Microcystic Adnexal Carcinoma

Abstract

MMS with frozen sections is reliable for treating primary MAC in which PNI is not present on a diagnostic biopsy. Previous surgery and PNI were associated with greater risk of persistence in periocular MAC. In these patients, it may be appropriate to consider MMS with paraffin-embedded sections, possibly as a layer after apparent clearance on frozen sections. Further excision of orbital contents should be considered in periocular MAC that infiltrate the deep orbital fat or are noted to have PNI.

Sclerosing sweat duct carcinoma of the lower extremity treated with Mohs micrographic surgery

“… 12 Pathologic “skip areas” 13 , 14 perineural invasion, 12 , 15 and the misinterpretation of atypical epithelioid structures as normal 16 are thought to contribute to this observance. Most SSDC recurrences occur within 2 years after treatment, 4 , 16 whereas others happen decades later. 17 Careful surveillance of tumor sites postoperatively is recommended.…”

“… 17 Careful surveillance of tumor sites postoperatively is recommended. Metastasis from SSDC is rare 16 , 18 with one death reported in an immunocompromised host. 12 …”

Desmoplastic Trichoepithelioma: Histopathologic and Immunohistochemical Criteria for Differentiation of a Rare Benign Hair Follicle Tumor From Other Cutaneous Adnexal Tumors

“…It exhibits both follicular and ductal differentiation and is presumed to arise from a pluripotent adnexal keratinocyte with a preference for the head and neck [35][36][37][38][39]. It is a sluggish, deeply infiltrative, and locally invasive tumor with a high affinity for perineural intrusion [40,41]. Histologically, tumors frequently have a benign appearance, especially the superficial parts, which can prompt misdiagnosis as a syringoma or a benign follicular neoplasm [41,42].…”

“…It is a sluggish, deeply infiltrative, and locally invasive tumor with a high affinity for perineural intrusion [40,41]. Histologically, tumors frequently have a benign appearance, especially the superficial parts, which can prompt misdiagnosis as a syringoma or a benign follicular neoplasm [41,42].…”

Evidence-Based Clinical Practice Guidelines for Management of Microcystic Adnexal Carcinoma

“…Finally, close clinical followup by a doctor familiar with MAC is advised every 6 to 12 months for the first 5 years after treatment to monitor for local recurrence and distant metastasis. 4,5 We thank the authors for their review; it has provided valuable guidelines for management of this rare tumor.…”