Microbiota potential for the treatment of sexual dysfunction

Tirandaz, Hassan; Ebrahim-Habibi, Mohammad-Bagher; Moradveisi, Borhan; Raoofi, Saeid; Salehi-Najafabadi, Amir; Mohammadi, Ebrahim

doi:10.1016/j.mehy.2018.03.021

Cited by 12 publications

(5 citation statements)

References 47 publications

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“…Importantly, finasteride withdrawal can also affect the gut microbiota composition in PFS patients [ 11 ] and its experimental model [ 8 ]. Therefore, because (i) sexual dysfunction may be related to alterations in gut microbiota [ 67 , 68 , 69 , 70 ] and (ii) the existence of the well-described gut-brain axis [ 9 , 10 ], observations here obtained may provide an important background to explore, with this experimental model, the protective effect of ALLO on psychiatric and andrological dysfunctions, laying the groundwork for possible therapy in PFS patients.…”

Section: Discussionmentioning

confidence: 99%

Gut Inflammation Induced by Finasteride Withdrawal: Therapeutic Effect of Allopregnanolone in Adult Male Rats

et al. 2022

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The treatment with finasteride (i.e., an inhibitor of 5α-reductase) may be associated with different side effects (i.e., depression, anxiety, cognitive impairment and sexual dysfunction) inducing the so-called post finasteride syndrome (PFS). Moreover, previous observations in PFS patients and an experimental model showed alterations in gut microbiota populations, suggesting an inflammatory environment. To confirm this hypothesis, we have explored the effect of chronic treatment with finasteride (i.e., for 20 days) and its withdrawal (i.e., for 1 month) on the levels of steroids, neurotransmitters, pro-inflammatory cytokines and gut permeability markers in the colon of adult male rat. The obtained data demonstrate that the levels of allopregnanolone (ALLO) decreased after finasteride treatment and after its withdrawal. Following the drug suspension, the decrease in ALLO levels correlates with an increase in IL-1β and TNF-α, serotonin and a decrease in dopamine. Importantly, ALLO treatment is able to counteract some of these alterations. The relation between ALLO and GABA-A receptors and/or pregnenolone (ALLO precursor) could be crucial in their mode of action. These observations provide an important background to explore further the protective effect of ALLO in the PFS experimental model and the possibility of its translation into clinical therapy.

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Section: Discussionmentioning

confidence: 99%

Gut Inflammation Induced by Finasteride Withdrawal: Therapeutic Effect of Allopregnanolone in Adult Male Rats

et al. 2022

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“…Another explanation, as Yurkovetskiy et al discovered, is that the microbiota may both positively and negatively regulate sex hormone levels depending on host physiology, strain, and other factors. 58 As the function of sex steroids in the gut to affect the function of the gastrointestinal system has been progressively recognized, it has also been clear that some gut microbiota have the ability to express steroid-processing enzymes and produce steroid hormones. Diviccaro et al found that levels of T metabolites, including DHT, 3α-diol, and…”

Section: Gut Microbiome and Sexual Hormonesmentioning

confidence: 99%

“…Another explanation, as Yurkovetskiy et al. discovered, is that the microbiota may both positively and negatively regulate sex hormone levels depending on host physiology, strain, and other factors 58 …”

Section: Gut Microbiome and Male Infertilitymentioning

confidence: 99%

Exploring the role of gut microbiome in male reproduction

Wang

Zuo-gang

2022

Andrology

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Background The impact of the gut microbiome on the organism has become a growing research focus with the development of 16S rRNA sequencing. However, the effect of the gut microbiome in male reproduction has yet to be investigated. Objective To overview on possible mechanisms by which the gut microbiome could affect male reproduction and therapeutic opportunities related to the gut microbiome Methods Authors searched PubMed/MEDLINE, EMBASE, Web of Science, and Cochrane Library for medical subject headings terms and free text words referred to “male infertility” “testis” “gut microbiome” “insulin resistance” “erectile dysfunction” “therapy” “sex hormones” and “genital diseases” until December 2, 2021. Results Evidence suggests that immune system activation caused by the gut microbiome translocation not only leads to testicular and epididymal inflammation but can also induce insulin resistance together with gastrointestinal hormones such as leptin and ghrelin, which in turn affects the secretion of various sex hormones such as LH, FSH, and T to regulate spermatogenesis. In addition, the gut microbiome can influence spermatogenesis by controlling and metabolizing androgens as well as affecting the blood–testis barrier. It also promotes vascular inflammation by raising trimethylamine‐N‐oxide (TMAO) levels in the blood, which causes erectile dysfunction. The testicular microbiome and gut microbiome can interact to influence male reproductive function. This study discusses therapeutic options such as probiotics, prebiotics, and fecal microbiota transplantation, as well as the challenges and opportunities behind ongoing research, and emphasizes the need for additional research in the future to demonstrate the links and underlying mechanisms between the gut microbiome and male reproduction. Therapeutic options such as probiotics, prebiotics, and fecal microbiota transplantation are potential treatments for male infertility. Discussion and conclusion Gut microbiota may have a causal role in male reproduction health, therapeutic strategies such as supplementation with appropriate probiotics could be undertaken as a complementary treatment. In the future, additional research is needed to demonstrate the links and underlying mechanisms between the gut microbiome and male reproduction.

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“…Tirandaz et al [37] have assumed that there is a substantial potential of gut microbiota and treatment of sexual dysfunction. This hypothesis is based on a strong evidence that sexual problems are affected negatively by hormonal disturbances, stress, obesity, hypertension, and diabetes.…”

Section: Effects Of Probiotics On Oxidative Stress Testosterone Levementioning

confidence: 99%

Probiotics and the envisaged role in treating human infertility

Younis

Mahasneh

2020

Middle East Fertil Soc J

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Background Considerable attention is being directed nowadays towards using probiotics as an alternative therapy in treating several human diseases including gastrointestinal tract diseases especially colorectal cancers, cardiovascular diseases, hyperlipidemia, and blood pressure cases. However, infertility as affected by the microbiome and the probable role of probiotics in alleviating infertility problems did not receive the deserved attention, especially in IVF patients with male or female factors. Main body In this review, we tried to draw the attention of researchers in the medical settings to the importance of the forthcoming role of probiotics use in elucidating the role of the microbiome in infertile patients. The hope is to attain the best performance of both male and female reproductive systems and to shed some light on infertility problems. Conclusion More in vivo experiments are still needed to address many aspects of probiotics like proper administration, exact functional strains, required dose, application method, duration of treatment, and combination with antibiotics before considering probiotics as an alternative treatment.

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Microbiota potential for the treatment of sexual dysfunction

Cited by 12 publications

References 47 publications

Gut Inflammation Induced by Finasteride Withdrawal: Therapeutic Effect of Allopregnanolone in Adult Male Rats

Gut Inflammation Induced by Finasteride Withdrawal: Therapeutic Effect of Allopregnanolone in Adult Male Rats

Exploring the role of gut microbiome in male reproduction

Probiotics and the envisaged role in treating human infertility

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