Microbial Factors in Psoriasis

Rosenberg, Elizabeth

doi:10.1001/archderm.1982.01650150005007

Cited by 43 publications

(10 citation statements)

References 17 publications

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“…The results of the present study revealed that the presence of Candida in the oral cavity is more common among psoriasis patients and is associated with disease severity. The association between Candida and psoriasis was first studied in 1982 by Rosenberg et al . In a comprehensive study, Henseler investigated the association between mucocutaneous candidiasis and skin disease in 44 695 patients with >80 cutaneous disorders .…”

Section: Discussionmentioning

confidence: 99%

Oral Candida colonization and plaque type psoriasis: Is there any relationship?

Lesan

Toosi

Aliakbarzadeh

et al. 2018

J of Invest & Clin Dent

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Section: Discussionmentioning

confidence: 99%

Oral Candida colonization and plaque type psoriasis: Is there any relationship?

Lesan

Toosi

Aliakbarzadeh

et al. 2018

J of Invest & Clin Dent

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“…The linkage between Candida and psoriasis has been investigated since the early 1980s. Two groups of researchers have studied this subject thoroughly: one group from the University of Memphis, Tennessee, USA [10], and another group from the university of Frankfurt, Germany [11].…”

Section: Discussionmentioning

confidence: 99%

Incidence ofCandidain psoriasis – a study on the fungal flora of psoriatic patients

Waldman

Gilhar

Duek³

et al. 2001

Mycoses

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The presence of Candida albicans and other Candida species in saliva and faeces of 50 psoriatic patients compared with a control group of 50 healthy donors was examined quantitatively. The quantity of Candida in saliva and faeces of the psoriatics proved to be significantly higher than in the controls. Candida was detected in 78% of the saliva samples of the psoriatics but in only 50% of the controls, and in the faeces samples in 72% of the psoriatics, but in only 46% of the controls. Qualitative analysis revealed a predominance of Candida albicans (saliva, 77%; faeces, 64%) and Candida rugosa (saliva, 28%; faeces, 28%). We did not find a correlation between the severity of the psoriasis according to the Psoriasis Area and Severity Index and the amount of Candida in the saliva or in the faeces. Our results reinforce the hypothesis that C. albicans is one of the triggers to both exacerbation and persistence of psoriasis. We propose that in psoriatics with a significant quantity of Candida in faeces, an antifungal treatment should be considered as an adjuvant treatment of psoriasis.

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“…Malassezia has been associated with a wide range of other superficial diseases, including acne vulgaris (21,206), dacryocystitis (474), seborrhoeic blepharitis (440), neonatal pustulosis (19,309,336,350), confluent and reticulated papillomatosis (136,215,223,236,366,481,482), onychomycosis (97, 400), nodular hair infection (262), and psoriasis (120,124,140,373,374,376). In many of these reports, the isolation of Malassezia was taken as proof of its involvement in the disease, an assumption that may not be correct due to its presence on the skin as a commensal.…”

Section: Other Superficial Diseasesmentioning

confidence: 99%

Immunology of Diseases Associated withMalasseziaSpecies

2002

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SUMMARY Malassezia species are members of the human cutaneous commensal flora, in addition to causing a wide range of cutaneous and systemic diseases in suitably predisposed individuals. Studies examining cellular and humoral immune responses specific to Malassezia species in patients with Malassezia-associated diseases and healthy controls have generally been unable to define significant differences in their immune response. The use of varied antigenic preparations and strains from different Malassezia classifications may partly be responsible for this, although these problems can now be overcome by using techniques based on recent work defining some important antigens and also a new taxonomy for the genus. The finding that the genus Malassezia is immunomodulatory is important in understanding its ability to cause disease. Stimulation of the reticuloendothelial system and activation of the complement cascade contrasts with its ability to suppress cytokine release and downregulate phagocytic uptake and killing. The lipid-rich layer around the yeast appears to be pivotal in this alteration of phenotype. Defining the nonspecific immune response to Malassezia species and the way in which the organisms modulate it may well be the key to understanding how Malassezia species can exist as both commensals and pathogens.

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Microbial Factors in Psoriasis

Cited by 43 publications

References 17 publications

Oral Candida colonization and plaque type psoriasis: Is there any relationship?

Oral Candida colonization and plaque type psoriasis: Is there any relationship?

Incidence ofCandidain psoriasis – a study on the fungal flora of psoriatic patients

Immunology of Diseases Associated withMalasseziaSpecies

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