Micro/Nano Electrode Array Sensors: Advances in Fabrication and Emerging Applications in Bioanalysis

Liu, Yang; Li, Xiuting; Chen, Jie; Yuan, Chonglin

doi:10.3389/fchem.2020.573865

Cited by 31 publications

(16 citation statements)

References 111 publications

(141 reference statements)

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“…reported a highdensity vertical Si nanowire array (∼62500 tips/mm 2 ) with independent electrical addressability and high spatial resolution. These arrays were utilized to record electrophysiological signals from primary neurons of rat/mouse and hiPSC-derived neurons without cell damage [82]. However, in terms of OECT-based arrays, the highest density is limited at about 950/mm 2 [2], which is far too low compared to these in MEA.…”

Section: Integration Densitymentioning

confidence: 99%

Integrated Sensing Arrays Based on Organic Electrochemical Transistors

Wen

Huang

et al. 2022

IEEE Open J. Nanotechnol.

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Organic electrochemical transistors (OECTs), as one of the most promising sensing techniques, have shown various advantages compared to traditional means, which include ultra-high sensitivity, low driving voltage, and excellent biocompatibility for different bioelectrical and biochemical sensing. Moreover, to fully unleash the potential of OECT sensors, integrated sensing systems, especially OECT-based sensing arrays, are widely investigated due to spatiotemporal resolution, mechanical flexibility, high optical transparency, low power dissipation, and ease of fabrication. These advantages are attributed to the unique working mechanism of OECT, novel mixed ionic-electronic (semi)conductors, adaptable device geometry/structure, etc. In this review, advances in OECT-based sensing systems are systematically summarized, with a focus on the OECT-based sensing array. Furthermore, perspectives, concerning stability, cut-off frequency, integrating density, and power dissipation, are discussed based on recent studies on OECTs and their relevant sensor arrays. Last, a summary and an outlook of this field are provided.

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Section: Integration Densitymentioning

confidence: 99%

Integrated Sensing Arrays Based on Organic Electrochemical Transistors

Wen

Huang

et al. 2022

IEEE Open J. Nanotechnol.

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“…Nanoscale 3D printing provides inexpensive and rapid custom design prototyping without the constraints of traditional manufacturing [ 286 ]. More details about 3D printing for biomedical and electronic devices can be found in the reviews by L. Line et al [ 290 ], by K. Muldoon et al [ 291 ] and Y. Liu et al [ 292 ].…”

Section: Modern Advances In the Field Of In Vivo Penetrating Microele...mentioning

confidence: 99%

In Vivo Penetrating Microelectrodes for Brain Electrophysiology

Ерофеев

Antifeev²,

Bolshakova³

et al. 2022

Sensors

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In recent decades, microelectrodes have been widely used in neuroscience to understand the mechanisms behind brain functions, as well as the relationship between neural activity and behavior, perception and cognition. However, the recording of neuronal activity over a long period of time is limited for various reasons. In this review, we briefly consider the types of penetrating chronic microelectrodes, as well as the conductive and insulating materials for microelectrode manufacturing. Additionally, we consider the effects of penetrating microelectrode implantation on brain tissue. In conclusion, we review recent advances in the field of in vivo microelectrodes.

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“…Decreasing the surface area of working electrode to micro/nano scale offers several advantages on the electroanalytical performance of the sensor such as enhanced signal-to-noise ratio, increased sensitivity, and small sample volume (Juska et al, 2019;Tarasov et al, 2016;Wasiewska et al, 2021). The double layer around the micro/nano electrode has a lower capacitance and smaller time constant that allow the signal to be measured more rapidly and with less destruction to the sensor (Liu et al, 2020). As the electrode dimensions are smaller than the diffusion layer thickness, the mass transport increases and therefore its sensitivity also increases (Liu et al, 2020).…”

Section: Gold Electrodesmentioning

confidence: 99%

“…The double layer around the micro/nano electrode has a lower capacitance and smaller time constant that allow the signal to be measured more rapidly and with less destruction to the sensor (Liu et al, 2020). As the electrode dimensions are smaller than the diffusion layer thickness, the mass transport increases and therefore its sensitivity also increases (Liu et al, 2020). Smaller size electrodes can be used to manufacture high-density multiplexed devices which may open up the way for commercialisation (Wahl et al, 2013).…”

Section: Gold Electrodesmentioning

confidence: 99%

Electrochemical nucleic acid-based sensors for detection of E. coli and Shiga toxin-producing E. coli (STEC) – Review of the recent developments

Wasiewska

Seymour

Juska

et al. 2022

Preprint

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Escherichia coli (E. coli) are a group of bacteria, which are a natural part of the intestinal flora of warm-blooded animals, including humans. Most E. coli are non-pathogenic and are essential for the normal function of a healthy intestine, however, certain types such as Shiga toxin-producing E. coli (STEC) is a foodborne pathogen that can cause a life-threatening illness. Development of point-of-care (POC), rapid detection devices for E. coli have high importance from a food safety point of view. The most suitable way to distinguish between generic E. coli and STEC is by using nucleic acid-based detection, focusing on the virulence factors. Electrochemical sensors based on nucleic acid recognition have attracted much attention in recent years for use in pathogenic bacteria detection. This review has summarised nucleic acid-based sensors for the detection of generic E. coli and STEC since 2015. First, the sequences of the genes used as recognition probes are discussed and compared to the most recent research regarding the specific detection of general E. coli and STEC. Subsequently, the collected literature regarding nucleic acid-based sensors was described and discussed. The traditional sensors were divided into four categories such as gold, ITO, carbon-based electrodes, and those using magnetic particles. Finally, we summarised the future trends in nucleic acid-based sensor development for E. coli and STEC including some examples of fully integrated devices

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Micro/Nano Electrode Array Sensors: Advances in Fabrication and Emerging Applications in Bioanalysis

Cited by 31 publications

References 111 publications

Integrated Sensing Arrays Based on Organic Electrochemical Transistors

Integrated Sensing Arrays Based on Organic Electrochemical Transistors

In Vivo Penetrating Microelectrodes for Brain Electrophysiology

Electrochemical nucleic acid-based sensors for detection of E. coli and Shiga toxin-producing E. coli (STEC) – Review of the recent developments

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