Microarc oxidation surface of titanium implants promote osteogenic differentiation by activating ERK1/2-miR-1827-Osterix

Liu, Liu; Zeng, Da; Chen, Yanwen; Zhou, Jiacheng; Liao, Ying; Shu, Bin

doi:10.1007/s11626-020-00444-7

Cited by 8 publications

(7 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They suppress osteogenic differentiation by decreasing Osx expression directly. Recently, Liu et al (2020) have certified that Osx serves as the direct target of miR-1827 and the inhibitive effect on osteogenic differentiation of miR-1827 amplification was reversed by Osx overexpression. In addition to this, some miRNAs indirectly regulated the expression of Osx via other genes.…”

Section: Mirnas Participate In Epigenetic Regulation Of Osx During Osteogenic Differentiationmentioning

confidence: 99%

Recent Advances of Osterix Transcription Factor in Osteoblast Differentiation and Bone Formation

Liu

Wang

et al. 2020

Front. Cell Dev. Biol.

131

View full text Add to dashboard Cite

With increasing life expectations, more and more patients suffer from fractures either induced by intensive sports or other bone-related diseases. The balance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption is the basis for maintaining bone health. Osterix (Osx) has long been known to be an essential transcription factor for the osteoblast differentiation and bone mineralization. Emerging evidence suggests that Osx not only plays an important role in intramembranous bone formation, but also affects endochondral ossification by participating in the terminal cartilage differentiation. Given its essentiality in skeletal development and bone formation, Osx has become a new research hotspot in recent years. In this review, we focus on the progress of Osx’s function and its regulation in osteoblast differentiation and bone mass. And the potential role of Osx in developing new therapeutic strategies for osteolytic diseases was discussed.

show abstract

Section: Mirnas Participate In Epigenetic Regulation Of Osx During Osteogenic Differentiationmentioning

confidence: 99%

Recent Advances of Osterix Transcription Factor in Osteoblast Differentiation and Bone Formation

Liu

Wang

et al. 2020

Front. Cell Dev. Biol.

131

View full text Add to dashboard Cite

show abstract

“…Simultaneously, RUNX2 is one of the downstream genes that can be regulated by the ERK1/2 signaling pathway [39,40]. Relevant studies have also demonstrated that ERK1/2 has a positive effect on the odonto/osteogenic differentiation of MSCs [41][42][43]. However, some studies have shown that the osteogenic activity of cells was enhanced after inhibiting the activity of ERK1/2 [44,45].…”

Section: Discussionmentioning

confidence: 99%

LIM Mineralization Protein-1 Enhances the Committed Differentiation of Dental Pulp Stem Cells through the ERK1/2 and p38 MAPK Pathways and BMP Signaling

Mu¹,

Chen²,

Bi³

et al. 2022

Int. J. Med. Sci.

View full text Add to dashboard Cite

Tissue regeneration is the preferred treatment for dentin and bone tissue defects. Dental pulp stem cells (DPSCs) have been extensively studied for their use in tissue regeneration, including the regeneration of dentin and bone tissue. LIM mineralization protein-1 (LMP-1) is an intracellular non-secretory protein that plays a positive regulatory role in the mineralization process. In this study, an LMP-1-induced DPSCs model was used to explore the effect of LMP-1 on the proliferation and odonto/osteogenic differentiation of DPSCs, as well as the underlying mechanisms. As indicated by the cell counting kit-8 assay, the results showed that LMP-1 did not affect the proliferation of DPSCs. Overexpression of LMP-1 significantly promoted the committed differentiation of DPSCs and vice versa, as shown by alkaline phosphatase activity assay, alizarin red staining, western blot assay, quantitative real-time polymerase chain reaction assay, and in vivo mineralized tissue formation assay. Furthermore, inhibiting the activation of the extracellular signal-regulated kinase 1/2 (ERK1/2), p38 mitogen-activated protein kinase (MAPK), and c-Jun N-terminal kinase (JNK) pathways using specific pathway inhibitors showed that the ERK1/2 and p38 MAPK pathways attenuated the differentiation of DPSCs. Besides, the expression of BMP signaling pathway components were also determined, which suggested that LMP-1 could activate BMP-2/Smad1/5 signaling pathway. Our results not only indicated the underlying mechanism of LMP-1 treated DPSCs but also provided valuable insight into therapeutic strategies in regenerative medicine.

show abstract

“…However, for the issue of in vivo toxicity, we suggest that some in vivo biosafety evaluations such as element concentration determination in serum and organs, blood parameter estimation, renal and liver function tests, and histological analysis of organs need to be conducted, which are often neglected in many studies on element-incorporated PEO coatings. As we can see, research in the PEO field at the mechanism level is very lacking, 66,211 and long-term study in vivo to verify the long-term stability is relatively weak. In another popular area, osteoimmunology, which plays an important role in osteogenesis, more comprehensive studies on PEO coatings containing inorganic elements are yet to be conducted.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Incorporation of inorganic elements onto titanium-based implant surfaces by one-step plasma electrolytic oxidation: an efficient method to enhance osteogenesis

et al. 2022

View full text Add to dashboard Cite

show abstract

Microarc oxidation surface of titanium implants promote osteogenic differentiation by activating ERK1/2-miR-1827-Osterix

Cited by 8 publications

References 37 publications

Recent Advances of Osterix Transcription Factor in Osteoblast Differentiation and Bone Formation

Recent Advances of Osterix Transcription Factor in Osteoblast Differentiation and Bone Formation

LIM Mineralization Protein-1 Enhances the Committed Differentiation of Dental Pulp Stem Cells through the ERK1/2 and p38 MAPK Pathways and BMP Signaling

Incorporation of inorganic elements onto titanium-based implant surfaces by one-step plasma electrolytic oxidation: an efficient method to enhance osteogenesis

Contact Info

Product

Resources

About