Microalbuminuria among Newly Diagnosed Diabetic Patients at Mulago National Referral Hospital in Uganda: A Cross Sectional Study

Martín, Miguel; Mutebi, Edrisa; Ssinabulya, Isaac; Kizito, Samuel; Mulindwa, Frank; Kiiza, Mondo Charles

doi:10.23937/2572-4010.1510021

Cited by 5 publications

(5 citation statements)

References 27 publications

(47 reference statements)

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“…69 According to the current study, the overall pooled prevalence of MAU among diabetes patients in Africa was 37.11% (95% CI: 31.27-42.95). This finding indicated that a significant proportion 40 37.12 31.15-43.09 Muse et al (2020) 41 36.75 30.83-42.67 Ogiator et al (2020) 42 37.17 31.18-43.16 Ufuoma et al (2016) 43 36.37 30.66-42.09 Halliru et al (2016) 44 37.22 31.22-43.22 Erasmus et al (1992) 45 36.63 30.74-42.52 Bissong et al (2017) 46 37.20 31.21-43.18 Efundem et al (2017) 47 37.87 31.95-43.79 Rahamtalla et al (2012) 48 36.91 30.97-42.85 Lutale et al (2007) 49 37.92 32.03-43.82 Lutale et al (2007) 49 37.98 32.25-43.71 Ghosh et al (2012) 50 37.39 31.35-43.43 Kantarama et al (2021) 51 36.27 30.53-42.0 Martin et al (2018) 52 36.84 30.89-42.79 Martin et al (2018) 52 36.64 30.74-42.55 Kiconco et al (2019) 53 37.59 31.56-43.62 Lubwama et al (2022) 54 37.88 31.97-43.79 Kalk et al (2010) 55 37.04 31.08-43.0 Molefe et al (2018) 56 36.87 30.89-42.85 Ramaphane et al (2021) 57 37.41 31.39-43.44 Fetni et al (2021) 58 37.23 31.14-43.32 Fetni et al (2021) 58 37.03 31.09-42.98 Eghan et al (2007) 59 36.93 30.96-42.90 Amolo P (2010) 60 38.09 This pooled prevalence of MAU among type 2 diabetes patients is comparable to the findings (39%) of a global crosssectional study on type 2 diabetes patients conducted in 33 countries. 70 A similar result of 35.1% (12.3-74.5%) was reported in large, multiple international cohort studies including >3 million participants.…”

Section: Discussionmentioning

confidence: 99%

“…For analysis purposes, studies done by Rahlenbeck et al, Martin et al, Lutale et al, and Fetni et al were extracted twice because they reported the prevalence of MAU separately for type 1 and type 2 DM. The studies were conducted in 14 different countries, including Ethiopia (2 studies), 40,41 Nigeria (6 studies), [42][43][44][45]66,67 Cameroon (3 studies), 46,47,64 Sudan (2 studies), 48,65 Tanzania (3 studies), [49][50][51] Uganda (2 studies), [52][53][54] South Africa (1 study), 55 Botswana (2 studies), 56,57 Algeria (1 study), 58 Ghana (1 study), 59 Kenya (1 study), 60 Egypt (1 study), 61 Senegal (1 study), 62 and Zambia (2 studies) 39,63 (Table 1).…”

Section: Overview Of Included Studiesmentioning

confidence: 99%

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Prevalence of Microalbuminuria Among Diabetes Patients in Africa: A Systematic Review and Meta-Analysis

Mohammed¹,

Alemayehu²,

Bisetegn³

et al. 2023

DMSO

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Background Microalbuminuria (MAU) is considered the earliest sign of diabetic nephropathy among diabetes patients. In order to effectively manage diabetic nephropathy and its consequences early, detection of microalbuminuria as soon as possible, especially for diabetes patients, is critical. Therefore, the present study aimed to determine the pooled prevalence of microalbuminuria among diabetes patients in Africa. Methods Electronic databases such as Google Scholar, PubMed, African Journals Online, Web of Science, Cochrane Library, EMBASE, and ResearchGate were searched for articles and grey literature. The STATA version 14 software was used to conduct the meta-analysis. I 2 and Cochran’s Q test were employed to assess the presence of heterogeneity between studies. Due to the presence of heterogeneity, a random effect model was used. The publication bias was assessed using the symmetry of the funnel plot and Egger’s test statistics. Moreover, subgroup analysis, trim and fill analysis, and sensitivity analysis were also done. Results The overall pooled prevalence of microalbuminuria among diabetes patients in Africa was 37.11% (95% CI 31.27–42.95). Substantial heterogeneity was observed between studies, with I 2 values of 94.7%. Moreover, this meta-analysis showed that the pooled estimate of microalbuminuria among type 1 and type 2 diabetes patients was 35.34% (95% CI: 23.89–46.80, I 2 =94.2), and 40.24% (95% CI: 32.0–48.47, I 2 =94.9) respectively. MAU, on the other hand, was more common in people with diabetes for more than 5 years 38.73% (95% CI: 29.34–48.13) than in people with diabetes for less than 5 years 31.48% (95% CI: 18.73–44.23). Conclusion This systematic review and meta-analysis found a high prevalence of microalbuminuria among diabetes patients. As a result, early detection of microalbuminuria is critical for preventing and treating microvascular complications such as diabetic nephropathy and the onset of end-stage renal disease.

