A study on dispersion and characterisation of α-mangostin loaded pH sensitive microgel systems

Abstract

Backgroundα-Mangostin was extracted with methanol from the rind of mangosteen fruit and purified by using silica gel column chromatography technique. The compound is characterised using infrared, 13C and 1H NMR as well as UV–vis spectroscopy. The α-mangostin dispersion in colloidal systems was studied by incorporating it with an ionic microgel, poly (N-Isopropylacrylamide)-co-2VP at different pH.ResultThe DLS result showed the size of microgel-α-mangostin mixture declined from 548 nm to 200 nm upon the increment of the pH. Moreover, it was found the morphology of loaded compound depended largely on the nature of the continuous phase of the microgel system. Interestingly, by manipulating the pH, α-mangostin tends to form crystal at extremely low pH and transforms into spherical shapes at pH 6.ConclusionThis research shows different structures of the α-mangostin particle that are attributed by adjusting the pH using microgel systems as a template.

Correlation between Structures and Antioxidant Activities of Polyvinylpyrrolidone/Garcinia mangostana L. Extract Composite Nanofiber Mats Prepared Using Electrospinning

“…One of the FTIR characteristic peaks of the GME was observed at 3273 cm −1 , which was assigned for O-H stretching [5]. This indicated the presence of polyphenol in GME.…”

“…The other peaks appearing at 1638, 1440, 1279, and 1077 cm −1 represented C=O stretching of carbonyl group, aromatic C=C stretching, C-O-C stretching of methoxy group, and C-O-C stretching, respectively [27,28]. C-H stretching from methyl groups was indicated by two peaks at 2853 and 2923 cm −1 [5]. The GME was therefore rich in hydroxyl (O-H), carbonyl (C=O), and methoxy (C-O-C) groups as previously found [28].…”

“…The group of compounds in GME which plays a role in a wide range of bioactivity is -mangostin [5]. To measure the level of -mangostin in GME and nanofiber mats, a quantitative analysis had been conducted using HPLC (Agilent Technology, USA).…”

“…They are classified into polyphenolic compounds and have been reported to have high antioxidant activities [2][3][4]. Some delivery methods to improve the bioavailability of -mangostin have recently been studied, including microgel [5], solid dispersion [6], microsphere [7], and nanofiber mat [8].…”

α-Mangostin Hydrogel Film Based Chitosan–Alginate for Recurrent Aphthous Stomatitis

“…α-M in the hydrogel affects the hydrodynamic diameter profile of microgels. When α-M is absorbed in the surface of microgel particle and not in filtrated into matrices of the gel, the gel will be fully swollen [42,43]. In this study, α-M in ChAlg/α-M HF was in the surface of the hydrogel film by intermolecular interaction between α-M at the 21st and 22nd hydrogen atom of Alg increasing the number of water that penetrated the network through hydrogen bond, resulting in the increasing of swelling ratio of ChAlg/α-M HF.…”