Microbiological Aspects and Inflammatory Response of Pulp Tissue in Traumatic Dental Lesions

Tripodi, Domenico; Latrofa, M.; D’Ercole, Simonetta

doi:10.1177/1721727x0700500301

Cited by 4 publications

(5 citation statements)

References 35 publications

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“…Since lack of published reference values prevents from discriminating which outliers represent errors or an actual enhanced response in some individuals, outliers were not discarded opting for a non-parametric test, which is least influenced by outliers, for data analysis. Lastly, since our study focused on CRP changes, the overall status of the inflammation response following ACL surgery has not been exhaustively described (17)(18)(22)(23).…”

Section: Discussionmentioning

confidence: 99%

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Clinical and Laboratory Changes in the Uncomplicated Course of Arthroscopic Anterior Cruciate Ligament (ACL) Reconstruction: A Prospective Observational Study in 58 Patients

Calvisi¹,

Lupparelli²,

Rossetti³

et al. 2008

Eur J Inflamm

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Knowledge of post-operative clinical and laboratory changes in the uncomplicated course of ACL reconstruction could assist orthopaedic surgeons in making a timely diagnosis of septic arthritis. A total of 58 candidates to ACL reconstruction were enrolled in this study according to inclusion/exclusion criteria. Pre-and post-operative changes on I", 3 rd , T", 15 th, and 30 t h day were collected for skin body temperature (SBT), knee pain (KP), white blood cell (WBC) count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP). Post-operative joint effusion was recorded when inhibiting quadriceps contraction. The post-operative changes were compared with baseline values at each time point in the whole sample and in the subgroups of patients receiving bone-patellar-tendon-bone (BPTP) or hamstring tendon (HT) autograft. Follow-up at six month was considered adequate to rule out surgery-related septic arthritis. Mean SBT significantly increased on I", 3 r d and 7 th post-operative day and returned to values not differing from baseline on 15 t h and 30 t h day. Median KP was significantly elevated during the first month. Joint effusion was observed on 7 t h post-operative day in 52% of patients. Mean WBC count significantly increased on 1'1, T" and 15 t h day while no difference from baseline was observed on 3 rd and 30 th day. Mean ESR was significantly elevated on I" day, increased on 3 rd day and peaked on 7 th day. ESR decreased on 15 t h and 30 th day but remained significantly higher than baseline. Mean CRP significantly increased on 1st day, peaked on 3 rd day and decreased on 7 t h day, while levels on 15 th and 30 th day did not differ from baseline. The SBT, KP, WBC count, ESR and CRP changes stratified in relation to the type of autograft showed the same variation trend as in the whole sample. Close clinical surveillance may be advisable when SBT, occurrence of joint effusion and CRP levels deviate from the described reference trend two weeks after surgery.Although the natural history of ACL-insufficient knees is unclear (1-2), it is generally agreed that recurrent episodes of symptomatic instability would lead to an accrual ofjoint damage (l , 3), particularly if a meniscectomy has been performed following ACLtear (4). The indication for ACL reconstruction includes the desire of recreational or professional athletes to return promptly to the pre-injury activity level or the persistence of symptomatic instability following rehabilitation and activity level modifications (l, 3).The onset of septic arthritis, the reported rate of

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Section: Discussionmentioning

confidence: 99%

“…ESR is elevated when a local or systemic inflammation is present regardless of its cause. CRP is an acute-phase plasma protein increasing in bacterial infection and extensive tissue damage (17)(18). It is analysed in venous blood collected in a serum-separating tube according to various methods.…”

Section: Methodsmentioning

confidence: 99%

Clinical and Laboratory Changes in the Uncomplicated Course of Arthroscopic Anterior Cruciate Ligament (ACL) Reconstruction: A Prospective Observational Study in 58 Patients

Calvisi¹,

Lupparelli²,

Rossetti³

et al. 2008

Eur J Inflamm

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“…In most cases, analgesic medication is not effective. Microscopically acute inflammation is accompanied by increased vascular permeability, exudation of fluid, serum proteins, inflammatory mediators, and cells, especially polymorphonuclear leukocytes (PMN), into the affected area [13,14]. If the injurious agent is removed, healing of the dental pulp tissue can be achieved.…”

Section: Introductionmentioning

confidence: 99%

“…Most cases of irreversible chronic pulpitis can be painless or a dull located pain may be present [10]. With chronic dental pulp inflammation, accumulation of a granuloma-like tissue and irreversible destruction of the parenchymal tissue, which is covered by a connective and fibrous tissue, takes place [13]. Fibroblasts and vascular endothelium proliferation, as well as an invasion of lymphocytes, plasma cells, macrophages, and inflammatory mediators occur [14].…”

Section: Introductionmentioning

confidence: 99%

“…Fibroblasts and vascular endothelium proliferation, as well as an invasion of lymphocytes, plasma cells, macrophages, and inflammatory mediators occur [14]. Additionally, in irreversible chronic pulpitis, an activation of cell-mediated bacterial lysate, cytokine system, can be observed, together with T and B cell stimulation [13]. Chronic inflammation of the dental pulp may be preceded by an acute inflammatory process or it can be primary [14].…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Mineralization, Oxidative Stress, and Inflammation Mechanisms in the Pulp of Primary Teeth

et al. 2022

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Inflammation in primary teeth (PT) is commonly associated with a lower sensibility to painful stimuli, compared to permanent teeth, and usually leads to late presentation for dental treatment. Data obtained on the molecular assessments of dental pulp and clinical examinations could guide practitioners to conduct precise diagnoses and correct treatments. The aim of our pilot study was to assess the levels of several biomarkers (e.g., mineralization, oxidative stress, and inflammation) in primary teeth. The research included 46 dental pulp specimens collected from the primary teeth of children and adolescents between the ages of 6 and 12. The experimental groups consisted of 18 samples collected from primary teeth with acute pulpitis and 15 samples from chronically inflamed pulp tissues. The control group was represented by 13 specimens acquired from clinically healthy primary teeth. The enzyme-linked immunosorbent assay (ELISA) technique was used to determine the protein expression of tumor necrosis factor-α (TNF-α), superoxide dismutase-3 (SOD-3), osteocalcin, and transforming growth factor-β1 (TGF-β1) in the lysates. Our results revealed that all of the studied parameters presented statistically significant (p ≤ 0.05) increased levels in both experimental groups compared to the control samples. Furthermore, osteocalcin presented statistically significant increased concentrations in chronically- versus acute-inflamed pulp samples (p ≤ 0.05). The studied molecules may have an influential role in acute and chronic pulp inflammation in primary teeth.

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Micronutrients and bioactive compounds in oral inflammatory diseases

Kaur

Sculley²,

Wallace

et al. 2019

Journal of Nutrition & Intermediary Metabolism

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Microbiological Aspects and Inflammatory Response of Pulp Tissue in Traumatic Dental Lesions

Cited by 4 publications

References 35 publications

Clinical and Laboratory Changes in the Uncomplicated Course of Arthroscopic Anterior Cruciate Ligament (ACL) Reconstruction: A Prospective Observational Study in 58 Patients

Clinical and Laboratory Changes in the Uncomplicated Course of Arthroscopic Anterior Cruciate Ligament (ACL) Reconstruction: A Prospective Observational Study in 58 Patients

Assessment of Mineralization, Oxidative Stress, and Inflammation Mechanisms in the Pulp of Primary Teeth

Micronutrients and bioactive compounds in oral inflammatory diseases

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