2016
DOI: 10.1016/j.jcis.2016.04.010
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Microfluidic synthesis of dye-loaded polycaprolactone-block-poly(ethylene oxide) nanoparticles: Insights into flow-directed loading and in vitro release for drug delivery

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Cited by 32 publications
(63 citation statements)
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“…The restricted volume allows to limit the diffusion distance of solvent and antisolvent, therefore it regulates the mixing of the two liquids that can be further controlled by modification of stream flow rates or chip design [53][54][55][56]. The fine control over this process results in tunability of the NP properties, such as its size, surface characteristics or crystallinity [57][58][59]. It reduces batch-to-batch variability and enables the investigation on how the NPs properties can be tailored upon formulation parameters, what was not possible within the bulk mixing method [45,60,61].…”
Section: Introductionmentioning
confidence: 99%
“…The restricted volume allows to limit the diffusion distance of solvent and antisolvent, therefore it regulates the mixing of the two liquids that can be further controlled by modification of stream flow rates or chip design [53][54][55][56]. The fine control over this process results in tunability of the NP properties, such as its size, surface characteristics or crystallinity [57][58][59]. It reduces batch-to-batch variability and enables the investigation on how the NPs properties can be tailored upon formulation parameters, what was not possible within the bulk mixing method [45,60,61].…”
Section: Introductionmentioning
confidence: 99%
“…The morphologies of amphiphilic block copolymers self-assembled in a gas-liquid microfluidic reactor are entirely different from off-chip equilibrium structures [145]. Moffitt's group has intensively studied the fascinating effects of high-shear environments in segmented gas-liquid microfluidic reactors on the self-assembly of block copolymers (Figure 12a) [146][147][148]. Figure 12d).…”
Section: Structured Nanoparticlesmentioning
confidence: 99%
“…Due to the high shear at high flow rates, the copolymer chains self-assembled into spherical nanocomposites instead of into lamellae that are generated at low shear. The specific morphologies, such as spool generated from the shear control, have been employed to manipulate the loading and releasing speeds of drugs and dyes by the group of Matthew G. Moffitt [85,86]. Compared to single-phase microfluidic reactors, the shear force induced by segment movements and internal recirculation is another unique property of compartments for creating various nanomaterial morphologies.…”
Section: Reaction Within Compartments Of Taylor and Bubbly Flowmentioning
confidence: 99%