Microemboli Monitoring in Ischemic Stroke

Idicula, Titto; Thomassen, Lars

doi:10.5772/26032

Cited by 2 publications

(1 citation statement)

References 66 publications

(91 reference statements)

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“…The value of the analysis with regard to neurovascular safety is a relevant topic for discussion with potential clinical significance (Gascou et al 2014). It is clear that many common surgical and endovascular procedures are associated with microemboli traveling to the brain (Rapp et al 2003; Idicula and Thomassen 2012; Moody et al 1995). Neurovascular intervention is presumably no exception.…”

Section: Vasospasm and Vascular Injury: Confounding Histopathologicalmentioning

confidence: 99%

Pathological Safety Assessment in Preclinical Neurothrombectomy Studies

Spangler¹,

Katzman

2019

Toxicol Pathol

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The design, production, and preclinical testing of neurothrombectomy devices is in a burgeoning phase as the demand escalates for safe and reliable treatment options following neurovascular stroke. Currently, there is a paucity of published data describing the development of iatrogenic vascular lesions occurring secondary to neurothrombectomy procedures. In an effort to test new devices, demonstrate device safety, satisfy regulatory requirements, and develop an understanding of the potential for associated vascular pathology, investigators are establishing appropriate methodology in suitable animal models. Significant challenges exist in identifying a single animal species that can be consistently utilized in all phases of device development. These aforementioned challenges are underscored by the intricacies of neurovascular pathology, thrombovascular interactions, and vascular responses to injury.

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Section: Vasospasm and Vascular Injury: Confounding Histopathologicalmentioning

confidence: 99%

Pathological Safety Assessment in Preclinical Neurothrombectomy Studies

Spangler¹,

Katzman

2019

Toxicol Pathol

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Pre-clinical investigations of multi-path propagation in transcranial Doppler ultrasound flow phantom

Weir

Wang

Parks

2016

2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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There are various practical situations in medical applications when pre-clinical investigations must be performed using a simulation environment or test bench prior to human studies. One example is the analysis of propagation channels in Transcanial Doppler (TCD) ultrasound (US), a signal processing challenge requiring the analysis of data from US waves scattered in three dimensions (3D). When examining the effects of scatterers in such channels, it is common to use a data acquisition test bench and a Doppler flow phantom. Such medical phantoms are frequently required to verify image and signal processing systems, and are often used to support algorithm development for a wide range of imaging and blood flow assessments. In this paper we describe a TCD simulation environment for the acquisition, investigation and pre-clinical data analysis of multi-path propagation in TCD US systems. This is demonstrated by comparing the anticipated theoretical and simulation channel statistics with the measured acoustic characteristics in terms of the probability distribution and autocorrelation functions.

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Microemboli Monitoring in Ischemic Stroke

Cited by 2 publications

References 66 publications

Pathological Safety Assessment in Preclinical Neurothrombectomy Studies

Pathological Safety Assessment in Preclinical Neurothrombectomy Studies

Pre-clinical investigations of multi-path propagation in transcranial Doppler ultrasound flow phantom

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