Eye Banking and Corneal Transplantation Communicable Adverse Incidents

Abstract

The standardization of definitions for adverse events and reactions will be necessary to support the prevention and transmission of disease. International classification of a unique identification system for donors will be increasingly important for vigilance and traceability in cross-national exportation of human cells, tissues, and cellular- and tissue-based products. Opportunities for continuous improvement exist as does the need for constant vigilance and surveillance.

Infectious keratitis after keratoplasty

“…Infections sourced to intraoperative contamination, infected donor tissue, or previous host disease tends to present earlier in the postoperative course, or within 6-8 weeks, postoperatively [31]. Late postoperative infections tend to be because of environmental pathogens [31].…”

“…Late postoperative infections tend to be because of environmental pathogens [31]. Most cases of infectious keratitis occur during the late postoperative period, defined by most publications as more than 2-4 months after surgery.…”

Report of the Eye Bank Association of America Medical Review Subcommittee on Adverse Reactions Reported From 2007 to 2014

“…15 Donor-to-host transmission of infection or malignancy is a rare but important consideration associated with corneal transplantation. 22 Possible underreporting may result from difficulty in confirming causative role of systemic transmission and the very long latency period of conditions, such as CJD and HIV. In our study, none of the 3 reported systemic infections were definitively confirmed to be because of the donor tissue.…”

Standardization of the exclusion criteria for the HTLV I and II in brazilian eye banks

“…to the extent that with the publication soon of the new RDC for Tissue Banks the tests will be required for ocular tissues 16 . The International Classification of a unique identification system for donors will be increasingly important for surveillance and traceability in transnational export of human cells and tissues 17 . There is always an opportunity for quality improvement with keeping constant watch 17 .…”

“…The International Classification of a unique identification system for donors will be increasingly important for surveillance and traceability in transnational export of human cells and tissues 17 . There is always an opportunity for quality improvement with keeping constant watch 17 . It is important to remember that AIDS epidemic has already presented many challenges for medicine, so we can't ignore the risks of the virus HTLV.…”