Microbiological species and antimicrobial resistance profile in patients with diabetic foot infections

Oliveira, Alexandre Faraco de; Filho, Horácio de Oliveira

doi:10.1590/1677-5449.0015

Cited by 12 publications

(7 citation statements)

References 13 publications

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“…The best specimens for analysis by culture would be collected from deep tissues free from contamination or necrosis, since collections from superficial tissues can reduce the number of pathogens isolated, resulting in monomicrobial cultures. 24 Finally, limitations at the microbiology laboratory used should also be considered, since it cannot perform cultures of obligate anaerobes. Cultures for facultative anaerobes are primarily ordered in osteomyelitis cases.…”

Section: Discussionmentioning

confidence: 99%

Fatores de risco para mortalidade em pacientes submetidos a amputações maiores por pé diabético infectado

et al. 2018

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Resumo Contexto A lesão no pé de pacientes com diabetes é um importante problema de saúde pública que frequentemente está associado a amputações em membros inferiores e mortalidade nessa população. Objetivos Investigar os fatores de risco associados a mortalidade em pacientes com pé diabético infectado submetidos a amputação maior. Métodos Estudo observacional, retrospectivo e caso-controle. Amostra composta por 78 pacientes com pé diabético e úlcera infectada submetidos a amputação maior em um serviço de cirurgia vascular em um hospital universitário no período de 5 anos. Resultados A média de idade da amostra estudada foi de 63,8 ± 10,5 anos, com 54 (69,2%) pacientes do sexo masculino, com creatinina sérica média de 2,49 ± 2,4 mg/dL e hemoglobina sérica média de 7,36 ± 1,7 g/dL. Houve 47,4% de reinternação. Foi realizada amputação transtibial em 59,0% e transfemoral em 39,7% da amostra estudada. Nesta amostra, 87,2% dos pacientes apresentaram cultura positiva, predominantemente monomicrobiana (67,9%), e 30,8% apresentaram infecção hospitalar da úlcera. Os gêneros de bactérias mais frequentes foram Acinetobacter spp. (24,4%), Morganella spp. (24,4%) e Proteus spp. (23,1%). Nenhum gênero bacteriano foi identificado como fator de risco para óbito. O nível de creatinina ≥ 1,3 mg/dL (OR 17,8; IC 2,1-150) e a amputação transfemoral (OR 4,5; IC: 1,3-15,7) foram fatores de risco para o óbito. Conclusões Os níveis séricos de creatinina ≥ 1,3 mg/dL e amputação transfemoral foram fatores de risco para óbito.

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Section: Discussionmentioning

confidence: 99%

Fatores de risco para mortalidade em pacientes submetidos a amputações maiores por pé diabético infectado

et al. 2018

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“…However, it should be noted that clindamycin is also used for anaerobic organisms but we did not examine such organisms in this study. In a study conducted in 2014, it was shown that combination use of these antibiotics does not lead to the desired result [ 48 ]. In addition, high rate of resistance to ciprofloxacin was noted by other studies [ 34 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

Isolation and Antibiotic Susceptibility of the Microorganisms Isolated from Diabetic Foot Infections in Nemazee Hospital, Southern Iran

Anvarinejad

Pouladfar

Japoni

et al. 2015

Journal of Pathogens

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Background. Diabetic foot infections (DFIs) are a major public health issue and identification of the microorganisms causing such polymicrobial infections is useful to find out appropriate antibiotic therapy. Meanwhile, many reports have shown antibiotic resistance rising dramatically. In the present study, we sought to determine the prevalence of microorganisms detected on culture in complicated DFIs in hospitalized patients and their antibiotic sensitivity profiles. Methods. A cross-sectional study was conducted for a period of 24 months from 2012 to 2014 in Nemazee Hospital, Shiraz, Iran. The demographic and clinical features of the patients were obtained. Antimicrobial susceptibility testing to different agents was carried out using the disc diffusion method. Results. During this period, 122 aerobic microorganisms were isolated from DFIs. Among Gram-positive and Gram-negative bacteria, Staphylococcus spp. and E. coli were the most frequent organisms isolated, respectively. Of the isolates, 91% were multidrug while 78% of S. aureus isolates were methicillin resistant. 53% of Gram-negative bacteria were positive for extended-spectrum β-lactamase. Conclusion. Given the involvement of different microorganisms and emergence of multidrug resistant strains, clinicians are advised to consider culture before initiation of empirical therapy.

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“…In another, retrospective, study, 65% of cases resulted in amputation, and the most common bacteria were Staphyloccus spp. (34).…”

Section: Discussionmentioning

confidence: 99%

An evaluation of risk factors affecting amputation in patients with diabetic foot Infection

Alay¹,

Yılmaz²,

Can³

et al. 2021

Journal of Health Sciences and Medicine

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Introduction: Diabetic foot infections are one of the most common complications of diabetes and generally result in lower extremity amputations. Aim: The purpose of this study is to investigate risk factors affecting amputation in patients diagnosed with diabetic foot ulcer. Material and Method: This prospective cohort study involved 137 patients diagnosed with diabetic foot infection in a university hospital diabetic foot clinic. Results: The mean age of the participants was 60.5±10.1 years, and 70.8% (n=97) were men. The majority of patients (62.0%) were educated to elementary or middle school level, while 26.3% were illiterate. Mean duration of diabetes was 13.3±6.2 years. Hypertension was present in 48.2% of patients, hypercholesterolemia in 31.4%, cardiovascular disease (CVD) in 38%, peripheral artery disease (PAD) in 21.2%, peripheral venous insufficiency in 10.2%, and polyneuropathy in 70.1%, and 9.5% were receiving hemodialysis. According to the PEDIS classification, moderate foot ulcers were present in 60.6% of patients, mild ulcers in 34.3%, and severe ulcers in 5.1%. Forty-six percent of patients were diagnosed with osteomyelitis during follow-up. Amputation was present in 28.5% (n=39) of the patients followed-up due to foot ulcers. PAD increased the risk of amputation 2.7-fold (95% CI: 1.02-7.14), osteomyelitis 2.6-fold (95% CI: 1.10-6.16), and repeated hospitalizations 5.9-fold (95% CI: 2.25-15.33). Growth was observed in 72.6% of patients without amputation, 76.5% were polymicrobial, and 65.9% of antibiogram results were multidrug resistant. No significant difference was observed among the patients in terms of multidrug resistance (p=0.468). Conclusion: PAD, osteomyelitis, and history of repeated hospitalizations are separate risk factors for amputation in patients with diabetic foot ulcers.

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Microbiological species and antimicrobial resistance profile in patients with diabetic foot infections

Cited by 12 publications

References 13 publications

Fatores de risco para mortalidade em pacientes submetidos a amputações maiores por pé diabético infectado

Fatores de risco para mortalidade em pacientes submetidos a amputações maiores por pé diabético infectado

Isolation and Antibiotic Susceptibility of the Microorganisms Isolated from Diabetic Foot Infections in Nemazee Hospital, Southern Iran

An evaluation of risk factors affecting amputation in patients with diabetic foot Infection

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