Microbiological Systems in Organic Synthesis: Preparation of Racemic Prenalterol Utilizing Cunninghamella echinulata

Biphenyl oxide hydroxylation by Cunninghamella echinulata

“…corymbiferum (CMPG 208), and Ulocladium botrytis (CMPG 148). C. echinulata (CMPG 668) has been widely used to introduce a hydroxy group into aromatic substrates (Pasutto et al, 1987). Biological oxidation of aromatic structures may be a detoxification process or it may represent a step in the partial or total consumption of a substrate.…”

“…Although extensive work has been done on biphenyl (Dodge et al, 1979;Wiseman et al, 1975;Cox and Golbeck, 1985), no study was concerned with microbial hydroxylation of biphenyl oxide. Studies suggested that Cunninghamella echinulata effectively parahydroxylated some synthetic substrates (Pasutto et al, 1987). The possible toxicity of biphenyl oxide toward previously selected fungal strains (Chapelle et al, 1986) has been checked and the bioconversion of biphenyl oxide investigated under various culture conditions.…”