Microbial metabolism of α-mangostin isolated from Garcinia mangostana L.

Arunrattiyakorn, Panarat; Suksamrarn, Sunit; Suwannasai, Nuttika; Kanzaki, Hiroshi

doi:10.1016/j.phytochem.2011.02.007

Cited by 38 publications

(20 citation statements)

References 19 publications

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“…Among the essential phytonutrients found in the rind of the mangosteen, α-mangostin or 1 , 3 , 6 - trihydroxy - 7 - methoxy , 2 - 8 - bis ( 3 - methyl - but - 2 - enyl )- xanthen - 9 - one stands alone in its impressive benefits. Since it was first discovered by W. Schmid in 1855 [3], this compound has attracted many researchers due to its biological active properties such as antioxidant [4], anti bacteria [5], antifungal [6], anti inflammatory [7], anti cancer [8] and anti tuberculosis [9], therapeutic drugs [10] and also being used as mosquitoes larvicide [11]. Furthermore, it has been commercialised as supplement in food products and natural dyes in fabric industries, which are readily available in the worldwide market.…”

Section: Introductionmentioning

confidence: 99%

A study on dispersion and characterisation of α-mangostin loaded pH sensitive microgel systems

Ahmad

Yamin

Lazim

2013

Chemistry Central Journal

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Backgroundα-Mangostin was extracted with methanol from the rind of mangosteen fruit and purified by using silica gel column chromatography technique. The compound is characterised using infrared, 13C and 1H NMR as well as UV–vis spectroscopy. The α-mangostin dispersion in colloidal systems was studied by incorporating it with an ionic microgel, poly (N-Isopropylacrylamide)-co-2VP at different pH.ResultThe DLS result showed the size of microgel-α-mangostin mixture declined from 548 nm to 200 nm upon the increment of the pH. Moreover, it was found the morphology of loaded compound depended largely on the nature of the continuous phase of the microgel system. Interestingly, by manipulating the pH, α-mangostin tends to form crystal at extremely low pH and transforms into spherical shapes at pH 6.ConclusionThis research shows different structures of the α-mangostin particle that are attributed by adjusting the pH using microgel systems as a template.

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Section: Introductionmentioning

confidence: 99%

A study on dispersion and characterisation of α-mangostin loaded pH sensitive microgel systems

Ahmad

Yamin

Lazim

2013

Chemistry Central Journal

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“…The garcinone B, α-, and β-mangostins exhibited the most potent inhibitory effect against Mycobacterium tuberculosis [17]. The α-mangostin has been reported to exhibit antifungal and antiviral activities [18]. Several xanthones from pericarp of mangosteen are used as medicinal agents for the treatment of skin infections, wounds [19], and diarrhea [20].…”

Section: Introductionmentioning

confidence: 99%

Antileptospiral activity of xanthones from Garcinia mangostanaand synergy of gamma-mangostin with penicillin G

Seesom

Jaratrungtawee

Suksamrarn

et al. 2013

BMC Complement Altern Med

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BackgroundLeptospirosis, one of the most widespread zoonotic infectious diseases worldwide, is caused by spirochetes bacteria of the genus Leptospira. The present study examined inhibitory activity of purified xanthones and crude extracts from Garcinia mangostana against both non-pathogenic and pathogenic leptospira. Synergy between γ-mangostin and penicillin G against leptospires was also determined.MethodsMinimal inhibitory concentrations (MIC) of crude extracts and purified xanthones from G. mangostana and penicillin G for a non-pathogenic (L. biflexa serovar Patoc) and pathogenic (L. interrogans serovar Bataviae, Autumnalis, Javanica and Saigon) leptospires were determined by using broth microdilution method and alamar blue. The synergy was evaluated by calculating the fractional inhibitory concentration (FIC) index.ResultsThe results of broth microdilution test demonstrated that the crude extract and purified xanthones from mangosteen possessed antileptospiral activities. The crude extracts were active against all five serovars of test leptospira with MICs ranging from 200 to ≥ 800 μg/ml. Among the crude extracts and purified xanthones, garcinone C was the most active compound against both of pathogenic (MIC =100 μg/ml) and non-pathogenic leptospira (MIC = 200 μg/ml). However, these MIC values were higher than those of traditional antibiotics. Combinations of γ-mangostin with penicillin G generated synergistic effect against L. interrogans serovars Bataviae, Autumnalis and Javanica (FIC = 0.52, 0.50, and 0.04, respectively) and no interaction against L. biflexa serovar Patoc (FIC =0.75). However, antagonistic activity (FIC = 4.03) was observed in L. interrogans serovar Saigon.ConclusionsCrude extracts and purified xanthones from fruit pericarp of G. mangostana with significant antibacterial activity may be used to control leptospirosis. The combination of xanthone with antibiotic enhances the antileptospiral efficacy.

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“…α-mangostin has many pharmacological properties such as mosquitoes larvicide, anti-bacteria, antifungal 8 , anti-cancer 9 , antioxidant 10 , anti-tuberculosis 11 , and analgesic. 12 It also has strong activity as anti-cancer. α-mangostin (10 µM) inhibited of HL60 (Human Promyelocytic) leukemia cell line in humans via apoptotic induction 9 .…”

Section: Introductionmentioning

confidence: 99%

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY FOR Α-Mangostin ANALYSIS IN MANGOSTEEN PERICARP EXTRACT FOR ROUTINE ANALYSIS WITH PHOTODIODE ARRAY DETECTOR

Muchtaridi¹,

Prasetio²,

Saptarini³

et al. 2018

RJC

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The analytical methods for the standardization of α-mangostin are needed to set up a routine of a validated method for quality control of α-mangostin from Garcinia mangostana L. using HPLC methods. This study was aimed to validate the analytical method of High-Performance Liquid Chromatography (HPLC) for α-mangostin analysis with Photodiode Array (PDA). The analysis was conducted by HPLC with octadecyl silanol column, methanol and acetic acid 1% as a mobile phase and PDA detection at 243 nm. The coefficient correlation of analytical method was was 0.9999, the variation was less than 2%, LOD was 0.671 ppm, and LOQ was 2.174 ppm. The level of α-mangostin in mangosteen pericarp extract from Tasikmalaya was 8.56 ± 0.003%. The analytical method was met the validation criteria. The PDA sensitivity was 68.28% higher than UV-Vis detector.

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Microbial metabolism of α-mangostin isolated from Garcinia mangostana L.

Cited by 38 publications

References 19 publications

A study on dispersion and characterisation of α-mangostin loaded pH sensitive microgel systems

A study on dispersion and characterisation of α-mangostin loaded pH sensitive microgel systems

Antileptospiral activity of xanthones from Garcinia mangostanaand synergy of gamma-mangostin with penicillin G

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY FOR Α-Mangostin ANALYSIS IN MANGOSTEEN PERICARP EXTRACT FOR ROUTINE ANALYSIS WITH PHOTODIODE ARRAY DETECTOR

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