Microchip gas chromatography columns, interfacing and performance

Ghosh, Abhijit; Vilorio, Carlos R.; Hawkins, Aaron R.; Lee, Milton L.

doi:10.1016/j.talanta.2018.04.088

Cited by 42 publications

(31 citation statements)

References 146 publications

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“…Nonetheless, compared to conventional capillary columns, µ-columns are several magnitudes shorter, noncylindrical, and normally microfabricated on top of planar substrates, using a chip-based configuration [ 228 ]. The separation performance of µ-columns will depend on the optimization of several factors, such as: (i) channel cross-section (e.g., rectangular, square, trapezoidal, or semicircular), (ii) channel design (e.g., circular or square spiral, serpentine, zigzag, radiator, or wavy), (iii) column typology (e.g., open, semipacked, or monolithic columns), (iv) substrate material, (v) stationary phase, (vi) operating temperatures, (vii) flow rate, and (viii) carrier gas [ 229 ]. Metal, glass polymers, and silicon-based materials are the most common substrates used in µ-columns, due to their good physical, thermal, and chemical properties [ 230 ].…”

Section: Microanalytical Tools For Vocs Discriminationmentioning

confidence: 99%

Advancements in Microfabricated Gas Sensors and Microanalytical Tools for the Sensitive and Selective Detection of Odors

Ollé

Farré-Lladós

Casals‐Terré

2020

Sensors

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In recent years, advancements in micromachining techniques and nanomaterials have enabled the fabrication of highly sensitive devices for the detection of odorous species. Recent efforts done in the miniaturization of gas sensors have contributed to obtain increasingly compact and portable devices. Besides, the implementation of new nanomaterials in the active layer of these devices is helping to optimize their performance and increase their sensitivity close to humans’ olfactory system. Nonetheless, a common concern of general-purpose gas sensors is their lack of selectivity towards multiple analytes. In recent years, advancements in microfabrication techniques and microfluidics have contributed to create new microanalytical tools, which represent a very good alternative to conventional analytical devices and sensor-array systems for the selective detection of odors. Hence, this paper presents a general overview of the recent advancements in microfabricated gas sensors and microanalytical devices for the sensitive and selective detection of volatile organic compounds (VOCs). The working principle of these devices, design requirements, implementation techniques, and the key parameters to optimize their performance are evaluated in this paper. The authors of this work intend to show the potential of combining both solutions in the creation of highly compact, low-cost, and easy-to-deploy platforms for odor monitoring.

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Section: Microanalytical Tools For Vocs Discriminationmentioning

confidence: 99%

Advancements in Microfabricated Gas Sensors and Microanalytical Tools for the Sensitive and Selective Detection of Odors

Ollé

Farré-Lladós

Casals‐Terré

2020

Sensors

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“…Micro-gas chromatography (μGC) systems have shown immense growth in the last two decades [ 1 , 2 , 3 , 4 , 5 ]. It provides a less invasive option for gas analysis that can be monitored in real time and offer reliable quantitative data in essential sectors, including industry, healthcare, environment, and national security.…”

Section: Introductionmentioning

confidence: 99%

A Portable Micro-Gas Chromatography with Integrated Photonic Crystal Slab Sensors on Chip

et al. 2021

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The miniaturization of gas chromatography (GC) systems has made it possible to utilize the analytical technique in various on-site applications to rapidly analyze complex gas samples. Various types of miniaturized sensors have been developed for micro-gas chromatography (µGC). However, the integration of an appropriate detector in µGC systems still faces a significant challenge. We present a solution to the problem through integration of µGC with photonic crystal slab (PCS) sensors using transfer printing technology. This integration offers an opportunity to utilize the advantages of optical sensors, such as high sensitivity and rapid response time, and at the same time, compensate for the lack of detection specificity from which label-free optical sensors suffer. We transfer printed a 2D defect free PCS on a borofloat glass, bonded it to a silicon microfluidic gas cell or directly to a microfabricated GC column, and then coated it with a gas responsive polymer. Realtime spectral shift in Fano resonance of the PCS sensor was used to quantitatively detect analytes over a mass range of three orders. The integrated µGC–PCS system was used to demonstrate separation and detection of a complex mixture of 10 chemicals. Fast separation and detection (4 min) and a low detection limit (ng) was demonstrated.

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“…First, the solute concentration development in the stationary phase of microchannel has not been explicitly illustrated in the literature, and thus a key to unlock the characteristics of the solute dispersion in the mobile phase of the microchannel is missing. Second, the axial symmetry of the solute concentration distribution at the microchannel outlet is crucial for achieving high-resolution and high-sensitivity on-site separation/detection [2,37,38]. Former studies only focused on the solute dispersion coefficient, which quantifies the extent of solute dispersion in the microchannel, while an in-depth investigation of the asymmetry (i.e., skewness) of solute distribution at the microchannel outlet is rare.…”

Section: Introductionmentioning

confidence: 99%

Numerical investigation of the solute dispersion in finite‐length microchannels with the interphase transport

Zhang

Qian

et al. 2020

Electrophoresis

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This paper utilizes a combined approach of the convection‐diffusion theory and the moment analysis to conduct a comprehensive investigation of the solute dispersion under the influence of the interphase transport in finitely long inner coated microchannels. The present work has threefold novel contributions: (1) The 2D solute concentration contours in the stationary phase are calculated for the first time to facilitate the understanding the role of the interphase transport in the solute dispersion in the mobile phase. (2) The skewness of the elution curves is investigated to guide the control of solute band shape at the channel outlet. (3) The 2D diffusion‐convection theory and zero‐dimensional (0D) moment analysis complement each other to present a characterization of the solute dispersion behaviors more comprehensive than that by either of the two methods alone. Parametric studies are performed to clarify the effects of four major parameters related to the interphase transport (i.e., stationary phase Péclet number, interphase transport rate, partition coefficient, and stationary phase thickness) on the solute dispersion characteristics. The results from this study provide a straightforward understanding of the effects of interphase transport on the solute dispersion in finitely long microchannels and are of potential relevance to the design and operation of the microfluidics‐based analytical devices.

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Microchip gas chromatography columns, interfacing and performance

Cited by 42 publications

References 146 publications

Advancements in Microfabricated Gas Sensors and Microanalytical Tools for the Sensitive and Selective Detection of Odors

Advancements in Microfabricated Gas Sensors and Microanalytical Tools for the Sensitive and Selective Detection of Odors

A Portable Micro-Gas Chromatography with Integrated Photonic Crystal Slab Sensors on Chip

Numerical investigation of the solute dispersion in finite‐length microchannels with the interphase transport

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