Microbial biocompatibility of phosphonium- and ammonium-based ionic liquids

Sivapragasam, Magaret; Raj, Jaganathan Joshua; Lévêque, Jean–Marc; Moniruzzaman, Muhammad; Mutalib, M.I. Abdul

doi:10.1016/j.molliq.2018.10.022

Cited by 33 publications

(22 citation statements)

References 54 publications

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“…It was found that they exhibited different level of sensitivity to ILs in terms of growth kinetics and viability. Three debatable notions have noticed from different studies: i) there are differences between the effects of ILs on Gram‐positive and Gram‐negative bacteria, ii) no discernible difference between the effects on the two types of bacteria, iii) insufficient evidence to draw definitive conclusions on the effects on the bacteria types . For example, Gram‐positive B. subtilis was more resistant to imidazolium‐based hydrophilic ILs, whereas Gram‐negative Pseudomonas aeruginosa exhibited more tolerance to choline‐ and phosphonium‐based ILs .…”

Section: Toxicity Of Ionic Liquids Toward Microorganismsmentioning

confidence: 99%

“…Third‐generation ILs are based on more hydrophobic and stable anions, such as sugars, amino or organic acids, alkylsulfates, or alkylphosphates. In general, increased overall lipophilicity results in an increase in toxicity which is due to the interference with biological membranes . To obtain low toxicity, good stability, and biological activity, anions derived from naturally occurring substances are suitable as counterions to prepare ILs .…”

Section: Toxicity Of Ionic Liquids Toward Microorganismsmentioning

confidence: 99%

“…They have remarkable features that can be easily custom‐made by a plethora of cations and anions, making them task‐specific solvents and agents. Because of these tailor‐made properties, ILs have been used in a wide variety of applications including biotechnology, chemical engineering, separation processes, material sciences, green chemistry, pharmaceutics, and many others. The use of ILs in biological applications has gained popularity in recent years because ILs are less toxic than that of many conventional organic solvents.…”

Section: Introductionmentioning

confidence: 99%

“…This is why they easily migrate into the environment and affect living biota. Therefore, there is valid expectation that the toxicity of ILs be determined before they are considered for any applications . In recent years, the cytotoxicity, eco‐toxicity, and microbial toxicity of ILs have been studied extensively.…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies have reported the different cytotoxic effects of ILs on Gram‐positive and Gram‐negative bacteria. The differences in cell wall composition play an important role in the interaction between ILs and bacterial cell walls . Several reviews have focused on the toxicity and biodegradability of ILs .…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

An Overview on the Toxicological Properties of Ionic Liquids toward Microorganisms

Sivapragasam

Moniruzzaman

Goto

2020

Biotechnology Journal

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Ionic liquids (ILs), a class of materials with unique physicochemical properties, have been used extensively in the fields of chemical engineering, biotechnology, material sciences, pharmaceutics, and many others. Because ILs are very polar by nature, they can migrate into the environment with the possibility of inclusion in the food chain and bioaccumulation in living organisms. However, the chemical natures of ILs are not quintessentially biocompatible. Therefore, the practical uses of ILs must be preceded by suitable toxicological assessments. Among different methods, the use of microorganisms to evaluate IL toxicity provides many advantages including short generation time, rapid growth, and environmental and industrial relevance. This article reviews the recent research progress on the toxicological properties of ILs toward microorganisms and highlights the computational prediction of various toxicity models.

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Section: Toxicity Of Ionic Liquids Toward Microorganismsmentioning

confidence: 99%

Section: Toxicity Of Ionic Liquids Toward Microorganismsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

An Overview on the Toxicological Properties of Ionic Liquids toward Microorganisms

Sivapragasam

Moniruzzaman

Goto

2020

Biotechnology Journal

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Bioionic Liquids: Enabling a Paradigm Shift Toward Advanced and Smart Biomedical Applications

Kanjilal

Zhu

Krishnadoss

et al. 2023

Advanced Intelligent Systems

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Figure 11. Application of cholinium BILs in encapsulation and targeted delivery. Usage of cholinium BILs enhances the biocompatibility of aggregated structures lowering the propensity of attack and metabolic breakdown by the immune system prior to reaching the targeted delivery spot. a) Encapsulation and delivery of nucleic acids using DNA amphiphiles, self-assembled with lysosomal phospholipid base choline BIL. Reproduced with permission. [133] Copyright 2020, John Wiley and Sons. b) Ester-functionalized SAILs based on nicotine BILs forming aggregates. Reproduced with permission. [130] Copyright 2017, Elsevier. c) Cholinium and other ammonium IL-based drug nanocarriers where chloride anions of the polymer chain ion are exchanged with the pharmaceutical anions for improved drug delivery. Reproduced with permission. [129] Copyright 2021, MDPI.

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The Effect of Additives on the Viscosity and Dissolution of Cellulose in Tetrabutylphosphonium Hydroxide

et al. 2019

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An electrolyte solution of tetrabutylphosphonium hydroxide (TBPH) in water can dissolve over2 0wt% of cellulose in minutes and therefore constitutes ap romising alternative green solvents ystem comparedt ok nown imidazolium-or dimethylacetamide-based systems. Overcoming the disadvantage of the extremelyh igh viscosity of TBPH/cellulose solutionsc an facilitate their use for various applications. In this study,t he application of cosolvents for the reduction,a nd thus adjustability, of the viscosity is addressed. Even well-knowna ntisolvents can be easily deployed, resulting in ad ramatic drop in viscosity. High concentrations of cosolvents (excluding ethanol) are tolerated without precipitation of the dissolved cellulose. Furthermore, the effecto ft he cosolvents on the additional dissolution of cellulose is discussed. The amount of dissolved cellulose is quantified by 13 CNMR spectroscopy.[a] M.

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Microbial biocompatibility of phosphonium- and ammonium-based ionic liquids

Cited by 33 publications

References 54 publications

An Overview on the Toxicological Properties of Ionic Liquids toward Microorganisms

An Overview on the Toxicological Properties of Ionic Liquids toward Microorganisms

Bioionic Liquids: Enabling a Paradigm Shift Toward Advanced and Smart Biomedical Applications

The Effect of Additives on the Viscosity and Dissolution of Cellulose in Tetrabutylphosphonium Hydroxide

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