Microfluidic Tissue Engineering and Bio‐Actuation

Filippi, Miriam; Büchner, Thomas; Yaşa, Öncay; Weirich, Stefan; Katzschmann, Robert K.

doi:10.1002/adma.202108427

Cited by 33 publications

(28 citation statements)

References 443 publications

(779 reference statements)

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“…The in vitro microfluidic platforms enable the investigation of distinctive biological pathways by mimicking the principal aspects in natural tissues and organs [ 248 , 328 ]. Thus, several applications of microfluidic platforms in tissue engineering were realized and are discussed in this review as two topics—replication of cellular microenvironment and fabrication of biomaterials [ 329 ].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…Therefore, it is crucially important to replicate the dynamics of the cellular microenvironment to analyze the phenotypes for disease modelling and therapeutics. Herein, microfluidic platforms are favorable to construct complex biofidelic cell microenvironments by precisely altering the distribution of oxygen and signaling molecules, controlling the mechanotransduction, and presenting a way to combine them with elements to induce the cells electrically, chemically, or mechanically [ 329 ]. The cellular behavior depends on the flow.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…The vascularization is one of the obstacles in tissue engineering, and it is considered an essential process to equally distribute the nutrients and oxygen successfully in engineered tissues [ 346 ]. In this regard, microfluidic platforms play a crucial role in intensifying the inherent laminar flow and perfusion flow through cells for vasculogenesis and represent a unique system for microvessels perfusion [ 329 , 347 ]. In a recent study, Wang et al developed a microfluidics-based technique for the fabrication of the endothelized biomimetic microvessels (BMVs) by alginate–collagen composites [ 348 ].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

See 2 more Smart Citations

Biomedical Applications of Microfluidic Devices: A Review

et al. 2022

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Both passive and active microfluidic chips are used in many biomedical and chemical applications to support fluid mixing, particle manipulations, and signal detection. Passive microfluidic devices are geometry-dependent, and their uses are rather limited. Active microfluidic devices include sensors or detectors that transduce chemical, biological, and physical changes into electrical or optical signals. Also, they are transduction devices that detect biological and chemical changes in biomedical applications, and they are highly versatile microfluidic tools for disease diagnosis and organ modeling. This review provides a comprehensive overview of the significant advances that have been made in the development of microfluidics devices. We will discuss the function of microfluidic devices as micromixers or as sorters of cells and substances (e.g., microfiltration, flow or displacement, and trapping). Microfluidic devices are fabricated using a range of techniques, including molding, etching, three-dimensional printing, and nanofabrication. Their broad utility lies in the detection of diagnostic biomarkers and organ-on-chip approaches that permit disease modeling in cancer, as well as uses in neurological, cardiovascular, hepatic, and pulmonary diseases. Biosensor applications allow for point-of-care testing, using assays based on enzymes, nanozymes, antibodies, or nucleic acids (DNA or RNA). An anticipated development in the field includes the optimization of techniques for the fabrication of microfluidic devices using biocompatible materials. These developments will increase biomedical versatility, reduce diagnostic costs, and accelerate diagnosis time of microfluidics technology.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Section: Biomedical Applicationsmentioning

confidence: 99%

Section: Biomedical Applicationsmentioning

confidence: 99%

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Biomedical Applications of Microfluidic Devices: A Review

et al. 2022

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“…Purely synthetic microrobots are made of synthetic materials only, and their actuation results from a combination of applied magnetic forces and propellant designs. Bio-hybrid robots are robots that contain a biological living component [303,304]. In bio-hybrid robots, this component is represented by cells endowed with self-propulsion ability.…”

Section: Magnetic Guidance Of Microrobotsmentioning

confidence: 99%

“…Robots with a biological living component that actively contributes to the movement of the whole assembly are referred to as bio-hybrid robots [304]. Bio-hybrid microrobots use natural biological actuation for propulsion.…”

Section: Bio-hybrid Microrobotsmentioning

confidence: 99%

Micro/Nanosystems for Magnetic Targeted Delivery of Bioagents

et al. 2022

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Targeted delivery of pharmaceuticals is promising for efficient disease treatment and reduction in adverse effects. Nano or microstructured magnetic materials with strong magnetic momentum can be noninvasively controlled via magnetic forces within living beings. These magnetic carriers open perspectives in controlling the delivery of different types of bioagents in humans, including small molecules, nucleic acids, and cells. In the present review, we describe different types of magnetic carriers that can serve as drug delivery platforms, and we show different ways to apply them to magnetic targeted delivery of bioagents. We discuss the magnetic guidance of nano/microsystems or labeled cells upon injection into the systemic circulation or in the tissue; we then highlight emergent applications in tissue engineering, and finally, we show how magnetic targeting can integrate with imaging technologies that serve to assist drug delivery.

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Bioinspired Superwetting Open Microfluidics: From Concepts, Phenomena to Applications

et al. 2023

Adv Funct Materials

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Microfluidics and bioinspired superwetting materials, as two crucial branches of scientific research, are entering their golden age of development. As an emerging interdisciplinary subject of these two fields, bioinspired superwetting open microfluidics is triggering technological revolutions in many disciplines, including rapid medical diagnosis, biochemical analysis, liquid manipulation, 3D printing, etc. However, this new research area has yet to attract extensive attention. So, a timely review is necessary to organize the development process, summarize current achievements, and discuss the challenges or chances for the ongoing scientific trend. In this review, the evolution from closed to open microfluidics is combed first. Then, three typical bioinspired superwetting systems are introduced emphatically. Based on this, the bioinspired superwetting open microfluidics is divided into different categories according to the bionic objects as the focus of this study. Taking natural phenomena as the entry point, the research from the underlying mechanism to the application is systematically discussed and summarized. Several emerging applications are also mentioned. Finally, some views on major problems, existing challenges, and developing trends are briefly put forward in this field to guide future research.

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Microfluidic Tissue Engineering and Bio‐Actuation

Cited by 33 publications

References 443 publications

Biomedical Applications of Microfluidic Devices: A Review

Biomedical Applications of Microfluidic Devices: A Review

Micro/Nanosystems for Magnetic Targeted Delivery of Bioagents

Bioinspired Superwetting Open Microfluidics: From Concepts, Phenomena to Applications

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