“…It has been suggested that a defective gut barrier function can end with the dissemination within the blood flow of microbial-associated molecular patterns (MAMPs) such as lipopolysaccharide, lipoprotein acids, peptidoglycans, and lipoproteins into the testis and epididymis. Indeed, immune system activation, induced by GM translocation, leads to testicular and epididymal inflammation and, also, triggers insulin resistance together with gastrointestinal hormones which, in turn, affect the secretion of sex hormones [luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone (T)] and their role in the regulation of spermatogenesis [ 89 ].…”