Release of diclofenac through gluteraldehyde crosslinked poly(vinyl alcohol)/poly(acrylic acid) alloy membranes

Şanlı, Oya; Asman, Gülsen

doi:10.1002/app.13102

Cited by 22 publications

(4 citation statements)

References 45 publications

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“…The addition of PAA to PVA led to a notable increase in the amount of drug being loaded and released, which should be related to the presence of hydrophilic carboxylic side groups (–COOH), which was responsible for the extensive swelling and greater porosity. A similar tendency was observed by Sanli et al [ 62 ] in PVA membranes after PAA incorporation. In a study with hydrogels containing acrylic acid, Jalil et al [ 63 ] performed XRD analysis and found no apparent interaction between DFN and the hydrogels.…”

Section: Discussionsupporting

confidence: 89%

PVA-Based Hydrogels Loaded with Diclofenac for Cartilage Replacement

Branco

Oliveira

Monteiro

et al. 2022

Gels

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Polyvinyl alcohol (PVA) hydrogels have been widely studied for cartilage replacement due to their biocompatibility, chemical stability, and ability to be modified such that they approximate natural tissue behavior. Additionally, they may also be used with advantages as local drug delivery systems. However, their properties are not yet the most adequate for such applications. This work aimed to develop new PVA-based hydrogels for this purpose, displaying improved tribomechanical properties with the ability to control the release of diclofenac (DFN). Four types of PVA-based hydrogels were prepared via freeze-thawing: PVA, PVA/PAA (by polyacrylic acid (PAA) addition), PVA/PAA+PEG (by polyethylene glycol (PEG) immersion), and PVA/PAA+PEG+A (by annealing). Their morphology, water uptake, mechanical and rheological properties, wettability, friction coefficient, and drug release behavior were accessed. The irritability of the best-performing material was investigated. The results showed that the PAA addition increased the swelling and drug release amount. PEG immersion led to a more compact structure and significantly improved the material’s tribomechanical performance. The annealing treatment led to the material with the most suitable properties: besides presenting a low friction coefficient, it further enhanced the mechanical properties and ensured a controlled DFN release for at least 3 days. Moreover, it did not reveal irritability potential for biological tissues.

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Section: Discussionsupporting

confidence: 89%

PVA-Based Hydrogels Loaded with Diclofenac for Cartilage Replacement

Branco

Oliveira

Monteiro

et al. 2022

Gels

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“…However, PVA is a highly hydrophilic polymer and has poor stability in water; thus, its solubility must be prevented for use in aqueous systems. To overcome this problem, PVA should be insolubilized by blending [18], copolymerization [19], grafting [20,21], and cross-linking [22,23]. Recently our laboratory developed modified IPN-based carbohydrate polymers for CR systems of various types of drugs [24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of pH sensitive poly(vinyl alcohol)/sodium carboxymethyl cellulose IPN microspheres for in vitro release studies of an anti-cancer drug

et al. 2011

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Interpenetrating polymeric network microspheres (IPNMs) consisting of poly(vinyl alcohol) and sodium carboxymethylcellulose were prepared by water-inoil emulsion method and were cross-linked with glutaraldehyde. 5-Fluorouracil (5-FU), an anti-cancer drug, was loaded into IPNMs via in situ method. These IPNMs have been characterized by Fourier transform infrared spectroscopy, which confirms the cross-linking of IPNMs through glutaraldehyde. Differential scanning calorimetry and X-ray diffraction analysis of the drug-loaded IPNMs have confirmed uniform molecular dispersion of 5-FU in the IPNMs. Particle size measured using optical microscopy gave an average size of 80-250 lm. Scanning electron microscopy also confirmed the formation of microspheres with smooth surface and spherical shape. Encapsulation efficiency of 5-FU in these IPNMs was achieved up to 62%. Drug release profiles of the IPNMs at different pH conditions (pH 1.2 and 7.4) confirmed that microspheres formed are pH sensitive, resulting controlled release of drug during in vitro dissolution experiments. It has been analyzed with an empirical equation to understand the diffusion nature of drug through the IPNMs. Both encapsulation efficiency and release patterns are found to depend on the nature of the cross-linking agent as well as amount of drug loading. In vitro release studies indicated the release of 5-FU for more than 10 h.

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“…Permeation studies were carried out in a thermostated water bath, by using a Franz diffusion cell, 38 which consists of a donor compartment and an acceptor compartment separated by the membrane. The donor compartment holds theophylline solution (5 mg/mL) and acceptor compartment was filled with buffer solution at a pH of 7.4. pH adjustments of the solutions were done using a Hanna pH211 model pH meter.…”

Section: Permeation Studiesmentioning

confidence: 99%

Effect of sonic treatment on the permeation performance of cellulose acetate membranes modified by n-SiO$_{2}$

Asman¹,

Kaya²,

Bayramgil³

2015

Turk J Chem

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Cellulose acetate (CA) membranes were modified by nano-silicon dioxide (n-SiO 2) , and they were exposed to ultrasonic waves at a frequency of 35 kHz. The effect of sonication on their water sorption tendency and permeation capability was investigated. The characterization of the membranes was done by FTIR and SEM analysis, and the hydrophilic character of the membranes was deduced by swelling studies and contact angle (CAn) measurements.Permeation studies of the membranes were performed by using the diffusion method and theophylline was used as a model chemical in the permeation studies. The results indicated that beside the high hygroscopic property of n-SiO 2 , the presence of n-SiO 2 in CA membranes did not significantly improve their hydrophilicity; however, when they were exposed to sonic waves, it was determined that the sonication effectively enhanced their water sorption capacity and permeability.

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Release of diclofenac through gluteraldehyde crosslinked poly(vinyl alcohol)/poly(acrylic acid) alloy membranes

Cited by 22 publications

References 45 publications

PVA-Based Hydrogels Loaded with Diclofenac for Cartilage Replacement

PVA-Based Hydrogels Loaded with Diclofenac for Cartilage Replacement

Preparation and characterization of pH sensitive poly(vinyl alcohol)/sodium carboxymethyl cellulose IPN microspheres for in vitro release studies of an anti-cancer drug

Effect of sonic treatment on the permeation performance of cellulose acetate membranes modified by n-SiO$_{2}$

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