Preparation of ferric ion crosslinked acrylamide grafted poly (vinyl alcohol)/sodium alginate microspheres and application in controlled release of anticancer drug 5-fluorouracil
Abstract:Ionically crosslinked microspheres of acrylamide (AAm) grafted poly (vinyl alcohol) (PVA)/ sodium alginate (NaAlg) were prepared by crosslinking with FeCl 3 and 5-fluorouracil (5-FU), which is an anticancer drug and was successfully encapsulated into the microspheres. The graft copolymer (PVA-g-PAAm) was characterized by using Fourier transform infrared spectroscopy (FTIR) and elemental analysis. The prepared microspheres were characterized by FTIR and scanning electron microscopy (SEM). Microspheres were also… Show more
“…Spherical shaped particles were formed by Mg 2+ and Ca 2+ , whereas Sr 2+ and Ba 2+ produced nonspherical particles. Transformation of microspheres is shown by SEM as [46]. Microspheres were characterized by particle diameter, equilibrium swelling values and morphology, elemental analysis, and release profiles.…”
Section: Effect Of Divalent Cation On Morphology and Drug-delivery Efficiencymentioning
confidence: 99%
“…Microspheres of acrylamide- (AAm-) grafted poly(vinyl alcohol) (PVA)/sodium alginate (NaAlg) were prepared by crosslinking with FeCl 3 and 5-fluorouracil (5-FU) [ 46 ]. Microspheres were characterized by particle diameter, equilibrium swelling values and morphology, elemental analysis, and release profiles.…”
Alginate is one of the natural polymers that are often used in drug- and protein-delivery systems. The use of alginate can provide several advantages including ease of preparation, biocompatibility, biodegradability, and nontoxicity. It can be applied to various routes of drug administration including targeted or localized drug-delivery systems. The development of alginates as a selected polymer in various delivery systems can be adjusted depending on the challenges that must be overcome by drug or proteins or the system itself. The increased effectiveness and safety of sodium alginate in the drug- or protein-delivery system are evidenced by changing the physicochemical characteristics of the drug or proteins. In this review, various routes of alginate-based drug or protein delivery, the effectivity of alginate in the stem cells, and cell encapsulation have been discussed. The recent advances in the in vivo alginate-based drug-delivery systems as well as their toxicities have also been reviewed.
“…Spherical shaped particles were formed by Mg 2+ and Ca 2+ , whereas Sr 2+ and Ba 2+ produced nonspherical particles. Transformation of microspheres is shown by SEM as [46]. Microspheres were characterized by particle diameter, equilibrium swelling values and morphology, elemental analysis, and release profiles.…”
Section: Effect Of Divalent Cation On Morphology and Drug-delivery Efficiencymentioning
confidence: 99%
“…Microspheres of acrylamide- (AAm-) grafted poly(vinyl alcohol) (PVA)/sodium alginate (NaAlg) were prepared by crosslinking with FeCl 3 and 5-fluorouracil (5-FU) [ 46 ]. Microspheres were characterized by particle diameter, equilibrium swelling values and morphology, elemental analysis, and release profiles.…”
Alginate is one of the natural polymers that are often used in drug- and protein-delivery systems. The use of alginate can provide several advantages including ease of preparation, biocompatibility, biodegradability, and nontoxicity. It can be applied to various routes of drug administration including targeted or localized drug-delivery systems. The development of alginates as a selected polymer in various delivery systems can be adjusted depending on the challenges that must be overcome by drug or proteins or the system itself. The increased effectiveness and safety of sodium alginate in the drug- or protein-delivery system are evidenced by changing the physicochemical characteristics of the drug or proteins. In this review, various routes of alginate-based drug or protein delivery, the effectivity of alginate in the stem cells, and cell encapsulation have been discussed. The recent advances in the in vivo alginate-based drug-delivery systems as well as their toxicities have also been reviewed.
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