Microfluidic room temperature ionic liquid droplet generation depending on the hydrophobicity and interfacial tension

Hwang, Jung Wook; Choi, Joo-Hyung; Choi, Boyoon; Lee, Gyudo; Lee, Sang Woo; Koo, Yoon‐Mo; Chang, Woo-Jin

doi:10.1007/s11814-015-0037-7

Cited by 8 publications

(3 citation statements)

References 27 publications

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“…Recently, microfluidic systems that generate monodisperse droplets provide a promising alternative for the synthesis of monodisperse emulsions and microparticles. 36,37 One advantage of microfluidic methods is the ability to control the size of the droplets by manipulating the flow rate of the dispersed and continuous fluid as well as the geometry of the microchannels. 15,[38][39][40] Moreover, this approach offers the ability to minimize the reaction time, reduce the reagents, and provide rapid mass and heat transfer and high-throughput screening.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of thermosensitive gelatin hydrogel microspheres in a microfluidic system

et al. 2016

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We present a simple synthetic approach for the preparation of monodisperse thermosensitive gelatin microspheres in a microfluidic system. Based on the mechanism of shear force-driven break-off, aqueous droplets of a gelatin solution were continuously produced in an immiscible continuous fluid. Under cooling conditions, the gelatin droplets solidified into hydrogel microspheres, which resulted from the aggregation or crystallization of collagen folds. The produced gelatin microspheres possess a high monodispersity and fast response to environmental temperature. In addition, the size of the prepared microspheres can be manipulated by altering the flow rate of the continuous phase or aqueous phase, and the physical strength of the gelatin microspheres can be controlled by simply changing the gelatin concentration. Furthermore, this approach enables the preparation of monodisperse microspheres with the ability to exhibit different thermosensitivities and encapsulate colloidal particles under mild conditions, which demonstrate sequential release of the desired encapsulants according to the responsive temperature.

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Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of thermosensitive gelatin hydrogel microspheres in a microfluidic system

et al. 2016

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“…Although membrane separators have already showcased the power to separate diverse solvents (e.g., toluene and water), their ability to tackle ionic liquids remains untapped. Compared with those organic solvents, ILs are often remarkably more challenging to separate from the washing agent due to high viscosity (20–97000 mPa·s) and low interfacial tension (∼10 dyn/cm for BMIM-NTf 2 and aqueous solution). , …”

Section: Introductionmentioning

confidence: 99%

Purification of Ionic Liquid Solvents in a Self-Optimizing, Continuous Microfluidic Process via Extraction of Metal Ions and Phase Separation

Pan

Karadaghi

Brutchey

et al. 2022

ACS Sustainable Chem. Eng.

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Industrial applications of ionic liquids (ILs)solvents that can serve as green alternatives to volatile organic compoundsare often hampered by their high cost. Solvent recycling provides a feasible pathway to recover IL solvents to reduce lifecycle costs. Herein, we demonstrate a continuous microfluidic process to purify metal-ion-loaded IL solvents, wherein Fe(III) ions are extracted from a prototypical IL, 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (BMIM-NTf2), to deionized (DI) water with subsequent membrane separation of the IL and aqueous phases. Inline analytical tools, design of experiment statistical optimization, and a self-optimizing, modified Nelder-Mead simplex algorithm facilitate locating the best parametric operating conditions to optimize both ion extraction and physical phase separation. This process was then adapted to a more challenging purification application: recovery of the IL trihexyl(tetradecyl)phosphonium bis(2,4,4-trimethyl-pentyl)phosphinate (Cyphos 104) from the rare-earth metal Nd(III). This application demonstrated that optimized conditions obtained from a single stage could be applied across a multistage process. Together, these results demonstrate that statistical and inline optimization tools can be used to identify working parameters for different flow systems with a variety of governing fluid properties, for example, viscosity and interfacial tension.

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“…Recently, we have reported several microfluidic static droplet arrays (SDA) as a universal analytical platform by combining hydrodynamics and microvalve technology for generation, manipulation, analysis, and retrieval of multiple microdroplets in parallel. [27][28][29][30] This SDA is able to analyse at the single-cell level in real time since it deals with static droplets with fixed positions. In addition, selective release and retrieval of desired droplets encapsulating cells and reusability of the system are also attractive features as a screening method.…”

Section: Introductionmentioning

confidence: 99%

On-chip analysis, indexing and screening for chemical producing bacteria in a microfluidic static droplet array

et al. 2016

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Economic production of chemicals from microbes necessitates development of high-producing strains and an efficient screening technology is crucial to maximize the effect of the most popular strain improvement method, the combinatorial approach. However, high-throughput screening has been limited for assessment of diverse intracellular metabolites at the single-cell level. Herein, we established a screening platform that couples a microfluidic static droplet array (SDA) and an artificial riboswitch to analyse intracellular metabolite concentration from single microbial cells. Using this system, we entrapped single Escherichia coli cells in SDA to measure intracellular l-tryptophan concentrations. It was validated that intracellular l-tryptophan concentration can be evaluated by the fluorescence from the riboswitch. Moreover, high-producing strains were successfully screened from a mutagenized library, exhibiting up to 145% productivity compared to its parental strain. This platform will be widely applicable to strain improvement for diverse metabolites by developing new artificial riboswitches.

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Microfluidic room temperature ionic liquid droplet generation depending on the hydrophobicity and interfacial tension

Cited by 8 publications

References 27 publications

Synthesis and characterization of thermosensitive gelatin hydrogel microspheres in a microfluidic system

Synthesis and characterization of thermosensitive gelatin hydrogel microspheres in a microfluidic system

Purification of Ionic Liquid Solvents in a Self-Optimizing, Continuous Microfluidic Process via Extraction of Metal Ions and Phase Separation

On-chip analysis, indexing and screening for chemical producing bacteria in a microfluidic static droplet array

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