Microbial keratitis following corneal transplantation

Das, Sujata; Constantinou, Marios; Ong, Terrence J; Taylor, Hugh R.

doi:10.1111/j.1442-9071.2007.01512.x

Cited by 33 publications

(27 citation statements)

References 17 publications

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“…[48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64] In the present study, bacterial keratitis was significantly more likely to occur in eyes with stromal scarring or corneal edema than in those with stromal dystrophy or keratoconus. Because there were no significant differences in patient compliance with postoperative visits between older and younger patients, it is likely that differences in the prevalence and severity of ocular surface disease were the major contributing factors for these differences.…”

Section: Discussionmentioning

confidence: 96%

“…3,[29][30][31][32] Postoperative complications such as endothelial rejection, [33][34][35][36] glaucoma worsening, [37][38][39][40][41][42][43][44][45][46][47] bacterial keratitis, [48][49][50][51][52][53][54][55][56][57][58][59][60][61] persistent epithelial defects (PEDs), [48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64] and wound dehiscence …”

mentioning

confidence: 99%

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Postoperative Complications After Primary Adult Optical Penetrating Keratoplasty: Prevalence and Impact on Graft Survival

Wagoner

Ba-Abbad

Al-Mohaimeed

et al. 2009

Cornea

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Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 99%

Postoperative Complications After Primary Adult Optical Penetrating Keratoplasty: Prevalence and Impact on Graft Survival

Wagoner

Ba-Abbad

Al-Mohaimeed

et al. 2009

Cornea

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“…A loose suture thread seems to be a risk factor for microbial keratitis following keratoplasty because organisms easily attach to the suture thread and migrate into the cornea. A previous study also reported that 35% of infectious keratitis cases following keratoplasty were related to sutures (2). Thus, biofilm formation on the suture seems to be one mechanism of pathogenicity in infectious keratitis.…”

mentioning

confidence: 99%

Suture-Related Keratitis Caused by Corynebacterium macginleyi

Suzuki¹,

Iihara

Uno³

et al. 2007

J Clin Microbiol

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We report two cases of suture-related keratitis following penetrating keratoplasty. In both cases, Corynebacterium macginleyi was isolated from corneal specimens. Scanning electron microscopy revealed that corynebacteria could aggregate and form a biofilm. The MICs of sulbenicillin and fluoroquinolones were high for both isolates. Our findings show that C. macginleyi can cause keratitis with biofilm formation. CASE REPORT Case 1. A 74-year-old woman underwent penetrating keratoplasty for a corneal opacity. Postoperatively, she was treated with topical corticosteroids (0.1% dexamethasone) and 0.3% gatifloxacin four times daily, and her recovery was uneventful. Four months later, she visited us with a complaint of blurred vision in her right eye. Slit-lamp biomicroscopy revealed an epithelial defect and a moderate degree of stromal infiltration, along with a loose corneal suture thread. We scraped over the surface of the suppurative area of the cornea and removed the loose corneal suture thread. Direct microscopy and bacterial culture of the corneal scraping were performed. The direct microscopy of the corneal scraping demonstrated the presence of gram-positive rods, and confluent growth of corynebacteria occurred after 48 h of incubation at 37°C in a 5% CO 2 -enriched atmosphere on Columbia agar plates supplemented with 5% sheep blood (SBA). Colonies were grayish translucent and less than 0.5 mm in diameter. We considered corynebacteria to be the causative agent of the keratitis. We stopped the topical corticosteroids and 0.3% gatifloxacin and started treatment with topical 0.3% tobramycin and 0.5% cefmenoxime every hour. The corneal lesion responded to these agents promptly, and the corneal infiltration healed within 1 week.Case 2. A 49-year-old man underwent penetrating keratoplasty for bullous keratopathy caused by a birth injury. Postoperatively, he was treated with topical corticosteroids (0.1% dexamethasone) and 0.5% levofloxacin four times daily, and his recovery was uneventful. The antibiotic eye drops were stopped 1 year after surgery. When he visited us 3 years after the surgery, slit-lamp biomicroscopy revealed an epithelial defect and a corneal plaque with a loose corneal suture thread (Fig. 1A). We removed the loose corneal suture thread and performed direct microscopy and bacterial culture of the removed corneal plaque. Direct microscopy demonstrated the presence of numerous gram-positive rods (Fig. 1B), and a large number of small colonies (Ͻ0.5 mm in diameter after 48 h of incubation) were observed on SBA. We diagnosed keratitis caused by corynebacteria, stopped the topical corticosteroids, and initiated treatment with topical 0.3% tobramycin and 0.3% gatifloxacin every hour. The epithelial defect and corneal plaque disappeared within 1 week.Bacteriological findings. The isolates (EC009 in case 1 and EC010 in case 2) were suspected of being lipophilic corynebacteria because small colonies (Ͻ0.5 mm in diameter) were found after 48 h of incubation on SBA. In order to identify corynebacteria, biochem...

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“…49 53 Eighty-one episodes of microbial keratitis in 62 patients after PK were identified in a retrospective analysis from 2000 to 2005 at the Corneal Unit of Royal Victorian Eye and Ear Hospital, Melbourne, Australia. 54 They concluded that a failed graft is a long-term risk factor for graft infection in addition to ocular surface disease and HSV keratitis. de Castro et al 55 reported a case of cryptococcal keratitis after keratoplasty suspected to be a donor-to-host transmission.…”

Section: Endophthalmitis and Microbial Keratitismentioning

confidence: 99%

Eye Banking and Corneal Transplantation Communicable Adverse Incidents

Dubord

Evans

Macsai

et al. 2013

Cornea

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The standardization of definitions for adverse events and reactions will be necessary to support the prevention and transmission of disease. International classification of a unique identification system for donors will be increasingly important for vigilance and traceability in cross-national exportation of human cells, tissues, and cellular- and tissue-based products. Opportunities for continuous improvement exist as does the need for constant vigilance and surveillance.

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Microbial keratitis following corneal transplantation

Abstract: Failed graft is a long-term risk factor for graft infection in addition to ocular surface disease and H. simplex keratitis. All the predisposing risk factors increase the risk of recurrent graft infection.

Cited by 33 publications

References 17 publications

Postoperative Complications After Primary Adult Optical Penetrating Keratoplasty: Prevalence and Impact on Graft Survival

Postoperative Complications After Primary Adult Optical Penetrating Keratoplasty: Prevalence and Impact on Graft Survival

Suture-Related Keratitis Caused by Corynebacterium macginleyi

Eye Banking and Corneal Transplantation Communicable Adverse Incidents

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