Micro Total Analysis Systems: Microfluidic Aspects, Integration Concept and Applications

Abstract

In this contribution three aspects of miniaturized total analysis systems (mTAS) are described and discussed in detail. First, an overview of microfabricated components for fluid handling is given. A description of the importance of sampling-and fluid-handling techniques is followed by details of microvalves, micropumps and micro flowchannels. Secondly, the problems associated with system integration are discussed. As a solution for the realization of microfluidic-and micro analysis systems, the concept of a planar mixed circuit board (MCB) as a platform for the integration of different components is described. In addition, the design, modeling and simulation, and realization of several components in the form of standard modules for integration on a MCB is described. As an illustration of the potential of this approach, the realization of a mTAS demonstrator for the optical detection of the pH change of a pH indicator, is presented. Finally, a number of different applications of mTAS are described, such as on-line process monitoring, environmental monitoring, biomedical and space applications and DNA-analysis.

Prototype of calorimetric flow microsensor

“…With the use of previously formed labels a photolithography process is carried out in order to obtain the topology of the plate's surface as a whole, in particular lines for scribing and membranes etching masks are formed. In the membrane area on the non-planar side of the plate the monocrystalline silicon is etched to [10][11][12][13][14][15][16][17][18][19][20] thickness, which is sufficient to provide mechanical strength to carry out further operations.…”

“…Thermal flow microsensors are used in Micro Total Analysis S which recently has been significantly developed [10].…”

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

“…[194] Hence, it is economically beneficial in processing or testing where minimal amounts of precious reagents are available. [195] Particularly when used for informatics rather than for product synthesis, MF reactors consume far less reagent than bulk systems to gather the same (and in most cases more) chemical information.…”

Liquid Aspiration and Dispensing Based on an Expanding PDMS Composite

“…In early developments, materials well known from the conventional semiconductor industry, such as silicon and glass, were used [4]- [6]. However, the complexity of devices based on these materials and their associated fabrication techniques make integration into such systems difficult and costly.…”