Microfluidic controlling monodisperse microdroplet for 5-fluorouracil loaded genipin-gelatin microcapsules

Huang, Keng‐Shiang; Lu, Kang; Yeh, Chen-Sheng; Chung, Shu Ru; Lin, Che-Hsin; Yang, Chih Hui; Dong, Yu Shun

doi:10.1016/j.jconrel.2009.02.019

Cited by 89 publications

(45 citation statements)

References 64 publications

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“…In the present study, there were reductions in inner cavity diameter with increasing polymer load. This is in agreement with the findings of Huang et al, who demonstrated that 5-FU release in miCAPs formulated from chondroitin sulphate and chitosan was decreased by increasing polymer concentration [21].…”

Section: Discussionsupporting

confidence: 93%

“…The chromatograms of pure GA and the prepared miCAPs were recorded and compared, to ensure absence of unreacted GA. Sharp intense peaks were present at different retention times while these peaks were completely absent in chromatogram of the miCAP formulations, indicating the absence of unreacted GA. This is in agreement with results obtained in previous studies in which the absence of unreacted GA was confirmed by gas chromatography [21,25]. …”

Section: Effect Of Micap Formation On the Fourier Infrared Spectra Ofsupporting

confidence: 93%

See 1 more Smart Citation

Development and <i>in vitro</i> characterization of 5-flurouracilloaded, colon-targeted drug delivery system

Raza¹,

Ranjha²,

Mahmood³

et al. 2018

Trop. J. Pharm Res

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Section: Discussionsupporting

confidence: 93%

Section: Effect Of Micap Formation On the Fourier Infrared Spectra Ofsupporting

confidence: 93%

Development and <i>in vitro</i> characterization of 5-flurouracilloaded, colon-targeted drug delivery system

Raza¹,

Ranjha²,

Mahmood³

et al. 2018

Trop. J. Pharm Res

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“…Researchers have used genipin to crosslink a variety of materials including, but not limited to: bovine serum albumin (BSA), chitosan, gelatin, gelatin-carrageenan mixtures, soy proteins and whey proteins for purposes including: wound dressings, hydrogels and micro/nanoparticles and films (Butler et al 2003;Annan et al 2008;Huang et al 2009;Devi and Maji 2010). To our knowledge, there has been little work on its affinity to legume proteins and potential for use in stabilizing emulsions.…”

Section: Affinity Of Genipin To the Legume Protein Isolatesmentioning

confidence: 99%

“…Genipin forms inter-and intra-molecular covalent bonds with primary amine groups (e.g., lysine) so as to modify protein structure (Butler et al 2003). Genipin has been extensively used to crosslink a variety of proteins including but not limited to: gelatin, bovine serum albumin (BSA), whey and gelatin-carrageenan mixtures (Butler et al 2003;Annan et al 2008;Huang et al 2009;Devi and Maji 2010).…”

Section: Introductionmentioning

confidence: 99%

The physicochemical properties of legume protein isolates and their ability to stabilize oil-in-water emulsions with and without genipin

2014

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The physicochemical and emulsifying properties of legume protein isolates prepared from chickpea (CPI), faba bean (FPI), lentil (LPI) and soy (SPI) were investigated in the presence and absence of genipin. Solubility was highest for CPI (~94 %), followed by LPI (~90 %), FPI (~85 %) and SPI (~50 %). Surface characteristics revealed similar zeta potentials (~−47 mV) for CPI, LPI and FPI, but lower for SPI (~− 44 mV). Contrastingly, surface hydrophobicity was greatest for CPI (~137 arbitrary units, AU), followed by SPI/LPI (~70 AU) and FPI (~24 AU). A significant (from 16.73 tõ 8.42 mN/m) reduction in interfacial tension was observed in canola oil-water mixtures in the presence of non-crosslinked legume protein isolates. The extent of legume protein isolategenipin crosslinking was found to be similar for all isolates. Overall, creaming stability increased in the presence of genipin, with maximum stability observed for SPI (65 %), followed by FPI (61 %), LPI (56 %) and finally CPI (50 %).

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“…For this purpose, attempts have been focused on the development of drug delivery systems containing antineoplastic drugs. Huang et al (2009) studied in vitro release of 5-FU from genipin-gelatin microcapsules. They reported that uniform genipin-gelatin microcapsules would provide many potential usages for pharmaceutical applications.…”

Section: Introductionmentioning

confidence: 99%

Preparation of ferric ion crosslinked acrylamide grafted poly (vinyl alcohol)/sodium alginate microspheres and application in controlled release of anticancer drug 5-fluorouracil

Şanlı

Olukman

2013

Drug Delivery

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Ionically crosslinked microspheres of acrylamide (AAm) grafted poly (vinyl alcohol) (PVA)/ sodium alginate (NaAlg) were prepared by crosslinking with FeCl 3 and 5-fluorouracil (5-FU), which is an anticancer drug and was successfully encapsulated into the microspheres. The graft copolymer (PVA-g-PAAm) was characterized by using Fourier transform infrared spectroscopy (FTIR) and elemental analysis. The prepared microspheres were characterized by FTIR and scanning electron microscopy (SEM). Microspheres were also characterized by particle diameter, equilibrium swelling values and release profiles. The release studies were carried out at three pH values 1.2, 6.8 and 7.4, respectively, each for 2 h. The effects of preparation conditions as PVA-g-PAAm/NaAlg ratio, drug/polymer ratio, crosslinker concentration and exposure time to FeCl 3 on the release of 5-FU were investigated for 6 h at 37 C. The highest 5-FU release was found to be as 99.57% (w/w) at the end of 6 h for PVA-g-PAAm/NaAlg ratio of 1:4 (w/w), drug/ polymer ratio of 1:8 (w/w), crosslinker concentration of 0.05 M and exposure time of 10 min. The release results were also supported by the swelling measurements of the microspheres. Release kinetics was described by Fickian and non-Fickian approaches.

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Microfluidic controlling monodisperse microdroplet for 5-fluorouracil loaded genipin-gelatin microcapsules

Cited by 89 publications

References 64 publications

Development and <i>in vitro</i> characterization of 5-flurouracilloaded, colon-targeted drug delivery system

Development and <i>in vitro</i> characterization of 5-flurouracilloaded, colon-targeted drug delivery system

The physicochemical properties of legume protein isolates and their ability to stabilize oil-in-water emulsions with and without genipin

Preparation of ferric ion crosslinked acrylamide grafted poly (vinyl alcohol)/sodium alginate microspheres and application in controlled release of anticancer drug 5-fluorouracil

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