Micronutrients and bioactive compounds in oral inflammatory diseases

Kaur, Kiranjit; Sculley, Dean V.; Wallace, Janet; Turner, Alexandria; Ferraris, Celeste; Veysey, Martin; Lucock, Mark; Beckett, Emma L.

doi:10.1016/j.jnim.2019.100105

Cited by 15 publications

(4 citation statements)

References 150 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has also been reported that low serum selenium levels may be associated with the severity of periodontal disease [ 47 ]. Although studies are limited, maintaining selenium levels in periodontal disease may help manage them [ 48 ]. Nevertheless, the mean daily selenium intake was higher in the case group in the present study.…”

Section: Discussionmentioning

confidence: 99%

A pro-inflammatory diet is associated with an increased odds of periodontitis: finding from a case–control study

Ghaemmaghami,

Bayani,

Nakhostin

et al. 2023

BMC Nutr

View full text Add to dashboard Cite

Objective This study aimed to evaluate the inflammatory effect of diet using the dietary Inflammatory Index (DII) on the odds of periodontitis. We hypothesized that a diet with high DII scores (a pro-inflammatory diet) is associated with high chronic and systematic inflammation resulting in periodontitis. Periodontitis is one of the most common inflammatory diseases that affect the tissues around the tooth and results from the interaction of bacterial infection and the host immune response. The DII shows the association between different food components and the level of specific inflammatory biomarkers. Method The food intake of 87 cases with diagnosed periodontitis and 87 control was assessed using a 163-item valid food frequency questionnaire (FFQ). The DII was calculated based on the FFQ data. Logistic and linear regression models adjusting for multivariable confounders were used to investigate the odds ratio (OR) and 95% confidence intervals (CI) of developing periodontitis. Results There was a significant difference between the mean intake of micronutrients and food groups, including saturated fatty acids (SFAs), iron, magnesium, manganese, vitamin C, crude fiber, selenium, chromium, whole fiber, caffeine, dairy, and meat, between patients with periodontitis and the control group (p-value˂0.05). DII scores in this study ranged from -3.13 to + 0.99. However, the periodontitis OR in the raw and multivariable-adjusted models was not statistically significant (multivariable-adjusted OR tertiles 1 vs. tertiles 3 = 2.00, 95%CI: 0.4–90.42, p-value = 0.08). A similar result was also observed in the continuous model of DII (multivariable-adjusted OR DII continuous = 1.93, 95%CI: 0.30–98.79, p-value = 0.05). Conclusion Although the OR was not statistically significant in crude models, a significant trend was found in multivariable-adjusted models. The results were promising since this is the first study to examine the association between diet-induced inflammation and dental disease. It is advisable to conduct additional studies with high sample sizes and other designs, such as prospective studies.

show abstract

Section: Discussionmentioning

confidence: 99%

A pro-inflammatory diet is associated with an increased odds of periodontitis: finding from a case–control study

Ghaemmaghami,

Bayani,

Nakhostin

et al. 2023

BMC Nutr

View full text Add to dashboard Cite

show abstract

“…Vitamin D deficiency can also inhibit periodontal tissue healing [ 187 ]. Furthermore, the deficiency of this micronutrient, due to an unbalanced diet, can contribute to oral dysbiosis [ 188 ]. Therefore, considering the importance of vitamin D in oral health, many studies have been performed to evaluate vitamin D supplementation efficacy and safety during or after periodontitis therapy.…”

Section: Alterations Of Vitamins Levels In Ckd Patients and Their Inf...mentioning

confidence: 99%

The Impact of Chronic Kidney Disease on Nutritional Status and Its Possible Relation with Oral Diseases

et al. 2022

View full text Add to dashboard Cite

Several studies have demonstrated a strong relation between periodontal diseases and chronic kidney disease (CKD). The main mechanisms at the base of this link are malnutrition, vitamin dysregulation, especially of B-group vitamins and of C and D vitamins, oxidative stress, metabolic acidosis and low-grade inflammation. In particular, in hemodialysis (HD) adult patients, an impairment of nutritional status has been observed, induced not only by the HD procedures themselves, but also due to numerous CKD-related comorbidities. The alteration of nutritional assessment induces systemic manifestations that have repercussions on oral health, like oral microbiota dysbiosis, slow healing of wounds related to hypovitaminosis C, and an alteration of the supporting bone structures of the oral cavity related to metabolic acidosis and vitamin D deficiency. Low-grade inflammation has been observed to characterize periodontal diseases locally and, in a systemic manner, CKD contributes to the amplification of the pathological process, bidirectionally. Therefore, CKD and oral disease patients should be managed by a multidisciplinary professional team that can evaluate the possible co-presence of these two pathological conditions, that negatively influence each other, and set up therapeutic strategies to treat them. Once these patients have been identified, they should be included in a follow-up program, characterized by periodic checks in order to manage these pathological conditions.

show abstract

“…As for the aetiology of the oral diseases, various aspects are involved. The risk factors include unhealthy lifestyles, psychological distress, oral microbiome and even genetics 16 , 17 . Among them, dietary habits are intimately associated with oral diseases 2 , 18 .…”

Section: Introductionmentioning

confidence: 99%

Assessing the association between tea intake and risk of dental caries and periodontitis: a two-sample Mendelian randomization study

Jin,

Chen,

Liu

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Tea is an indispensable beverage in people’s daily life. However, the relationship between tea intake and dental caries and periodontitis is controversial. We extracted datasets for tea intake and oral diseases from genome-wide association studies (GWASs) conducted by the UK Biobank and the Gene Lifestyle Interactions in Dental Endpoints consortium. We selected 38 single-nucleotide polymorphisms (SNPs) significantly associated with tea intake as instrumental variables (IVs) (P < 5.0 × 10–8). Mendelian randomization (MR) was performed to investigate the potential causality between tea intake and caries and periodontitis. Multivariable Mendelian randomization (MVMR) analyses were utilized to estimate causal effects of tea intake on risk of caries and periodontitis after adjusting for smoking, body mass index (BMI), and socioeconomic factors. The results showed that higher tea intake was suggestively associated with fewer natural teeth (β = − 0.203; 95% CI = 0.680 to 0.980; P = 0.029) and higher risk of periodontitis (OR = 1.622; 95% CI = 1.194 to 2.205; P = 0.002). After Bonferroni correction, the causality of tea intake on periodontitis remained significant. The significance of periodontitis disappeared after adjusting for the socioeconomic factors in MVMR (OR = 1.603; 95% CI = 0.964 to 2.666; P = 0.069). Tea intake had no association with risk of caries. Statistical insignificance of the heterogeneity test and pleiotropy test supported the validity of the MR study. Our results provide insight into the potential relationship between tea intake and oral diseases from a dietary lifestyle perspective, which may help prevent oral diseases.

show abstract

Micronutrients and bioactive compounds in oral inflammatory diseases

Cited by 15 publications

References 150 publications

A pro-inflammatory diet is associated with an increased odds of periodontitis: finding from a case–control study

A pro-inflammatory diet is associated with an increased odds of periodontitis: finding from a case–control study

The Impact of Chronic Kidney Disease on Nutritional Status and Its Possible Relation with Oral Diseases

Assessing the association between tea intake and risk of dental caries and periodontitis: a two-sample Mendelian randomization study

Contact Info

Product

Resources

About