In Vivo Penetrating Microelectrodes for Brain Electrophysiology

Abstract

In recent decades, microelectrodes have been widely used in neuroscience to understand the mechanisms behind brain functions, as well as the relationship between neural activity and behavior, perception and cognition. However, the recording of neuronal activity over a long period of time is limited for various reasons. In this review, we briefly consider the types of penetrating chronic microelectrodes, as well as the conductive and insulating materials for microelectrode manufacturing. Additionally, we consider the effects of penetrating microelectrode implantation on brain tissue. In conclusion, we review recent advances in the field of in vivo microelectrodes.

Advances in the Electrophysiological Recordings of Long-Term Potentiation

“…The method can provide more information than non-penetrating microelectrodes. It has been used short-term and documented in rodent studies with low levels of tissue damage [ 69 ]. The most obvious advantage of in vivo extracellular recording is that it cannot only simultaneously record the electrical activity of many neurons in multiple brain regions but also allow the use of population enhancement data to detect the excitatory synaptic action of the population when the animal is in a more natural state.…”