Microcystic Adnexal Carcinoma of the Eyebrow

Ong, Tuyen; Liew, S. H.; Mulholland, B.; Davis, Peyton; Calonje, Eduardo

doi:10.1097/01.iop.0000117339.03172.17

Cited by 14 publications

(17 citation statements)

References 14 publications

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“…The tumor has been known by several other names in the past, including: sclerosing sweat duct carcinoma, malignant syringoma, sweat gland carcinoma with syringomatous features, aggressive trichofolliculoma, and combined adnexal tumor of the skin. As a rare tumor, with just over 300 cases reported worldwide since its initial description, it is difficult to generalize the small case series and reports to the population at large (2–31). In this article, we review what is known about the clinical presentation and behavior of MAC over time, histologic characteristics, and therapeutic options available as well as what therapy is currently recommended.…”

Section: Introductionmentioning

confidence: 99%

Microcystic adnexal carcinoma: a diagnostic and therapeutic challenge

Wetter

Goldstein

2008

Dermatologic Therapy

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Microcystic adnexal carcinoma (MAC) is a rare cutaneous neoplasm that is often diagnosed after having been present for a significant period of time. It appears bland on histologic evaluation despite its locally aggressive behavior. Actual skin involvement is significantly more extensive than can be determined clinically and because of this, therapy is challenging. Though metastasis is rare, there have been reports of both regional and distant metastatic disease. Several treatment modalities have been used to date, including standard excision (SE), Mohs micrographic surgery (MMS), irradiation, chemotherapy, and observation. There has also been discussion in the literature regarding techniques than can aid in assurance of clear margins with MMS. We review the literature on MAC, including the various therapeutic options, addressing when one modality may be preferable over others. In general, MMS offers the highest likelihood of clear margins and cure with the fewest procedures.

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Section: Introductionmentioning

confidence: 99%

Microcystic adnexal carcinoma: a diagnostic and therapeutic challenge

Wetter

Goldstein

2008

Dermatologic Therapy

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“…Including our case, at least 274 cases of MAC have been reported 5–28 . It is usually found on the head and neck and especially the central face area 29,30 .…”

Section: Discussionmentioning

confidence: 81%

Microcystic Adnexal Carcinoma Involving a Large Portion of the Face: When Is Surgery Not Reasonable?

Eisen

Zloty

2005

Dermatologic Surgery

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“…The factors common to our patients in whom tumor persisted after MMS (Patients B and D) were previous treatment, periocular site, and PNI. The periocular area is a common site for MAC, although this has been reported to account for less than 1.0% of all eyelid tumors 20 . Periocular MAC may be difficult to diagnose because diagnostic biopsies are usually small at this site.…”

Section: Discussionmentioning

confidence: 99%

“…The periocular area is a common site for MAC, although this has been reported to account for less than 1.0% of all eyelid tumors. 20 Periocular MAC may be difficult to diagnose because diagnostic biopsies are usually small at this site. Clement and colleagues reported three cases of periocular MAC treated using MMS and reviewed all other cases (n = 35) published in the English language literature.…”

Section: Table 1 Characteristics Of Patients With Microcystic Adnexamentioning

confidence: 99%