Incidence ofCandidain psoriasis – a study on the fungal flora of psoriatic patients

Abstract

The presence of Candida albicans and other Candida species in saliva and faeces of 50 psoriatic patients compared with a control group of 50 healthy donors was examined quantitatively. The quantity of Candida in saliva and faeces of the psoriatics proved to be significantly higher than in the controls. Candida was detected in 78% of the saliva samples of the psoriatics but in only 50% of the controls, and in the faeces samples in 72% of the psoriatics, but in only 46% of the controls. Qualitative analysis revealed a predominance of Candida albicans (saliva, 77%; faeces, 64%) and Candida rugosa (saliva, 28%; faeces, 28%). We did not find a correlation between the severity of the psoriasis according to the Psoriasis Area and Severity Index and the amount of Candida in the saliva or in the faeces. Our results reinforce the hypothesis that C. albicans is one of the triggers to both exacerbation and persistence of psoriasis. We propose that in psoriatics with a significant quantity of Candida in faeces, an antifungal treatment should be considered as an adjuvant treatment of psoriasis.

Molecular Analysis of Fungal Microbiota in Samples from Healthy Human Skin and Psoriatic Lesions

“…Although of unknown etiology, trigger factors, including physical trauma and streptococcal infections, may provoke clinical manifestations (51). Fungal organisms, including Candida albicans (63) and Malassezia furfur (3), have also been associated with the development of psoriatic skin lesions, and differences have been observed in the Malassezia species distributions in healthy subjects and patients with psoriasis (23,24,46).…”

Childhood Herpes Zoster-Triggered Guttate Psoriasis

“…Fungal Candidosis [20] HZ in children is uncommon but is probably underrecognized [17]. This child presented with chickenpox at the age of 1, which is a typical risk factor for childhood HZ.…”

“…Despite the clear relationship between the streptococcal infection and recurrent acute guttate psoriasis or chronic plaque psoriasis, there is currently no evidence that antibiotics and/or tonsillectomy are beneficial for these patients [7]. Psoriasis has also been described after throat infections by Candida albicans [20].…”

Psoriasis: Epidemiology, Clinical and Histological Features, Triggering Factors, Assessment of Severity and Psychosocial Aspects

“…A strong association is the induction of guttate psoriasis by a preceding tonsilar Streptococcus pyogenes infection. Disease exacerbation has been associated with skin and/or gut colonization by Staphylococcus aureus, Malassezia and Candida albicans (Noah 1990;Waldman, Gilhar et al 2001). Streptococcal infections precede the development or worsening of psoriasis in more than 90% of patients with type I psoriasis (Weisenseel, Laumbacher et al 2002).…”