Microarray analysis of mucosal biopsy specimens in neonates with rectal bleeding: Is it really an allergic disease?

Ohtsuka, Yoshikazu; Jimbo, Keisuke; Inage, Eisuke; Mori, Mari; Yamakawa, Yoko; Aoyagi, Yo; Suzuki, Mitsuyoshi; Kudo, Toshifumi; Suzuki, Ryuyo; Shimizu, Toshiaki

doi:10.1016/j.jaci.2012.01.042

Cited by 28 publications

(21 citation statements)

References 9 publications

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“…Furthermore, a study that examined gene expression in bowel biopsy samples from infants with IRB did not find any evidence of an allergic mechanism at the cellular level. 9 In the current study, infants with IRB did not exhibit a higher rate of clinical signs for food and drug allergies or any other hypersensitivity symptoms (defined as asthma, atopic dermatitis or allergic rhinitis) in their early childhood compared with the control group. This supports the notion that the etiology of IRB is not an allergic mechanism.…”

Section: Irb and Childhood Hypersensitivity O Reiter Et Almentioning

confidence: 46%

“…5 Studies aimed at evaluating the involvement of allergic mechanisms among infants with rectal bleeding have shown varying results. [6][7][8][9] More recent studies have demonstrated a relatively low rate (12.5 to 18%) 6,7 of evidence to support allergic colitis among infants with IRB. These studies found IRB to be a benign and selflimiting phenomenon whose cause is mostly unknown.…”

Section: Introductionmentioning

confidence: 99%

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Neonatal isolated rectal bleeding and the risk of hypersensitivity syndromes

et al. 2013

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Section: Irb and Childhood Hypersensitivity O Reiter Et Almentioning

confidence: 46%

Section: Introductionmentioning

confidence: 99%

Neonatal isolated rectal bleeding and the risk of hypersensitivity syndromes

et al. 2013

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“…• Rapid generation of immunologic tolerance may account for FPIAP rather than a true allergic reaction [74,75] Cell-mediated hypersensitivity to food antigens may arise through disruption in mucosal barrier [64] Resultant injury to small bowel mucosa appears to occur through mechanisms similar to celiac disease [17,65] Cytokine milieu From serum and mucosal biopsy:…”

Section: Managementmentioning

confidence: 99%

“…• TH1-, TH2-, and TH17-transcripts not elevated • regulatory T cell-related transcripts expressed at high levels [75,77,78] From sera:…”

Section: Managementmentioning

confidence: 99%

Food Protein-Induced Enterocolitis Syndrome, Allergic Proctocolitis, and Enteropathy

Feuille

Nowak‐Węgrzyn

2015

Curr Allergy Asthma Rep

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Food protein-induced enterocolitis (FPIES), allergic proctocolitis (FPIAP), and enteropathy (FPE) are among a number of immune-mediated reactions to food that are thought to occur primarily via non-IgE-mediated pathways. All three are typically present in infancy and are triggered most commonly by cow's milk protein. The usual presenting features are vomiting with lethargy and dehydration in FPIES; bloody and mucous stools in FPIAP; and diarrhea with malabsorption and failure to thrive in FPE. Diagnosis is based on convincing history and resolution of symptoms with food avoidance; confirmatory diagnostic testing other than food challenge is lacking. The mainstay of management is avoidance of the suspected inciting food, with interval challenge to assess for resolution, which usually occurs in the first years of life. Studies published in the past few years clarify common presenting features, report additional culprit foods, address potential biomarkers, and suggest new management strategies.

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“…Unlike other eosinophilic gastrointestinal disorders (EGID), eosinophilic colitis is usually a non-immunoglobulin E (IgE)-associated disease where a T lymphocyte-mediated process has been suggested as the underlying mechanism [5]. Recently, a microarray analysis of mucosal biopsy specimens demonstrated that the expression of CCL11 and CXCL13, but not TH1-, TH2-, or TH17-related molecules, was significantly enhanced in these patients [6]. Although the condition is largely considered a disease of small infants, a recent report described FPIAP also in older children (age 2-14 years), with features remarkably similar to those observed in infancy [7].…”

Section: Introductionmentioning

confidence: 99%

Food Protein-Induced Non-Immunoglobulin E-Mediated Allergic Colitis in Infants and Older Children: What Cytokines Are Involved?

Ozen

Gülcan²,

Ercan

et al. 2015

Int Arch Allergy Immunol

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Background: Food protein-induced allergic proctocolitis (FPIAP) is mostly a non-immunoglobulin E-mediated disease where a T-cell-mediated reaction to cow's milk protein has been suggested. We determined the expression of transforming growth factor (TGF)-β, TGF-β receptor-1, tumor necrosis factor (TNF)-α, CD86, and CD23 on the colon mucosa to investigate their roles in the pathogenesis of the two subtypes of FPIAP, i.e. infantile FPIAP and FPIAP in older children. Methods: Group 1 comprised children with infantile FPIAP (age <6 months, n = 21), group 2 referred to FPIAP in older children (age >1.5 years, n = 7), and group 3 included children with juvenile hyperplastic polyps (n = 22). Immunohistochemical staining of colonic biopsy specimens was performed. Results: The expression of TNF-α was signiﬁcantly higher in groups 1 and 2 compared to group 3. Group 2 patients had a signiﬁcantly lower TGF-β expression compared to the other groups. The expression of CD86 was higher in group 1 than in group 3 (p = 0.012). Eosinophil counts per high-power field in the lamina propria were signiﬁcantly correlated with CD86 expression (p = 0.026, r = 0.388). Conclusion: Our results suggest that TNF-α is implicated in the pathogenesis of both types of FPIAP. The decreased activity of TGF-β receptor-1 accompanied by the increased expression of CD86 in infants and the decreased activity of TGF-β in older children appear to play a role in the development of FPIAP.

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Microarray analysis of mucosal biopsy specimens in neonates with rectal bleeding: Is it really an allergic disease?

Cited by 28 publications

References 9 publications

Neonatal isolated rectal bleeding and the risk of hypersensitivity syndromes

Neonatal isolated rectal bleeding and the risk of hypersensitivity syndromes

Food Protein-Induced Enterocolitis Syndrome, Allergic Proctocolitis, and Enteropathy

Food Protein-Induced Non-Immunoglobulin E-Mediated Allergic Colitis in Infants and Older Children: What Cytokines Are Involved?

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