Microbiological Interaction and Diffusion Properties of Hydrophilic and Hydrophobic PU Membranes

Pulat, Mehlíka; Akdoğan, Ayten; Özkan, Semiha Aydın

doi:10.1106/088532802024247

Cited by 9 publications

(4 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Permeation experiments were carried out at 37 ± 1°C36, 37, 39–45 by using a Franz diffusion cell (Fig. 1).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Release of diclofenac through gluteraldehyde crosslinked poly(vinyl alcohol)/poly(acrylic acid) alloy membranes

Şanlı¹,

Asman²

2003

J of Applied Polymer Sci

View full text Add to dashboard Cite

A controlled-release preparation of diclofenac sodium for transdermal administration has been developed. Poly(vinyl alcohol) (PVA) and PVA/poly(acrylic acid) (PAA) alloy membranes were prepared from a solvent-casting technique using different PVA/PAA (v/v) ratios. The release of the drug from the membrane was evaluated under in vitro conditions at pH 7.4. The delivery system provided linear release without time lag, burst effect, and boundary layer resistance. Effects of variables such as film thickness and PVA/PAA ratio on the permeation behavior of the polymeric membranes were discussed. The optimal PVA/ PAA was determined as 50/50.

show abstract

“…Permeation experiments were carried out at 37 ± 1°C36, 37, 39–45 by using a Franz diffusion cell (Fig. 1).…”

Section: Methodsmentioning

confidence: 99%

“…The transdermal patch delivery system may be an attractive choice of an alternative route of administration of this drug. There are many controlled delivery studies for diclofenac 28–38. Rodriguez et al38 studied the release of sodium diclofenac by using an alginate/chitosan system at different pH values.…”

Section: Introductionmentioning

confidence: 99%

Release of diclofenac through gluteraldehyde crosslinked poly(vinyl alcohol)/poly(acrylic acid) alloy membranes

Şanlı¹,

Asman²

2003

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…Swelling percentages (S%) of the unmodified and modified beads were determined gravimetrically by swelling them to a constant weight (W) in PBS at 37 C. The beads were dried at 40 C for 48 h and weighed (W 0 ). S% values were calculated using the following equation [18,19]:…”

Section: Swelling Measurementsmentioning

confidence: 99%

Adsorption of Bovine Serum Albumin onto Surface-Modified Polyhydroxyethyl Methacrylate Beads

Pulat

Memiş²,

Gümüşderelı́oğlu

2003

J Biomater Appl

Self Cite

View full text Add to dashboard Cite

The adsorption of bovine serum albumin (BSA) onto poly(2-hydroxyethyl methacrylate) (PHEMA) beads modified by using the pair of hexamethylene diisocyonate-suberic acidbis-N-hydroxy succinimide has been studied as a function of protein concentration and adsorption time. The adsorption studies were carried out in phosphate buffer solution (PBS) at pH = 7.4. The isotherm data have been analysed using the Langmuir model and the adsorption parameters Q0 and b were calculated. It is determined that the adsorbed amount of BSA increases by the increase of the adsorption time and BSA concentration until a certain value. PHEMA beads were characterized by using FTIR spectra and SEM analysis. The adsorption of BSA onto PHEMA beads were clearly observed from SEM micrographs. The swelling tests of the beads were performed at 37 degrees C in PBS.

show abstract

“…However, new antibacterial strategies are needed in the situation where more and more bacteria are antibiotic-resistant. , Surface treatments have been developed to reduce bacterial adhesion by modifying the physicochemical properties of the substrate in order to reduce the interactions between bacteria and the substrate. These “passive” coatings are based on polyethylene glycol (PEG) − or hydrophilic polyurethane , surface modification and render the surface hydrophilic, allowing a limited bacterial adhesion and proliferation. A recent alternative approach was proposed based on “active” coatings by integrating antibacterial agents at the implant site.…”

Section: Introductionmentioning

confidence: 99%

Embedded Silver Ions-Containing Liposomes in Polyelectrolyte Multilayers: Cargos Films for Antibacterial Agents

et al. 2008

View full text Add to dashboard Cite

A new antibacterial coating made of poly(L-lysine)/hyaluronic acid (PLL/HA) multilayer films and liposome aggregates loaded with silver ions was designed. Liposomes filled with an AgNO 3 solution were first aggregated by the addition of PLL in solution. The obtained micrometer-sized aggregates were then deposited on a PLL/HA multilayer film, playing the role of a spacer with the support. Finally, HA/PLL/HA capping layers were deposited on top of the architecture to form a composite AgNO 3 coating. Release of encapsulated AgNO 3 from this composite coating was followed and triggered upon temperature increase over the transition temperature of vesicles, found to be equal to 34 degrees C. After determination of the minimal inhibitory concentration (MIC) of AgNO 3 in solution, the antibacterial activity of the AgNO 3 coating was investigated against Escherichia coli. A 4-log reduction in the number of viable E. coli cells was observed after contact for 120 min with a 120 ng/cm (2) AgNO 3 coating. In comparison, no bactericidal activity was found for PLL/HA films previously dipped in an AgNO 3 solution and for PLL/HA films with liposome aggregates containing no AgNO 3 solution. The strong bactericidal effect could be linked to the diffusion of silver ions out of the AgNO 3 coating, leading to an important bactericidal concentration close to the membrane of the bacteria. A simple method to prepare antibacterial coatings loaded with a high and controlled amount of AgNO 3 is therefore proposed. This procedure is far superior to that soaking AgNO 3 or Ag nanoparticles into a coating. In principle, other small bactericidal chemicals like antibiotics could be encapsulated by this method. This study opens a new route to modify surfaces with small solutes that are not permeating phospholipid membranes below the phase transition temperature.

show abstract

Microbiological Interaction and Diffusion Properties of Hydrophilic and Hydrophobic PU Membranes

Cited by 9 publications

References 26 publications

Release of diclofenac through gluteraldehyde crosslinked poly(vinyl alcohol)/poly(acrylic acid) alloy membranes

Release of diclofenac through gluteraldehyde crosslinked poly(vinyl alcohol)/poly(acrylic acid) alloy membranes

Adsorption of Bovine Serum Albumin onto Surface-Modified Polyhydroxyethyl Methacrylate Beads

Embedded Silver Ions-Containing Liposomes in Polyelectrolyte Multilayers: Cargos Films for Antibacterial Agents

Contact Info

Product

Resources

About