Microbial Etiology and Antimicrobial Therapy of Peri-implantitis: A Comprehensive Review

Hussain, Mohammad Rashid; Abullais, Shahabe Saquib; Naqash, Talib Amin; Bhat, Mohammad Yunis Saleem

doi:10.2174/1874210601812011113

Cited by 6 publications

(5 citation statements)

References 48 publications

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“…By eradicating subgingival microorganisms still present after traditional mechanical periodontal therapy, systemic periodontal antibiotic therapy seeks to supplement mechanical periodontal treatment and boost the host defense system in overcoming the infection. [ 29 ].…”

Section: Reviewmentioning

confidence: 99%

“…However, navigating these new frontiers responsibly is crucial, ensuring rigorous research, evidence-based practice, and patient-centered care. With interdisciplinary collaboration, ethical considerations, and a commitment to advancing oral health, the future holds the potential for a paradigm shift in how oral diseases are approached and treated, ultimately leading to improved patient outcomes and a reimagined standard of care [28][29][30].…”

Section: Future Perspectivesmentioning

confidence: 99%

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Immunomodulators and Their Applications in Dentistry and Periodontics: A Comprehensive Review

Pahade,

Bajaj,

Reche

et al. 2023

Cureus

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The intricate interplay between the immune system and oral health has revealed opportunities for novel therapeutic interventions in dentistry and periodontics. This review article delves into the pivotal role of immunomodulators in orchestrating immune responses within the oral cavity and their applications in managing various oral and periodontal conditions. The oral environment faces many challenges, from microbial infections to tissue injuries, necessitating a precise immune response for optimal oral health maintenance. Characterized by their ability to modulate immune reactions, immunomodulators emerge as versatile tools for maintaining immune equilibrium. This is a comprehensive overview of the mechanisms through which immunomodulators exert their effects, shedding light on their dual role as regulators of both pro-inflammatory and anti-inflammatory pathways. The diverse applications of immunomodulators within dentistry are explored in depth. Immunomodulators exhibit promising outcomes from managing common oral conditions like gingivitis, periodontitis, and oral ulcers to enhancing the integration of dental implants and promoting wound healing post-surgery. This article highlights the various types of immunomodulatory agents utilized in dental practice, elucidating their mechanisms of action, routes of administration, dosages, and potential side effects.

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Section: Reviewmentioning

confidence: 99%

Section: Future Perspectivesmentioning

confidence: 99%

Immunomodulators and Their Applications in Dentistry and Periodontics: A Comprehensive Review

Pahade,

Bajaj,

Reche

et al. 2023

Cureus

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“…Bacterial infections are a common cause of endoosseous mini-implant failure. 15 Various studies have suggested reducing inflammation rates by taking daily mouthwash safely. 16 17 According to Nugraha et al, they concluded that Robusta Green Coffee Bean (RGCB) ethanol extract might be effective against periimplantitis bacteria in vitro , and chlorogenic acid in RGCB has antibacterial, anti-inflammatory, antioxidant, pro-osteogenic properties, and antibone resorption.…”

Section: Introductionmentioning

confidence: 99%

The Orthodontic Mini-Implants Failures Based on Patient Outcomes: Systematic Review

