour, crystallinity, molecular interactions, apparent solubility, release profile of the coprecipitates and possible degradation of curcumin were investigated. The results showed that the SAS process is effective in preparing amorphous formulations of CURC/PVP with an apparent solubility of more than 600 times higher than that of the physical mixture of the raw compounds.

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Section: Fourier Transform Infrared Spectroscopy (Ftir)supporting

confidence: 91%

Section: Take Down Policymentioning

confidence: 99%

Section: Take Down Policymentioning

confidence: 99%

Section: Fourier Transform Infrared Spectroscopy (Ftir)mentioning

confidence: 99%

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Coprecipitation of curcumin/PVP with enhanced dissolution properties by the supercritical antisolvent process

Matos

Prosapio

et al. 2019

Journal of CO2 Utilization

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“…It confirmed that the -carotene that dissolved in DCM solvent was not change after recrystallization process by SCCO2. Like the particle formation from other chemical compounds by SCCO2 antisolvent [24][25][26], the particles formation from -carotene solution by SCCO2 antisolvent may be affected by the feed solution concentration of -carotene injected in the SCCO2 antisolvent apparatus system. Fig.…”

Section: Resultsmentioning

confidence: 99%

Crystallization of All Trans–b–carotene by Supercritical Carbon Dioxide Antisolvent via Co–axial Nozzle

Kodama¹,

Honda²,

Machmudah³

et al. 2018

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The crystallization of -carotene through supercritical antisolvent process with carbon dioxide (CO2) as an antisolvent has been demonstrated. The experiments were conducted at temperatures of 40-60 o C and pressures of 10-14 MPa at a constant CO2 flow rate. As a starting material, -carotene powder was dissolved in dichloromethane (DCM). Results of UV-vis spectrophotometry and GC-MS analysis showed that there was no remaining DCM solvent in the -carotene particles products. It showed that CO2 has successfully removed DCM from -carotene particles products. The product characterization by using fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) showed that the CO2 solvent did not impregnate to the -carotene particles products. Results from scanning electron microscope (SEM) images showed that the -carotene particles products were successfully prepared in plate-like shape morphologies with size around 1 m.

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Fabrication of chitosan particles through a coaxial nozzle under pressurized carbon dioxide

Diono

Susilo

Machmudah

et al. 2020

Asia-Pacific J Chem Eng

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The generation of chitosan particles through supercritical carbon dioxide (SCCO2) antisolvent process was studied. The experiments were carried out at temperatures of 60–100°C and pressures of 15–25 MPa with a 15 ml min−1 CO2 flow rate. As a feed solution, chitosan powder was dissolved in acetic acid:water:ethanol. Scanning electron microscopy (SEM) observations described that the precipitated chitosan products have irregular morphologies with the spherical, the spherical with fiber‐like, and the fiber‐like free‐spherical particles. Interestingly, hollow‐core chitosan particles generated when SCCO2 antisolvent treatments were performed at a temperature of 60°C and pressures of 20–25 MPa. The Fourier transform infrared spectroscopy (FT‐IR) spectra indicated that the structural properties of chitosan did not shift after the SCCO2 antisolvent treatment. The results exhibited that this SCCO2 antisolvent technique is likely to be fruitful for the generation of biopolymer particles with hollow‐core structures.

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Micronization of curcumin with biodegradable polymer by supercritical anti-solvent using micro swirl mixer

Cited by 39 publications

References 33 publications

Coprecipitation of curcumin/PVP with enhanced dissolution properties by the supercritical antisolvent process

Coprecipitation of curcumin/PVP with enhanced dissolution properties by the supercritical antisolvent process

Crystallization of All Trans–b–carotene by Supercritical Carbon Dioxide Antisolvent via Co–axial Nozzle

Fabrication of chitosan particles through a coaxial nozzle under pressurized carbon dioxide

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