A Portable Micro-Gas Chromatography with Integrated Photonic Crystal Slab Sensors on Chip

Biswas, Priyanka; Zhang, Chen; Chen, Yudong; Liu, Zhonghe; Vaziri, Seyedmohsen; Zhou, Weidong; Sun, Yuze

doi:10.3390/bios11090326

Cited by 22 publications

(12 citation statements)

References 56 publications

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“…Although this approach works well in some cases [ 11 ], such filters or traps may eliminate target molecules as well as the interfering gases. The use of a preconcentrator and micro-gas chromatography are other approaches for detecting low-concentration VOCs from interfering gases [ 12 , 13 , 14 ]. This approach, however, often requires a temperature control unit in the measurement system and a long measurement time, resulting in a complicated measurement protocol.…”

Section: Introductionmentioning

confidence: 99%

Repetitive Direct Comparison Method for Odor Sensing

2023

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Olfactory sensors are one of the most anticipated applications of gas sensors. To distinguish odors—complex mixtures of gas species, it is necessary to extract sensor responses originating from the target odors. However, the responses of gas sensors tend to be affected by interfering gases with much higher concentrations than target odor molecules. To realize practical applications of olfactory sensors, extracting minute sensor responses of odors from major interfering gases is required. In this study, we propose a repetitive direct comparison (rDC) method, which can highlight the difference in odors by alternately injecting the two target odors into a gas sensor. We verified the feasibility of the rDC method on chocolates with two different flavors by using a sensor system based on membrane-type surface stress sensors (MSS). The odors of the chocolates were measured by the rDC method, and the signal-to-noise ratios (S/N) of the measurements were evaluated. The results showed that the rDC method achieved improved S/N compared to a typical measurement. The result also indicates that sensing signals could be enhanced for a specific combination of receptor materials of MSS and target odors.

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Section: Introductionmentioning

confidence: 99%

Repetitive Direct Comparison Method for Odor Sensing

2023

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“…In addition, ethanol sensors also play an important role in detecting drunk driving [7]. Currently, gas detection technology includes gas chromatography [8], quartz crystal microbalance [9], and TDLAS detection technology [10]. However, real-time monitoring of ethanol is achieved by chemiresistive sensors with the advantages of easy preparation, low cost, and portability [11,12].…”

Section: Introductionmentioning

confidence: 99%

NiO-Based Gas Sensors for Ethanol Detection: Recent Progress

Zeng

2022

Journal of Sensors

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In this review, we summarized the state-of-the-art progress on the ethanol performance of NiO by means of morphology, doping, loading noble metal particles, and forming heterojunctions. We first introduced the effect of modulating NiO morphology on ethanol performance that has been reported in recent years. The morphology with large specific surface area and high porosity was considered to be the one that can bring high gas response. Then, we discussed the enhanced effect of the doping of metal cations and noble metal particle loading on the ethanol-sensitive properties of NiO. Doping ions increased the ground-state resistance and increased the oxygen defect concentration of NiO. The effects of noble metal particles on the performance of NiO included chemical sensitization and electronic sensitization. Finally, the related contents of NiO forming complexes with metal oxides and bimetallic oxides were discussed. In this section, the specific improvement mechanism was discussed first, and then, the related work of researchers in recent years was summarized. At the same time, we presented a reasonable outlook for NiO-based ethanol sensors, imagining future directions.

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“…Low cost and low resource micro/nano sensors was developed on flexible substrates by Bamshad et al [18]. Photonic crystal slab (PCS) was developed to investigate complex gases at ng level detection by Biswas et al [19]. Analysis of single-cell was performed with the help of the microfluidic system integrated electrical impedance by Kim et al [20].…”

Section: Introductionmentioning

confidence: 99%

An electrochemical biosensor with integrated microheater to improve the sensitivity of electrochemical nucleic acid biosensors

Akcakoca¹,

Ghorbanpoor²,

Blair³

et al. 2022

J. Micromech. Microeng.

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Electrochemical impedance spectroscopy (EIS) is often used for biomolecular detection based on the interaction of a molecule with a receptor functionalised electrode surface and consequent impedance change. Though its performance is well established, there is still a need for improved sensitivity and specificity, especially when attempting to detect nucleic acids from clinical samples with minimal amplification steps. Localised heating is a potential approach for improving nucleic hybridisation rates and reducing non-specific interactions, and thereby producing high sensitivity and selectivity [1-3]. The aim of the study was therefore to develop a microheater surrounding Au thin film electrodes, an integrated hybrid chip, for detecting genes of Mycobacterium tuberculosis with enhanced sensitivity. The performance of the integrated hybrid chip was determined using the changes in the charge transfer resistance (Rct) upon DNA hybridisation using probe sequences for Mycobacterium tuberculosis. Heat transfer within the system was simulated by using COMSOL Multiphysics as a mathematical modelling tool. When a temperature of 50 °C was applied to the microheater during DNA hybridisation steps, Rct values (which were indicative of DNA-DNA hybridisation) increased 236% and 90% as opposed to off-chip non-heated experiments and off-chip heated experiments. It is concluded from these observations that the microheater indeed can significantly improve the performance of the nucleic acid hybridisation assay and paves the way for the development of highly- sensitive and specific integrated label-free biosensors.

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A Portable Micro-Gas Chromatography with Integrated Photonic Crystal Slab Sensors on Chip

Cited by 22 publications

References 56 publications

Repetitive Direct Comparison Method for Odor Sensing

Repetitive Direct Comparison Method for Odor Sensing

NiO-Based Gas Sensors for Ethanol Detection: Recent Progress

An electrochemical biosensor with integrated microheater to improve the sensitivity of electrochemical nucleic acid biosensors

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