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Section: Discussionmentioning

confidence: 99%

Section: Overview Of Included Studiesmentioning

confidence: 99%

Prevalence of Microalbuminuria Among Diabetes Patients in Africa: A Systematic Review and Meta-Analysis

Mohammed¹,

Alemayehu²,

Bisetegn³

et al. 2023

DMSO

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“…Martin et al reported over 51% of their newly detected diabetic patients were males with mean age of 46 years in Uganda while Sosale et al reported over two-thirds being males in India. 19,20 Aboelnasr et al from Egypt reported two-thirds of newly detected diabetic patients being females and mean age was over 48 years. 21 Bansal et al reported female predominance of newly detected diabetic patients in another Indian report with mean age of nearly 50 years.…”

Section: Discussionmentioning

confidence: 99%

Diabetic nephropathy and its risk factors among patients with diabetes mellitus-an observational study

Saha¹,

Saifuddin

Moni³

et al. 2023

Int J Res Med Sci

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Background: Diabetic nephropathy (DN) is frequently associated with T2DM and the leading cause of chronic kidney disease and end-stage renal disease. Diabetic nephropathy is one of the three classic micro-vascular complications of diabetes mellitus (DM), traditionally described among patients with long duration and poor control of DM. The aim of this study was to identify and evaluate the risk factors for diabetic nephropathy among patients with DM. Methods: This was a retrospective observational study and was conducted in the department of medicine, LABAID specialized hospital, Dhaka, Bangladesh during the period from March 2022 to March 2023. We included 345 patients with DM and diabetic nephropathy in our study. Results: In our study the mean age was 43.1±9.3 years and majority (57%) of patients were female. Among all patients 48% had diabetes for less than 8 years. Majority (72%) patients got nephropathy because of elevated glucose levels. We found other risk factors like advanced age (37.39%), smoking (27.83%), obesity (61.16%), elevated blood pressure (53.33%), dyslipidemia (20%), longer duration of diabetes (47.25%), family history of DM and DN (21.45% and 24.35%) and retinopathy (25.80%). Conclusions: In our study, we found advanced age, high glucose level, high blood pressure, obesity, long duration of DM, family history of DM and diabetic nephropathy, smoking, dyslipidemia and concomitant diabetic retinopathy were significant risk factors for diabetic nephropathy among selected diagnosed diabetic patients.

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“…The number of past episodes of DKA in each of the subjects was recorded. Microalbuminuria is defined as albumin to creatinine ratio (ACR) between 30 and 299 mg/g (7) However, it was assessed on the first morning using 5 mL of spot urine sample, collected in a clean plastic container. The ACR ratio was calculated in mg albumin/gm of creatinine.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of Microalbuminuria and Glycosylated Hemoglobin in the Assessment of Diabetes Control in Children with Type 1 Diabetes Mellitus Hospitalized with Diabetic Ketoacidosis

et al. 2021

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Background: Microalbuminuria is thought to be an early predictor of impending diabetic nephropathy, while glycosylated hemoglobin (HbA1c) is a biochemical marker of long-term glycemic control in children with type 1 diabetes mellitus (T1DM). Objectives: The study aimed to evaluate the prevalence of microalbuminuria and its association with HbA1c on admission and duration of diabetes. Also, changes in HbA1c level on admission and three months after admission were studied to assess diabetes control in children with T1DM. Methods: This prospective study was conducted among 38 children (< 18 years) diagnosed with TIDM presenting with clinical signs, symptoms, and biochemical parameters of DKA. The presence of microalbuminuria, HbA1c level, and the number of past episodes of DKA were recorded. HbA1c level was again estimated after three months. The resultant data was tabulated and analyzed statistically (P < 0.05). Results: Microalbuminuria and poor HbA1c control were observed in 18% and 60% of the sample population, respectively. A significant association was found between HbA1c > 9% (P = 0.032) and the duration of diabetes > 4 years (P = 0.032) and microalbuminuria. Significant improvement in glycemic control was noted from the time of admission to three months after admission (9.76 ± 2.77 vs. 7.75 ± 1.28; P = 0.00012). A significant difference was observed between past DKA episodes according to HbA1c control (P < 0.001). Conclusions: Microalbuminuria assessment is needed in T1DM children, especially those with HbA1c > 9% and duration of diabetes > four years, to evaluate diabetic nephropathy. Good glycemic control can be achieved with effective insulin therapy accompanied by appropriate counseling and regular follow-up.

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Microalbuminuria among Newly Diagnosed Diabetic Patients at Mulago National Referral Hospital in Uganda: A Cross Sectional Study

Cited by 5 publications

References 27 publications

Prevalence of Microalbuminuria Among Diabetes Patients in Africa: A Systematic Review and Meta-Analysis

Prevalence of Microalbuminuria Among Diabetes Patients in Africa: A Systematic Review and Meta-Analysis

Diabetic nephropathy and its risk factors among patients with diabetes mellitus-an observational study

Evaluation of Microalbuminuria and Glycosylated Hemoglobin in the Assessment of Diabetes Control in Children with Type 1 Diabetes Mellitus Hospitalized with Diabetic Ketoacidosis

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