Microbiological Evaluation of the Pathogens Isolated From the Endotracheal Aspirate Samples of the Patients Followed in the Intensive Care Units: A One-Year Retrospective Analysis

Sağmak-Tartar, Ayşe; Özer, Ayşe Belin; Ulu, Ramazan; Akbulut, Ayhan

doi:10.5152/kd.2018.14

Cited by 12 publications

(12 citation statements)

References 5 publications

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“…3,5 In the study conducted by Sağmak Tartar et al carbapenem resistance was found 97.7% for Acinetobacter isolates. 16 Similar to our data, Altay Koçak et al found that carbapenem, fluoroquinolone, ceftazidime and piperacillin/tazobactam resistance rates of A. baumannii isolates were above 90% and resistance rates were higher in ICUs than in wards. 17 They determined that colistin resistance, which is becoming a worldwide problem, was lower than the national average (2%).…”

Section: Discussionsupporting

confidence: 91%

Evaluation of Pathogens and Antibiotic Resistance Profiles Isolated from Lower Respiratory Tract Samples

Gurbuz

ÇİMKE

ALTUNKARA

et al. 2023

Kocaeli Üniversitesi Sağlık Bilimleri Dergisi

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Objective: In this study, we aimed to guide clinicians in planning empirical treatment and contribute to regional data by presenting bacterial lower respiratory tract infection agents and antibiotic resistance profiles. Methods: All lower respiratory tract samples from patients admitted to our laboratory between January 01 and December 31, 2021 were evaluated retrospectively. Bacterial identification and susceptibility tests were performed using the VITEK 2 automated system and evaluated in accordance with the recommendations of the European Committee on Antimicrobial Susceptibility Testing (EUCAST). Results: Significant growth was detected in 461 of 923 lower respiratory tract samples. Antibiotic susceptibility test results of 340 samples were evaluated after excluding the repeated samples of same patient. Gram negative bacteria was isolated in 309 (90.9%), Staphylococcus aureus in 17 (5%) and Candida albicans in 14 (4.1%) of 340 samples. The most frequently isolated Gram-negative bacteria were Pseudomonas aeruginosa (121, 39.2%), Acinetobacter baumannii (88, 28.5%), Klebsiella pneumoniae (64, 20.7%) and Escherichia coli (36, 11.6%), respectively. Resistance rates of A. baumannii isolates to carbapenems, piperacillin/tazobactam, ceftazidime and fluoroquinolones were found to be over 90%, and higher resistance was observed in intensive care units (ICU) than in wards. Conclusion: The increased antibiotic resistance observed in lower respiratory tract infections from hospitalized patients in ICUs, is remarkable. As a result, knowing the causative agents and current resistance profiles is important, especially for hospitalized patients in ICUs, in order to initiate appropriate empirical treatment and to ensure treatment success. The data obtained from our study will guide clinicians in planning empirical treatment.

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Section: Discussionsupporting

confidence: 91%

Evaluation of Pathogens and Antibiotic Resistance Profiles Isolated from Lower Respiratory Tract Samples

Gurbuz

ÇİMKE

ALTUNKARA

et al. 2023

Kocaeli Üniversitesi Sağlık Bilimleri Dergisi

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“…Increased resistance to carbapenems has been found to be higher in ICUs [16]. Tartar et al found 70.9% resistance rate in 127 of P.auroginosa strains [10]. In our study, the resistance rate of P.aeruginosa to meropenem and imipenem were 48,2% and 51,7%, respectively.…”

Section: Discussionsupporting

confidence: 47%

“…The most common causes of nosocomial infections are LR-TIs which has a high morbidity and mortality rates. The major causes of NLRTIs are gram-negative nonfermentative microorganisms such as Acinetobacter and Pseudomonas [10]. In our study, gram-negative bacteria were isolated in 90 (79.6%) samples.…”

Section: Discussionmentioning

confidence: 60%

“…S.aureus was found in 13 (11.5%) cases in the third frequency. In the study by Tartar et al, 620 growth were identified from ETA samples and isolated bacterias were as follows: 307 (%49,5) A. baumanii, 127 (%20,5) P. Auroginosa, 101 (%16,3) K. pneumoniae 13 (%2,1) S. aureus, respectively [10]. In the study by Aydemir et al, 141 bacterias were determined in 130 ETA samples.…”

