Report of the Eye Bank Association of America Medical Review Subcommittee on Adverse Reactions Reported From 2007 to 2014

Edelstein, Sean; DeMatteo, Jennifer; Stoeger, Christopher G.; Macsai, Marian S.; Wang, Chi‐Hsiung

doi:10.1097/ico.0000000000000869

Cited by 89 publications

(80 citation statements)

References 21 publications

(36 reference statements)

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“…This can be explained by long learning curves required for DSAEK and DMEK. Similar to the report by the EBAA between 2007 and 2014, [45] primary GF predominated in our series over the last 12 years. Different from the EBAA report in which Candida species was the most frequent isolated pathogen in post-corneal graft endophthalmitis, [45] Gram-positive microorganisms predominated in our series.…”

Section: Discussionsupporting

confidence: 92%

“…Similar to the report by the EBAA between 2007 and 2014, [45] primary GF predominated in our series over the last 12 years. Different from the EBAA report in which Candida species was the most frequent isolated pathogen in post-corneal graft endophthalmitis, [45] Gram-positive microorganisms predominated in our series. Regarding infectious keratitis, no significant difference was found between the rate of fungal keratitis and keratitis caused by Gram-negative bacteria in our survey; this result is different from that of the EBAA report.…”

Section: Discussionsupporting

confidence: 92%

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A 27-Year Report from the Central Eye Bank of Iran

Javadi

Kanavi

Safi

2020

JOVR

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Purpose: To report the 27-year statistical data from the Central Eye Bank of Iran (CEBI) and its activity. Methods: All CEBI records regarding procured eyes, tissue utilizations, corneal transplants per capita, and indications for keratoplasty from 1991 to 2017 were analyzed. Results: In total, 115,743 whole eyes were donated during the 27-year period. Out of the 114,169 eyes donated between 1994 and 2017, 95,314 eyes were distributed for transplantation, and 95,057 corneas were actually transplanted. The mean annual rate of corneal transplants per capita was 55.10−6 ± 27.10−6. Although penetrating keratoplasty (PKP, 70%) was the most common technique of corneal transplantation during the study period, it exhibited a decreasing trend between 2006 and 2017 (P = 0.048). It was in contrast to Descemet stripping automated endothelial keratoplasty (DSAEK) that demonstrated an increasing trend during the same period (P < 0.001). Keratoconus (KCN, 39.70%) was the most leading indication for keratoplasty over the last three decades followed by bullous keratopathy (BK, 18.5%), corneal scar and opacities (15.7%), and graft failure (GF, 7.5%), with an increasing trend for BK, GF, and KCN. A majority of scleral tissues (83.7%) were utilized for orbital implant protection. Conclusion: An increasing trend in the number of procured eyes was observed over the past 27 years in Iran. The most leading indications for corneal transplantation were KCN and BK. While PKP was the most common keratoplasty technique, DSAEK showed an increasing trend over the last 12 years.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

A 27-Year Report from the Central Eye Bank of Iran

Javadi

Kanavi

Safi

2020

JOVR

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“…Keratitis postcorneal transplant is most commonly due to Candida spp (80% of cases). This is due in part to the most widely used corneal holding medium not containing any antifungal agents [55]. A corneal swab specimen is used to inoculate an agar plate containing nonnutritive medium at the patient's bedside and then transported immediately to the laboratory.…”

Section: E Keratitismentioning

confidence: 99%

A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious Diseases Society of America and the American Society for Microbiologya

Miller

Binnicker

Campbell

et al. 2018

Clinical Infectious Diseases

400

257

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The critical nature of the microbiology laboratory in infectious disease diagnosis calls for a close, positive working relationship between the physician/advanced practice provider and the microbiologists who provide enormous value to the healthcare team. This document, developed by experts in laboratory and adult and pediatric clinical medicine, provides information on which tests are valuable and in which contexts, and on tests that add little or no value for diagnostic decisions. This document presents a system-based approach rather than specimen-based approach, and includes bloodstream and cardiovascular system infections, central nervous system infections, ocular infections, soft tissue infections of the head and neck, upper and lower respiratory infections, infections of the gastrointestinal tract, intra-abdominal infections, bone and joint infections, urinary tract infections, genital infections, and other skin and soft tissue infections; or into etiologic agent groups, including arthropod-borne infections, viral syndromes, and blood and tissue parasite infections. Each section contains introductory concepts, a summary of key points, and detailed tables that list suspected agents; the most reliable tests to order; the samples (and volumes) to collect in order of preference; specimen transport devices, procedures, times, and temperatures; and detailed notes on specific issues regarding the test methods, such as when tests are likely to require a specialized laboratory or have prolonged turnaround times. In addition, the pediatric needs of specimen management are also emphasized. There is intentional redundancy among the tables and sections, as many agents and assay choices overlap. The document is intended to serve as a guidance for physicians in choosing tests that will aid them to quickly and accurately diagnose infectious diseases in their patients.

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“…202 Along with the popularity of EK came an increase in case reports of fungal infections, prompting large database studies that confirmed its rise. [203][204][205] Although rare, the incidence of postkeratoplasty fungal infections (most commonly Candida species) has grown in recent years from 0.014% in a 2013 report 203 to 0.023% in a 2016 report. 204 The additional warming period required for EK processing has been found to be a factor in fungal infections.…”

Section: Intraoperativementioning

confidence: 99%

“…[203][204][205] Although rare, the incidence of postkeratoplasty fungal infections (most commonly Candida species) has grown in recent years from 0.014% in a 2013 report 203 to 0.023% in a 2016 report. 204 The additional warming period required for EK processing has been found to be a factor in fungal infections. 206 In contrast to the discordance of positive bacterial culture donor rims to clinical infection, multiple studies show positive fungal culture donor rims to have predictive value.…”

Section: Intraoperativementioning

confidence: 99%