Microbial production of short chain diols

Abstract

Short chain diols (propanediols, butanediols, pentanediols) have been widely used in bulk and fine chemical industries as fuels, solvents, polymer monomers and pharmaceutical precursors. The chemical production of short chain diols from fossil resources has been developed and optimized for decades. Consideration of the exhausting fossil resources and the increasing environment issues, the bio-based process to produce short chain diols is attracting interests. Currently, a variety of biotechnologies have been developed for the microbial production of the short chain diols from renewable feed-stocks. In order to efficiently produce bio-diols, the techniques like metabolically engineering the production strains, optimization of the fermentation processes, and integration of a reasonable downstream recovery processes have been thoroughly investigated. In this review, we summarized the recent development in the whole process of bio-diols production including substrate, microorganism, metabolic pathway, fermentation process and downstream process.

Inflammatory bowel disease and patterns of volatile organic compounds in the exhaled breath of children: A case-control study using Ion Molecule Reaction-Mass Spectrometry

“…[ 57 – 59 ] A possible hypothesis to explain this result is the pivotal role of ammonia and other short–chain fatty acids in determining the onset or chronicity of IBD, since the microbiota of IBD patients synthesizes large amounts of these compounds. [ 50 , 57 ]…”

Production of C2–C4 diols from renewable bioresources: new metabolic pathways and metabolic engineering strategies

“…C2–C4 diols represent one of the most important categories of bulk chemicals which are classically produced from fossil resource by chemical processes. Due to the depletion of fossil resource and increasing environmental issues, there is an increasing demand for production of these platform chemicals from renewable resources by more sustainable biological processes [ 2 , 115 ]. Several isomers of C2–C4 diols are non-natural metabolites that lack known metabolic pathways.…”

“…Diols are compounds containing two hydroxyl groups. C2–C4 diols (ethylene glycol, propanediols, and butanediols) are very important platform chemicals which have been widely used in various areas including solvents, fuels, polymers, cosmetics, and pharmaceuticals [ 1 , 2 ]. For example, ethylene glycol (EG), 1,3-propanediol (1,3-PDO), and 1,4-butanediol (1,4-BDO) are among the most important building blocks of polymer industry for the synthesis of polyethylene terephthalate (PET), polypropylene terephthalate (PTT), and polybutylene terephthalate (PBT) [ 3 , 4 ].…”

Chemicals from renewable biomass: A renaissance in carbohydrate chemistry

“…The commercially important diols: 1,3-propanediol (1,3-PDO), 2,3-butanediol (2,3-BDO) and 1,4butanediol (1,4-BDO) can be produced efficiently by fermentation (Figure2) [20]. Indeed, the development by DuPont [21] of cost-effective production of 1,3-PDO, the key raw material for polytrimethylene terephthalate, in recombinant E.coli , was a watershed in modern biotechnology [22].…”