Section: Discussionmentioning

confidence: 99%

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Antibiotic resistance profiles of endotracheal aspirates in intensive care unit patients

Koca¹

2019

Ann Clin Anal Med

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Aim: In the patients hospitalized in intensive care units (ICU) infectious agents of the lower respiratory tract are nosocomial pathogens that causes severe morbidity and mortality. The aim of our study is to determine the bacterial growth and antibiotic resistance profiles of bacterias isolated from endotracheal aspirate cultures (ETA) obtained from ICU's of our hospital for the last one year. Material and Method: Between October 2017 and September 2018, ETA samples from adult intensive care units were examined retrospectively. In addition to conventional methods, identification and antibiotic susceptibilities were studied in accordance with the recommendations of the European Committee on Antimicrobial Susceptibility Testing (EUCAST) using fully automated VITEC (Biomerieux, France). Results: Of the 205 ETA specimens from adult ICU's, 113 growths were detected in 103 patients. In ETA, 37 (32,7%) Acinetobacter baumannii, 29 (25,6%) Pseudomonas aeruginosa, 13 (11.5%) Staphylococcus aureus, 12 (%10,6) Klebsiella pneumoniae, 6 (5,3%) Escherichia coli, 4 (3,5%) Enterobacter cloacae and 2 (1,7%) Stenotrophomonas malthophiliae was isolated. Meropenem and imipenem resistance of A. baumannii was 89.1% for both, whereas it was 48,2% and 51,7% for P. auroginosa, respectively. Colistin and tigesiklin resistance was not detected for all isolates. Oxacillin resistant S.aureus strains were determined as 46.1% (6/13), while linezolid, teicoplanin, and vancomycin resistance were not detected. Discussion: Increased carbapenem resistance observed in antimicrobial susceptibility tests, for the most frequently bacterias isolated from ETA samples in ICU of our hospital, has shown the importance of the antimicrobial susceptibility testing.

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“…(17) %33.3; ETA örneklerinde Tartar ve ark. (18) %100; balgam örneklerinde Orak (19) %100, solunum yolu örneklerinde (ETA ve balgam) Koçak ve ark. (20) %28.6 olarak belirlemişlerdir.…”

Section: Discussionunclassified

Çeşitli Klinik Örneklerden İzole Edilen Staphylococcus aureus Suşlarının Antibiyotik Direnç Oranları

Duran¹,

Çeken²,

Ati̇k³

2021

TMCD

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Objective: Staphylococcus aureus is an important pathogen that can cause both community and hospital-acquired infections. The presence of methicillin resistant isolates limits treatment options. The aim of this study was to determine the antibiotic resistance rates in S. aureus strains isolated from outpatients and inpatients in our hospital. Method: Various clinical specimens were evaluated retrospectively between 2016-2019 and S. aureus strains were included in the study. Bacterial identification and antibiotic susceptibility tests were performed using conventional methods and automated systems. Results: In our study, 595 S. aureus strains were assessed. The strains included in the study were most frequently isolated from blood and wound samples. One hundred and seventy-two isolates (28.9%) were identified as methicillin resistant S. aureus (MRSA). The resistance rates to erythromycin, tetracycline, clindamycin, gentamicin, ciprofloxacin and trimethoprim-sulfamethoxazole were 16.8% or below. High resistance rates were observed in MRSA against these antimicrobials compared to methicillin-susceptible S. aureus (MSSA) strains. Resistance was not found against vancomycin, teicoplanin and linezolid, whereas resistance to daptomycin was 0.7%. Conclusion: Antibiotic resistance is one of the most important health problems of today.Resistance to both methicillin and other antibiotics decreases the success rates of treatment in S. aureus infections. Therefore, it is very important to regularly monitor antibiotic resistance surveillance.

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Microbiological Evaluation of the Pathogens Isolated From the Endotracheal Aspirate Samples of the Patients Followed in the Intensive Care Units: A One-Year Retrospective Analysis

Cited by 12 publications

References 5 publications

Evaluation of Pathogens and Antibiotic Resistance Profiles Isolated from Lower Respiratory Tract Samples

Evaluation of Pathogens and Antibiotic Resistance Profiles Isolated from Lower Respiratory Tract Samples

Antibiotic resistance profiles of endotracheal aspirates in intensive care unit patients

Çeşitli Klinik Örneklerden İzole Edilen Staphylococcus aureus Suşlarının Antibiyotik Direnç Oranları

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