Neonatal isolated rectal bleeding and the risk of hypersensitivity syndromes

Reiter, Ofer; Morag, Iris; Mazkereth, Ram; Strauss, Tzipora; Maayan-Metzger, Ayala

doi:10.1038/jp.2013.129

Cited by 3 publications

(4 citation statements)

References 16 publications

(17 reference statements)

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“…Our findings are in line with previous studies suggesting that the lack of breast milk has been significantly associated with IRB 1‐4 . Evidence suggested that a shorter period of breastfeeding was a significant predictor for IRB 1‐4 5 …”

Section: Variables Cases (N=71) Controls (N=281) Psupporting

confidence: 93%

“…Our findings are in line with previous studies suggesting that the lack of breast milk has been significantly associated with IRB. [1][2][3][4] Evidence suggested that a shorter period of breastfeeding was a significant predictor for IRB. [1][2][3][4] The alteration in the composition of the intestinal microbiome in formula-fed infants has been associated with an increase of pro-inflammatory bacterial taxa and intestinal permeability, which could explain the clinical appearance of rectal bleeding.…”

Section: B R I E F R E P O R T Neonatal Isolated Rectal Bleeding: a Case-control Studymentioning

confidence: 99%

“…[1][2][3][4] Evidence suggested that a shorter period of breastfeeding was a significant predictor for IRB. [1][2][3][4] The alteration in the composition of the intestinal microbiome in formula-fed infants has been associated with an increase of pro-inflammatory bacterial taxa and intestinal permeability, which could explain the clinical appearance of rectal bleeding. 5 Another finding of our study was that the empirical administration of antibiotics was significantly associated with IRB, although that was not found in a previous study by Maayan-Metzger.…”

Section: B R I E F R E P O R T Neonatal Isolated Rectal Bleeding: a Case-control Studymentioning

confidence: 99%

“…IRB has been attributed to an allergic reaction to cow's milk protein, 2,3 whereas ‘haemorrhagic or ecchymotic colitis’, a self‐limited phenomenon with possible involvement of allergic mechanisms, has been reported 4 . In view of the paucity of existing evidence, we aimed to determine the risk factors and outcomes of otherwise asymptomatic infants with IRB.…”

Section: Variables Cases (N=71) Controls (N=281) Pmentioning

confidence: 99%

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Neonatal isolated rectal bleeding: A case‐control study

et al. 2021

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Section: Variables Cases (N=71) Controls (N=281) Psupporting

confidence: 93%

Section: B R I E F R E P O R T Neonatal Isolated Rectal Bleeding: a Case-control Studymentioning

confidence: 99%

Section: B R I E F R E P O R T Neonatal Isolated Rectal Bleeding: a Case-control Studymentioning

confidence: 99%

Section: Variables Cases (N=71) Controls (N=281) Pmentioning

confidence: 99%

See 2 more Smart Citations

Neonatal isolated rectal bleeding: A case‐control study

et al. 2021

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The Incidence and Relevance of Hematochezia in the Interstage Congenital Heart Population

Strohacker,

Cutler,

et al. 2024

Pediatr Cardiol

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BackgroundNecrotizing enterocolitis (NEC) increases morbidity and mortality for infants with single ventricle heart disease (SVHD). While hematochezia often proceeds NEC not all hematochezia progresses to NEC. We aimed to examine the incidence, risk-factors, and outcomes associated with hematochezia and NEC for infants with SVHD. MethodsA single-center cohort study including SVHD patients requiring Stage I palliation from 12/2010-12/2015 was performed. Demographic, clinical, and outcome measures during the interstage period were abstracted from medical records. We de ned hematochezia as blood in the stool without alternative etiology and NEC as systemic or intestinal signs concurrent with hematochezia and/or the presence of radiographic pneumatosis. Clinical characteristics and outcome measures were compared between patients with/without hematochezia and with/without NEC. ResultsOf 135 patients, 59(44%) had hematochezia and 20(15%) developed NEC. Demographic and operative factors were similar between patients with and without hematochezia. Patients with NEC were more often premature (15% vs 0%, p = 0.04), have lower birth weight (3.0 ± 0.6 vs 3.3 ± 0.5 kg, p = 0.03), longer cardiopulmonary bypass time (median 131 vs. 90 minutes, p = 0.02) and more often underwent unplanned cardiac catheterization (20% vs 3%, p = 0.04). Patients with hematochezia had more line days (p < .0001) and longer post-Stage-I length of stay (p < .0001) than those without hematochezia, and those with NEC had more line days than those without NEC (p = 0.02). ConclusionsHematochezia is frequent following Stage-I palliation, however only one third of these patients develop NEC. Non-NEC Hematochezia is associated with a similar increase in line and hospital days. Further research is needed to identify methods to avoid over treatment.

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The Incidence and Relevance of Hematochezia in the Interstage Congenital Heart Population

Strohacker,

Cutler,

et al. 2023

Preprint

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Background Necrotizing enterocolitis (NEC) increases morbidity and mortality for infants with single ventricle heart disease (SVHD). While hematochezia often proceeds NEC not all hematochezia progresses to NEC. We aimed to examine the incidence, risk-factors, and outcomes associated with hematochezia and NEC for infants with SVHD.Methods A single-center cohort study including SVHD patients requiring Stage I palliation from 12/2010-12/2015 was performed. Demographic, clinical, and outcome measures during the interstage period were abstracted from medical records. We defined hematochezia as blood in the stool without alternative etiology and NEC as systemic or intestinal signs concurrent with hematochezia and/or the presence of radiographic pneumatosis. Clinical characteristics and outcome measures were compared between patients with/without hematochezia and with/without NEC.Results Of 135 patients, 59(44%) had hematochezia and 20(15%) developed NEC. Demographic and operative factors were similar between patients with and without hematochezia. Patients with NEC were more often premature (15% vs 0%, p = 0.04), have lower birth weight (3.0 ± 0.6 vs 3.3 ± 0.5 kg, p = 0.03), longer cardiopulmonary bypass time (median 131 vs. 90 minutes, p = 0.02) and more often underwent unplanned cardiac catheterization (20% vs 3%, p = 0.04). Patients with hematochezia had more line days (p < .0001) and longer post-Stage-I length of stay (p < .0001) than those without hematochezia, and those with NEC had more line days than those without NEC (p = 0.02).Conclusions Hematochezia is frequent following Stage-I palliation, however only one third of these patients develop NEC. Non-NEC Hematochezia is associated with a similar increase in line and hospital days. Further research is needed to identify methods to avoid over treatment.

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Neonatal isolated rectal bleeding and the risk of hypersensitivity syndromes

Abstract: An IRB event in the neonatal period does not increase the risk of developing hypersensitivity syndromes or food allergies during childhood.

Cited by 3 publications

References 16 publications

Neonatal isolated rectal bleeding: A case‐control study

Neonatal isolated rectal bleeding: A case‐control study

The Incidence and Relevance of Hematochezia in the Interstage Congenital Heart Population

The Incidence and Relevance of Hematochezia in the Interstage Congenital Heart Population

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