Microbial and Viral Communities and Their Antibiotic Resistance Genes Throughout a Hospital Wastewater Treatment System

Petrovich, Morgan; Zilberman, Adi; Kaplan, Aviv; Eliraz, Gefen R.; Wang, Yübo; Langenfeld, Kathryn; Duhaime, Melissa B.; Wigginton, Krista; Poretsky, Rachel; Avisar, Dror; Wells, George F.

doi:10.3389/fmicb.2020.00153

Cited by 82 publications

(46 citation statements)

References 72 publications

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“…In contrast, there are sources questioning the active role of phages in spreading antibiotic resistance genes in waters. Petrovich et al [65], in their recent study, could not find strong evidence for phages as vectors for those genes in a hospital wastewater treatment system, suggesting that false-positive samples are possible. One must be aware that the use of antibiotics in fish hatcheries will result in accumulated and unabsorbed antibiotics that are likely to affect phage-host coevolution outside the host [66].…”

Section: Unfavorable Impact Of Phages On Aquatic Reservoirsmentioning

confidence: 95%

Phages as a Cohesive Prophylactic and Therapeutic Approach in Aquaculture Systems

2020

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Facing antibiotic resistance has provoked a continuously growing focus on phage therapy. Although the greatest emphasis has always been placed on phage treatment in humans, behind phage application lies a complex approach that can be usefully adopted by the food industry, from hatcheries and croplands to ready-to-eat products. Such diverse businesses require an efficient method for combating highly pathogenic bacteria since antibiotic resistance concerns every aspect of human life. Despite the vast abundance of phages on Earth, the aquatic environment has been considered their most natural habitat. Water favors multidirectional Brownian motion and increases the possibility of contact between phage particles and their bacterial hosts. As the global production of aquatic organisms has rapidly grown over the past decades, phage treatment of bacterial infections seems to be an obvious and promising solution in this market sector. Pathogenic bacteria, such as Aeromonas and Vibrio, have already proved to be responsible for mass mortalities in aquatic systems, resulting in economic losses. The main objective of this work is to summarize, from a scientific and industry perspective, the recent data regarding phage application in the form of targeted probiotics and therapeutic agents in aquaculture niches.

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Section: Unfavorable Impact Of Phages On Aquatic Reservoirsmentioning

confidence: 95%

Phages as a Cohesive Prophylactic and Therapeutic Approach in Aquaculture Systems

2020

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“…Ibrahim et al (2018) detected human adenovirus in the effluent of two HWW treatment units. Caudovirales, Myoviridae, Podoviridae, and Siphoviridae were commonly detected in HWWs of Israel [20] , [70] . Wang et al (2005) found SARS-coronavirus in HWW of China, which was persistent for up to two days at 20 °C and 14 days at 4 °C, while Gundy et al (2009) also found that there was a 99.9% reduction of the coronavirus after 12 days when the water temperature was 23 °C [71] , [72] , [73] .…”

Section: Characteristics Of Hospital Wastewatermentioning

confidence: 98%

“…Many of the recalcitrant organic compounds present in HWW, such as PhACs, are highly toxic with very low drinking water equivalent limit (DWEL) values making them a considerable threat to the environment [19] . Viruses, ARB, and ARG continue to survive even after the treatment of HWW, and their release to the aquatic ecosystem imposes a significant threat to the environment [6] , [20] .…”

Section: Introductionmentioning

confidence: 99%

A review on hospital wastewater treatment: A special emphasis on occurrence and removal of pharmaceutically active compounds, resistant microorganisms, and SARS-CoV-2

Majumder

Gupta

Ghosal

et al. 2021

Journal of Environmental Chemical Engineering

184

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“…Hospital sewage wastewaters are also a source of contamination for urban aquatic environment. Hospital sewage is considered a hotspot for HGT of ARG since its contains multi-resistant bacteria, viruses [ 84 ], antibiotics and biocides [ 14 ]. CPE is also commonly present in hospital sewage wastewater [ 85 ].…”

Section: Presence Of Cpb In Aquatic Environments: a Simply Remnantmentioning

confidence: 99%

The Hydric Environment: A Hub for Clinically Relevant Carbapenemase Encoding Genes

2020

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Carbapenems are β-lactams antimicrobials presenting a broad activity spectrum and are considered as last-resort antibiotic. Since the 2000s, carbapenemase producing Enterobacterales (CPE) have emerged and are been quickly globally spreading. The global dissemination of carbapenemase encoding genes (CEG) within clinical relevant bacteria is attributed in part to its location onto mobile genetic elements. During the last decade, carbapenemase producing bacteria have been isolated from non-human sources including the aquatic environment. Aquatic ecosystems are particularly impacted by anthropic activities, which conduce to a bidirectional exchange between aquatic environments and human beings and therefore the aquatic environment may constitute a hub for CPE and CEG. More recently, the isolation of autochtonous aquatic bacteria carrying acquired CEG have been reported and suggest that CEG exchange by horizontal gene transfer occurred between allochtonous and autochtonous bacteria. Hence, aquatic environment plays a central role in persistence, dissemination and emergence of CEG both within environmental ecosystem and human beings, and deserves to be studied with particular attention.

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Microbial and Viral Communities and Their Antibiotic Resistance Genes Throughout a Hospital Wastewater Treatment System

Cited by 82 publications

References 72 publications

Phages as a Cohesive Prophylactic and Therapeutic Approach in Aquaculture Systems

Phages as a Cohesive Prophylactic and Therapeutic Approach in Aquaculture Systems

A review on hospital wastewater treatment: A special emphasis on occurrence and removal of pharmaceutically active compounds, resistant microorganisms, and SARS-CoV-2

The Hydric Environment: A Hub for Clinically Relevant Carbapenemase Encoding Genes

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