Microfluidic synthesis of amorphous cefuroxime axetil nanoparticles with size-dependent and enhanced dissolution rate

Wang, Jie‐Xin; Zhang, Qianxia; Zhou, Yunshan; Shao, Lei; Chen, Jianfeng

doi:10.1016/j.cej.2010.06.022

Cited by 61 publications

(28 citation statements)

References 39 publications

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“…In response, several studies have investigated a number of techniques to enhance drug solubility (Aldawsari et al, 2013;Charoenchaitrakool et al, 2000;Chen et al, 2015;Fujimori et al, 2015;Sanphui et al, 2011;Serajuddin, 2007;Wang et al, 2010). Nonetheless, a number of compounds have great potential applicability in co-crystallization due to the existence of non-covalent bonds between molecules in co-crystals.…”

Section: Introductionmentioning

confidence: 98%

Kinetics of co-crystal formation with caffeine and citric acid via liquid-assisted grinding analyzed using the distinct element method

Shimono

Kadota

Tozuka

et al. 2015

European Journal of Pharmaceutical Sciences

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Section: Introductionmentioning

confidence: 98%

Kinetics of co-crystal formation with caffeine and citric acid via liquid-assisted grinding analyzed using the distinct element method

Shimono

Kadota

Tozuka

et al. 2015

European Journal of Pharmaceutical Sciences

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“…Some examples of nanoprecipitation using different kinds of microfluidic devices can be found in the literature, such as amorphous cefuroxime axetil prepared by nanoprecipitation to enhance the dissolution rate, using a Y-junction microreactor [21] and a T-junction microreactor [22]. The authors observed that the total fluid flow rate, the antisolvent to solvent flow rate The manuscript was received on July 31, 2013; revision received on September 2, 2013; accepted on September 3, 2013 ratio, and the cefuroxime concentration, all influence particle size.…”

Section: Introductionmentioning

confidence: 99%

LTCC-3D Coaxial Flow Focusing Microfluidic Reactor for Micro and Nanoparticle Fabrication and Production Scale-Out

Gongora-Rubio¹,

Schianti²,

Gomez³

et al. 2013

Journal of Microelectronics and Electronic Packaging

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AbstractÀMiniaturization of chemical processes is becoming a must for green chemistry and sustainable industry processes, so technological research in this direction is well received. Continuous microreactor systems hold many potential benefits over batch reactors, in that they allow: high surface-to-volume ratio, fine adjustment of chemical reaction residence times, small thermal inertia, and fast changes in temperature. Advantages of multilayer green ceramics for microprocess applications include: that the LTCC substrate is chemically inert to most solvents, that it has a high contact angle, that it presents low thermal coefficient of expansion, and that it can withstand high operational temperatures and high internal pressures. For these reasons, LTCC-based microsystem technologies allow the implementation of different unitary operations for chemical processes, making it an enabling technology for the miniaturization of chemical processes. In fact, recently, LTCC microfluidic reactors have been used to produce microparticles and nanoparticles with excellent control of size distribution and morphology. The present work provides a report on the performance of a 3D LTCC coaxial flow focusing microfluidic reactor designed to fabricate microparticles and nanoparticles using nanoprecipitation through an antisolvent; with electric potential size tuning. We also implement an approach to particle production scale-out.

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“…In another study, it was shown that design of microreactor and processing conditions may have an influence on the hydrocortisone particle size during nanoprecipitation using microfluidic reactors (18). Also, microfluidic nanoprecipitation of the other pharmaceutical ingredients such as danazol (20), norfloxacin (15), cefuroxime axetil (16), and rifampicin (17) have shown the creation of drug particles with controlled sizes, improved dissolution rate, continuous synthesis, and amorphous profile.…”

Section: Introductionmentioning

confidence: 99%

“…Effects of changing the various parameters of the microfluidic precipitation process, including flow rate of drug solution and antisolvent, drug saturation level, channels internal diameter, microreactor inlet angle, drug concentration, precipitation temperature, and surfactant concentration, on the size of nanosized drug particles have been evaluated widely in previous studies (15)(16)(17)(18)(19)(20). It is observed that increasing in the flow rate of antisolvent and decreasing in the flow rate of drug solution, sharpen inlet angles and lessen saturation levels resulted in smaller particle sizes (19).…”

Section: Introductionmentioning

confidence: 99%

Size Control in the Nanoprecipitation Process of Stable Iodine (127I) Using Microchannel Reactor—Optimization by Artificial Neural Networks

et al. 2015

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Abstract. In this study, nanosuspension of stable iodine ( 127 I) was prepared by nanoprecipitation process in microfluidic devices. Then, size of particles was optimized using artificial neural networks (ANNs) modeling. The size of prepared particles was evaluated by dynamic light scattering. The response surfaces obtained from ANNs model illustrated the determining effect of input variables (solvent and antisolvent flow rate, surfactant concentration, and solvent temperature) on the output variable (nanoparticle size). Comparing the 3D graphs revealed that solvent and antisolvent flow rate had reverse relation with size of nanoparticles. Also, those graphs indicated that the solvent temperature at low values had an indirect relation with size of stable iodine ( 127 I) nanoparticles, while at the high values, a direct relation was observed. In addition, it was found that the effect of surfactant concentration on particle size in the nanosuspension of stable iodine ( 127 I) was depended on the solvent temperature.

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Microfluidic synthesis of amorphous cefuroxime axetil nanoparticles with size-dependent and enhanced dissolution rate

Cited by 61 publications

References 39 publications

Kinetics of co-crystal formation with caffeine and citric acid via liquid-assisted grinding analyzed using the distinct element method

Kinetics of co-crystal formation with caffeine and citric acid via liquid-assisted grinding analyzed using the distinct element method

LTCC-3D Coaxial Flow Focusing Microfluidic Reactor for Micro and Nanoparticle Fabrication and Production Scale-Out

Size Control in the Nanoprecipitation Process of Stable Iodine (127I) Using Microchannel Reactor—Optimization by Artificial Neural Networks

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