Tarigan,

Sufarnap,

Bahirrah

2023

Eur J Dent

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Anchorage is a challenge and essential issue for an orthodontist in determining the success of orthodontic treatment. Orthodontic anchorage is defined as resistance to unwanted tooth movement. Mini-implant is one of the devices that can be used as an anchor in orthodontic treatment. Many cases have reported successful treatment using mini-implant, but there are cases where mini-implants may fail. Failure of mini-implants can affect orthodontic treatment, and it is known that several factors may lead to mini-implant loss in orthodontic treatment. This systematic review aimed to determine the factors influencing mini-implant failure in orthodontic treatment. Articles were selected from electronic databases (PubMed, Google Scholar, The Cochrane Library, ScienceDirect) from January 2015 until 2023 according to the PRISMA method (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) under the PEOS (Population-Exposure-Outcome-StudyType) framework questions for systematic review. The study was registered in the International Prospective Register of Systematic Reviews (PROSPERO) database (CRD42022337684). All data collected were in English, and filtering was done by eliminating duplicate data, meta-analysis, case reports, case series, mini-reviews, and animal studies. The analysis was further divided into three groups, that is, patient-related, implant-related, and operator-related and operator-related (A graphical abstract provided as a Supplementary information [available in the online version]). Twenty-one articles were identified according to the inclusion criteria in the form of retrospective, prospective, in vivo, and randomized controlled trial studies. Mini-implant failures due to patient-related showed six etiological factors, failures due to implant-related had eight etiological factors, and only one factor was operator-related, which may lead to mini-implant failure. The data was extracted without a computerized system and only in English. Mini-implant failure can be caused by many factors; we could not accuse one major factor as a cause. However, the quality or condition of the bones and oral hygiene are factors that play a significant role in obtaining the stability of implants. Mini-implant failure is highly influenced by poor oral hygiene and peri-implant inflammation. Comprehensive diagnostic prior to mini-implant insertion should be appropriately considered. This systematic review describes several factors that can influence mini-implant failure, divided into three groups: patient-related, implant-related, and operator-related (A graphical abstract provided as a Supplementary information [available in the online version]).

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“…Peri-implantitis is a polymicrobial illness that is mixed and changeable but is dominated by gram-negative anaerobic bacteria. 9 Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), and Prevotella intermedia (Pi) were discovered to be more frequent in peri-implantitis than in peri-implant health. 10 Pg produces virulence factors like capsules, fimbriae, and proteases that aid colonization and the activation of dysbiotic inflammatory responses.…”

Section: Introductionmentioning

confidence: 99%

Anti–Peri-implantitis Bacteria's Ability of Robusta Green Coffee Bean (Coffea Canephora) Ethanol Extract: An In Silico and In Vitro Study

et al. 2022

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Objective This study was aimed to investigate RGCBE extract as antioxidant and anti–peri-implantitis bacteria through in vitro study and its potential as antioxidant, antibacterial, anti-inflammatory, antibone resorption, and proosteogenic through in silico study. Materials and Methods Absorption, distribution, metabolism, excretion and toxicity prediction, molecular docking simulation, and visualization of chlorogenic acid (CGA) and coumaric acid (CA) as anti-inflammatory, antioxidant, and antibacterial were investigated in silico. Inhibition zone by diffusion method, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) of RGCBE extract against Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), Fusobacterium nucleatum (Fn), and Prevotella intermedia (Pi) were done. Statistical Analysis the analysis of variance (ANOVA) difference test, and the post-hoc Tukey's Honest Significant Different (HSD) with a different significance value of p<0.05 Results GCA and CA compounds are good drug molecules and it has low toxicity. Chlorogenic acid have higher binding activity than coumaric acid to tumor necrosis factor (TNF)-α, nuclear factor (NF)-κB, receptor activation NF-κB (RANK) and its ligand (RANKL), interleukin (IL)-6, IL-10, runt related transcription factor (RUNX2), receptor activator nuclear Kappa beta Ligand-osteoprotegrin osteocalcin (RANKL-OPG), osteocalcin, nuclear factor associated T-cell 1 (NFATc1), tartate resistant acid phosphatase (TRAP), peptidoglycan, flagellin, dectin, Hsp70, and Hsp10 protein. RGCB ethanol extract has high antioxidant ability and it has MIC, MBC, and inhibit the growth of Aa, Pg, Fn, and Pi at 50% concentration with significantly different (p=0.0001 and<0.05). Conclusion RGCB ethanol extract has high antioxidant ability and 50% RGCB ethanol extract may act as strong anti–peri-implantitis bacteria in vitro. In addition, CGA in RGCB potential as antioxidant, antibacterial, anti-inflammatory, antibone resorption, and proosteogenic in silico.

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Microbial Etiology and Antimicrobial Therapy of Peri-implantitis: A Comprehensive Review

Cited by 6 publications

References 48 publications

Immunomodulators and Their Applications in Dentistry and Periodontics: A Comprehensive Review

Immunomodulators and Their Applications in Dentistry and Periodontics: A Comprehensive Review

The Orthodontic Mini-Implants Failures Based on Patient Outcomes: Systematic Review

Anti–Peri-implantitis Bacteria's Ability of Robusta Green Coffee Bean (Coffea Canephora) Ethanol Extract: An In Silico and In Vitro Study

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