Bioionic Liquids: Enabling a Paradigm Shift Toward Advanced and Smart Biomedical Applications

Kanjilal, Baishali; Zhu, Yangzhi; Krishnadoss, Vaishali; Unagolla, Janitha M.; Saemian, Parnian; Caci, Alessia; Cheraghali, Danial; Dehzangi, Iman; Khademhosseini, Ali; Noshadi, Iman

doi:10.1002/aisy.202200306

Cited by 5 publications

(2 citation statements)

References 142 publications

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“…Starting from molten salt electrolytes in the 1960s, we have reached the land of (almost) infinite possibilities where any property or application you can think of is possible, at least, theoretically . For example, ILs have been successfully applied in organic synthesis (both as reaction media and catalysts), − electrochemistry, − biomass conversion and biotechnology, − extraction and separation, − and many other fields. ,− …”

Section: Introductionmentioning

confidence: 99%

Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms

Egorova,

Kibardin,

Posvyatenko

et al. 2024

Chem. Rev.

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The review presents a detailed discussion of the evolving field studying interactions between ionic liquids (ILs) and biological systems. Originating from molten salt electrolytes to present multiapplication substances, ILs have found usage across various fields due to their exceptional physicochemical properties, including excellent tunability. However, their interactions with biological systems and potential influence on living organisms remain largely unexplored. This review examines the cytotoxic effects of ILs on cell cultures, biomolecules, and vertebrate and invertebrate organisms. Our understanding of IL toxicity, while growing in recent years, is yet nascent. The established findings include correlations between harmful effects of ILs and their ability to disturb cellular membranes, their potential to trigger oxidative stress in cells, and their ability to cause cell death via apoptosis. Future research directions proposed in the review include studying the distribution of various ILs within cellular compartments and organelles, investigating metabolic transformations of ILs in cells and organisms, detailed analysis of IL effects on proteins involved in oxidative stress and apoptosis, correlation studies between IL doses, exposure times and resulting adverse effects, and examination of effects of subtoxic concentrations of ILs on various biological objects. This review aims to serve as a critical analysis of the current body of knowledge on IL-related toxicity mechanisms. Furthermore, it can guide researchers toward the design of less toxic ILs and the informed use of ILs in drug development and medicine.

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Section: Introductionmentioning

confidence: 99%

Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms

Egorova,

Kibardin,

Posvyatenko

et al. 2024

Chem. Rev.

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show abstract

“…Precise control over ion transport and charge mobility via external stimuli offers considerable opportunities for developing next-generation smart materials, which are crucial in various fields such as drug delivery, [1,2] biomedical engineering, [3,4] and sensors. [5,6] Over the years, various stimuli-responsive materials with adaptive responses triggered by particular stimuli, including heat, [7,8] pH, [9,10] electricity, [11,12] pressure, [13,14] and light [15,16] have been applied to artificial ion channels owing to their remote controllability, high sensitivity, and reversibility.…”

Section: Introductionmentioning

confidence: 99%

Guard Cell‐Inspired Ion Channels: Harnessing the Photomechanical Effect via Supramolecular Assembly of Cross‐Linked Azobenzene/Polymers

Chen,

Hsieh,

Lin

et al. 2023

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Stimuli‐responsive ion nanochannels have attracted considerable attention in various fields because of their remote controllability of ionic transportation. For photoresponsive ion nanochannels, however, achieving precise regulation of ion conductivity is still challenging, primarily due to the difficulty of programmable structural changes in confined environments. Moreover, the relationship between noncontact photo‐stimulation in nanoscale and light‐induced ion conductivity has not been well understood. In this work, a versatile design for fabricating guard cell‐inspired photoswitchable ion channels is presented by infiltrating azobenzene‐cross‐linked polymer (AAZO‐PDAC) into nanoporous anodic aluminum oxide (AAO) membranes. The azobenzene‐cross‐linked polymer is formed by azobenzene chromophore (AAZO)‐cross‐linked poly(diallyldimethylammonium chloride) (PDAC) with electrostatic interactions. Under UV irradiation, the trans‐AAZO isomerizes to the cis‐AAZO, causing the volume compression of the polymer network, whereas, in darkness, the cis‐AAZO reverts to the trans‐AAZO, leading to the recovery of the structure. Consequently, the resultant nanopore sizes can be manipulated by the photomechanical effect of the AAZO‐PDAC polymers. By adding ionic liquids, the ion conductivity of the light‐driven ion nanochannels can be controlled with good repeatability and fast responses (within seconds) in multiple cycles. The ion channels have promising potential in the applications of biomimetic materials, sensors, and biomedical sciences.

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Metal oxide ion gated transistors based sensors

Li,

Yao,

Wang

et al. 2024

Sci. China Technol. Sci.

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Bioionic Liquids: Enabling a Paradigm Shift Toward Advanced and Smart Biomedical Applications

Cited by 5 publications

References 142 publications

Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms

Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms

Guard Cell‐Inspired Ion Channels: Harnessing the Photomechanical Effect via Supramolecular Assembly of Cross‐Linked Azobenzene/Polymers

Metal oxide ion gated transistors based sensors

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