Advances in the Electrophysiological Recordings of Long-Term Potentiation

Jiang, Feixu; Bello, Stephen Temitayo; Gao, Qianqian; Lai, Yuanying; Li, Xiao; He, Ling

doi:10.3390/ijms24087134

Cited by 5 publications

(3 citation statements)

References 182 publications

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“…Simultaneously, examining synaptic plasticity, which encompasses the structural and functional changes in synapses responsible for learning and memory, is essential [17,25]. This involves assessing processes like LTP and LTD through electrophysiological measurements and imaging studies [61]. These investigations could reveal how shifts in GABAergic signalling affect synaptic strength and structure, influencing cognitive processes.…”

Section: Discussionmentioning

confidence: 99%

Increasing Ambient GABA Levels in the Hippocampus to Improve Cognition in a Mouse Model of Schizophrenia: A Research Protocol

Miliukov

2024

URNCST Journal

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Introduction: Schizophrenia is a complex psychiatric disorder characterized by cognitive, positive, and negative symptoms, with cognitive impairments significantly affecting learning, memory, and executive functions. The hippocampus, particularly the CA1 region, is a critical area of interest due to its role in learning and memory and its dysfunction in schizophrenia. This protocol explores the effects of increasing ambient Gamma-Aminobutyric Acid (GABA) levels in the CA1 region on cognitive functions in a Methylazoxymethanol Acetate (MAM) model of schizophrenia. Methods: Utilizing a two-by-two factorial design, male Sprague-Dawley rats undergo either a sham or MAM treatment, followed by a control or GABA modulation intervention. The study will employ GABA transporter inhibitor Tiagabine to increase ambient GABA levels and assess its impact on neuronal excitability and cognitive function. Behavioural assessments will include the Morris water maze and the Attentional set-shifting test to evaluate spatial memory and cognitive flexibility. Histological examinations and electrophysiological measurements will provide insights into structural and functional changes in the hippocampus. Results: The results are expected to demonstrate neurodevelopmental disruptions in MAM-treated offspring and improvements in cognitive performance following GABA modulation. Enhanced spatial memory and cognitive flexibility are anticipated in MAM-treated rats with GABA modulation, as evidenced by performance in the Morris water maze and Attentional set-shifting test. Electrophysiological recordings are likely to show increased tonic inhibition in the CA1 region. Discussion: This study aims to extend the understanding of tonic inhibition in schizophrenia treatment. By focusing on ambient GABA modulation, the research could offer novel insights into therapeutic strategies for schizophrenia, especially in enhancing cognitive functions. However, the translational applicability of intracerebral administration of uptake inhibitors like Tiagabine poses a significant challenge, highlighting the need for future research in more clinically viable methods of GABA modulation. Conclusion: This study was designed to contribute to schizophrenia research, particularly in understanding cognitive impairments and developing potential therapeutic strategies targeting the GABAergic system. The proposed findings could pave the way for novel treatments, improving the quality of life for individuals with schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Increasing Ambient GABA Levels in the Hippocampus to Improve Cognition in a Mouse Model of Schizophrenia: A Research Protocol

Miliukov

2024

URNCST Journal

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“…Gene expression is not sufficient to report changes in synaptic plasticity. Therefore, future studies should implement more definitive techniques such as the use of electrophysiology [82] to investigate whether MR is improving cognition at the synaptic level via alterations in synaptic plasticity (i.e., long-term potentiation and long-term depression).…”

Section: Mr: Linking Cognitive Effects To Mechanismsmentioning

confidence: 99%

Effects of Dietary Methionine Restriction on Cognition in Mice

Lail,

Mabb,

Parent

et al. 2023

Nutrients

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Dietary restriction of the essential amino acid, methionine, has been shown to induce unique metabolic protection. The peripheral benefits of methionine restriction (MR) are well established and include improvements in metabolic, energy, inflammatory, and lifespan parameters in preclinical models. These benefits all occur despite MR increasing energy intake, making MR an attractive dietary intervention for the prevention or reversal of many metabolic and chronic conditions. New and emerging evidence suggests that MR also benefits the brain and promotes cognitive health. Despite widespread interest in MR over the past few decades, many findings are limited in scope, and gaps remain in our understanding of its comprehensive effects on the brain and cognition. This review details the current literature investigating the impact of MR on cognition in various mouse models, highlights some of the key mechanisms responsible for its cognitive benefits, and identifies gaps that should be addressed in MR research moving forward. Overall findings indicate that in animal models, MR is associated with protection against obesity-, age-, and Alzheimer’s disease-induced impairments in learning and memory that depend on different brain regions, including the prefrontal cortex, amygdala, and hippocampus. These benefits are likely mediated by increases in fibroblast growth factor 21, alterations in methionine metabolism pathways, reductions in neuroinflammation and central oxidative stress, and potentially alterations in the gut microbiome, mitochondrial function, and synaptic plasticity.

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“…Understanding neuronal mechanisms behind LTP is critical for understanding memory, learning, and impairments during neurodegenerative diseases. Despite the recent advancement in neuroscience, we are still limited by the experimental design and techniques for exploring the mechanisms and pathways involved in LTP [9]. This increases the need for theoretical and modeling studies revealing and explaining the possible mechanisms of LTP.…”

Section: Introductionmentioning

confidence: 99%

Hysteresis and bistability in synaptic transmission modeled as a chain of biochemical reactions with a positive feedback

Katauskis,

Ivanauskas,

Alaburda

2024

NAMC

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In this paper, we employ computational analysis to investigate the long-term potentiation (LTP) and memory formation in synapses between neurons. We use a mathematical model describing the synaptic transmission as a signal transduction pathway with a positive feedback loop formed by diffusion of nitric oxide (NO) to the presynaptic site. We found that the model of synaptic transmission exhibits a hysteresis-like behavior, where the strength of synaptic transmission depends not just on instantaneous interstimulus intervals, but also on the history of activity. The switching between resting and memory states can be induced by physiologically relevant and moderate (less than 50%) changes in the duration of interstimulus intervals.

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Advances in the Electrophysiological Recordings of Long-Term Potentiation

Cited by 5 publications

References 182 publications

Increasing Ambient GABA Levels in the Hippocampus to Improve Cognition in a Mouse Model of Schizophrenia: A Research Protocol

Increasing Ambient GABA Levels in the Hippocampus to Improve Cognition in a Mouse Model of Schizophrenia: A Research Protocol

Effects of Dietary Methionine Restriction on Cognition in Mice

Hysteresis and bistability in synaptic transmission modeled as a chain of biochemical reactions with a positive feedback

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