Microfluidic paper-based chemiluminescence biosensor for simultaneous determination of glucose and uric acid

Yu, Jinghua; Ge, Lei; Huang, Jiadong; Wang, Shoumei; Ge, Shenguang

doi:10.1039/c0lc00524j

Cited by 300 publications

(174 citation statements)

References 54 publications

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“…4 Paper based chemiluminescence biosensors for the simultaneous detection and quantification of glucose and uric acid in artificial urine have already been demonstrated. 5 Other useful features of paper based sensing devices or fuel cells are low cost, ease of use and disposal, and low consumption of reagents. Therefore, paper based fuel cells are viable alternatives to battery operated MNSs for the former are not only cheap, but are also made up of less toxic components.…”

Section: Introductionmentioning

confidence: 99%

Low Cost Environmentally Benign Porous Paper Based Fuel Cells for Micro-Nano Systems

Lal

Janardhanan

Deepa

et al. 2015

J. Electrochem. Soc.

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This work deals with the development of a paper based fuel cell for application in micro-nano systems. In this cell, a porous paper serves as a transport medium and eliminates the need for any metering devices that are integral to conventional fuel cells. Since only very small flow rates of reagents can be achieved on paper, these cells produce only a few milli-watts of power. In this work, formic acid is used as the fuel and potassium permanganate is used as the oxidant. Since the cell presented here is membraneless, both formic acid and potassium permanganate are mixed with sulfuric acid, and they form the anolyte and the catholyte, respectively. A special cell geometry has been designed and implemented to minimize and delay the fuel and oxidant cross over effects. In order to keep the cost low, graphite sheets without † patent application based on the results presented here has been filed through

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Section: Introductionmentioning

confidence: 99%

Low Cost Environmentally Benign Porous Paper Based Fuel Cells for Micro-Nano Systems

Lal

Janardhanan

Deepa

et al. 2015

J. Electrochem. Soc.

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“…自 2007 年 whitesides 组 [1] 首次提出这个概念以来, 纸芯片因其原料廉价易得、易加工、生物兼容性好、无需外力驱动液流等特点受到了科研工作者极大的关注, 在临床医学诊断, 食品安全检测以及环境质量监控等多个领域展现了巨大的应用前景. 近几年来, 文献相继报道了紫外光处理 [1 ～ 4] 、蜡印 [5,6] 、溶剂刻蚀 [7,8] 、等离子体处理 [9] [16,17] 、化学发光法 [18,19] 和电化学法 [20,21] 等. 本文参照文献 [17], 利用 Trinder 反应所得显色产物的颜色深浅对血液中葡萄糖含量进行测定.…”

Section: 引言unclassified

Fabrication of Paper-based Microfluidic Devices by Plasma Treatment and Its Application in Glucose Determination

Yan¹,

Yu²,

Jiang³

et al. 2014

Acta Chim. Sinica

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Currently, various methods for fabricating microfluidic paper-based analytical devices (μPADs) have been proposed due to their great potential applications in many fields such as clinical diagnosis, food quality control and environmental monitoring. Hereby, a novel and simple method for the fabrication of microfluidic paper-based analytical devices via plasma treatment is reported. Paper was first hydrophobized via octadecyltrichlorosilane (OTS) silanization. The OTS silanized paper was then region-selectively plasma-treated via a mask with channel network. The plasma-exposed area of the paper was turned to hydrophilic channel network due to the degradation of hydrophobic OTS molecules coupled to the paper's cellulose fibres before. Two types of hybrid polymethylmethacrylate-polydimethylsiloxane (PMMA-PDMS) masks were developed to obtain well defined hydrophilic channel with the required depth. With the elastic PDMS piece adhered to the rigid PMMA piece, it excellently solved the problem of the expansion of hydrophilic channel caused by the leakage of plasma atmosphere in the gap between the mask and paper. The effect of plasma-treating time on hydrophilicity of paper was investigated. The water contact angle (WCA) dramatically decreased from 133.9°±1.3° to 0° with the prolonging of the plasma treating time from 0 s to 30 s. Meanwhile, the depth of wettable channel could also increase to nearly the thickness (180 μm) of the paper after treated for 30 s. Attenuated total reflectance Fourier transformed infrared (ATR-FT-IR) spectrometer and X-ray photoelectron spectroscopy (XPS) were applied to characterize the surface chemistry of paper during silanization and plasma treatment, and the related mechanism was discussed. The fabricated μPAD was applied for detection of plasma glucose in whole blood. After diluted with 2% NaCl by a ratio of 1∶4, plasma could be separated from blood cells due to their different mobility in the channel on paper. The separated plasma reached test readout zone and reacted with the substrates of Trinder's reaction. The analytical results observed with the μPAD-based colorimetric assays agreed well with those determined by conventional glucose meter.

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“…However, they have not been widely used in paper-based microfluidics; only a few studies investigated using these two detection methods for detecting analytes in paper-based microfluidic devices or paper-based microarray plates. 16,19,41 Figure 5(c) shows an approach of conducting ECL detection on paper-based microfluidic devices.…”

Section: The Application Of Paper-based Microfluidic Devicesmentioning

confidence: 99%

A perspective on paper-based microfluidics: Current status and future trends

2012

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“Paper-based microfluidics” or “lab on paper,” as a burgeoning research field with its beginning in 2007, provides a novel system for fluid handling and fluid analysis for a variety of applications including health diagnostics, environmental monitoring as well as food quality testing. The reasons why paper becomes an attractive substrate for making microfluidic systems include: (1) it is a ubiquitous and extremely cheap cellulosic material; (2) it is compatible with many chemical/biochemical/medical applications; and (3) it transports liquids using capillary forces without the assistance of external forces. By building microfluidic channels on paper, liquid flow is confined within the channels, and therefore, liquid flow can be guided in a controlled manner. A variety of 2D and even 3D microfluidic channels have been created on paper, which are able to transport liquids in the predesigned pathways on paper. At the current stage of its development, paper-based microfluidic system is claimed to be low-cost, easy-to-use, disposable, and equipment-free, and therefore, is a rising technology particularly relevant to improving the healthcare and disease screening in the developing world, especially for those areas with no- or low-infrastructure and limited trained medical and health professionals. The research in paper-based microfluidics is experiencing a period of explosion; most published works have focused on: (1) inventing low-cost and simple fabrication techniques for paper-based microfluidic devices; and (2) exploring new applications of paper-based microfluidics by incorporating efficient detection methods. This paper aims to review both the fabrication techniques and applications of paper-based microfluidics reported to date. This paper also attempts to convey to the readers, from the authors’ point of view the current limitations of paper-based microfluidics which require further research, and a few perspective directions this new analytical system may take in its development.

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Microfluidic paper-based chemiluminescence biosensor for simultaneous determination of glucose and uric acid

Cited by 300 publications

References 54 publications

Low Cost Environmentally Benign Porous Paper Based Fuel Cells for Micro-Nano Systems

Low Cost Environmentally Benign Porous Paper Based Fuel Cells for Micro-Nano Systems

Fabrication of Paper-based Microfluidic Devices by Plasma Treatment and Its Application in Glucose Determination

A perspective on paper-based microfluidics: Current status and future trends

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