Correlation between Structures and Antioxidant Activities of Polyvinylpyrrolidone/Garcinia mangostana L. Extract Composite Nanofiber Mats Prepared Using Electrospinning

Abstract

Nanofiber mats of polyvinyl(pyrrolidone) (PVP) with Garcinia mangostana extract (GME) as the encapsulated drug have been developed using electrospinning. SEM images of all electrospun PVP/GME composite nanofiber mats showed that they had similar and smooth morphology, no beads, and spindle shape. Its average diameter decreased and its surface area therefore increased with the decrease of its PVP concentration. The benefit of high surface area is obvious in drug delivery systems for poorly water-soluble drugs. Their FTIR spectra indicated that PVP and GME interacted intermolecularly via hydrogen bonds in the composite nanofiber mats. A conformational change in the C-H chain of PVP occurred in the composite nanofiber mats due to the intermolecular interactions. Their XRD patterns confirmed that they were amorphous because of amorphization during electrospinning. The XRD analyses also strengthened the FTIR studies; namely, GME and PVP formed intermolecular interactions in the electrospun composite nanofiber mats. As a result, GME as the encapsulated drug was molecularly dispersed in the electrospun PVP nanofiber matrix that functioned as a drug delivery system. From the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, the composite nanofiber mats exhibited very high antioxidant activities despite having been exposed to high voltage during electrospinning. Therefore, they are potential antioxidant products for food and pharmaceutics.

Rosmarinic acid‐loaded electrospun nanofibers: In vitro release kinetic study and bioactivity assessment

“…The IC 50 value is an indicator of antioxidant capacity of a product. RosA used in this study exhibited IC 50 values within the range of 1 to 50 μg/mL and 50 to 100 μg/mL corroborating very high and high antioxidant activity [50] of RosA dissolved in acetone and acetate buffer, respectively. RosA is an ester of caffeic acid with 3,4-dihydroxyphenyl lactic acid.…”

Biocompatible and Biodegradable Electrospun Nanofibrous Membranes Loaded with Grape Seed Extract for Wound Dressing Application

“…Natural bioactive phenolic compounds have gained much importance in the past years for promoting health or preventing disease due to their beneficial physiological properties, including antioxidant [1][2][3], anti-inflammatory [4,5], anticarcinogenic [6][7][8], and antimicrobial activities [3,8]. Sources for obtaining polyphenolic compounds are varied, including byproducts and wastes generated by agroindustry [9], which can be used, for instance, as food antioxidants and antimicrobial agents [10].…”

“…In this context, electrospinning has been established as an outstanding technique to entrap bioactive compounds within polymer matrices aiming to be used for drug delivery and wound dressing applications [15][16][17][18]. Recently, electrospun nanofibers have been proposed for stabilizing and controlling the release of various bioactive compounds, such as caffeic acid [8], Centella asiatica [19], and Garcinia mangostana extract [1]. However, little attention has been given to the study and application of electrospinning for the encapsulation of GSE aiming at biomedical applications.…”

The synthesis of nanofiber membranes from acrylonitrile butadiene styrene (ABS) waste using electrospinning for use as air filtration media

“…However, the existence of the beads along the bers indicated that the surface tension still had a strong enough force to encounter the viscoelastic stresses. 27,28 Increasing the solution concentration to 30 wt% also gave a signicant increase to the viscosity (see Table 1), which led to an increase of the ber diameter and a decrease of the number of beads. Similar to the solution with the DMAc solvent, the solution with the DMF solvent produced beads to pure ber morphologies as shown in Fig.…”