Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent

Samei,

doi:10.2147/ijn.s7881

Cited by 44 publications

(31 citation statements)

References 14 publications

(11 reference statements)

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“…Our in vitro test results were consistent with those of in vivo testing. Microcomputed tomography is effective and reproducible for monitoring tumor-associated bone destruction, 31,32 analyzing the three-dimensional structure of scaffolds, 33 measuring subtle differences in bone growth into three-dimensional scaffolds, and calculating new bone deposition around implants. 34,35 In this study, the percent of bone volume/tissue volume of regenerated bone in the marrow bonding to the implants was calculated, and three-dimensional images were constructed.…”

Section: Figure 10mentioning

confidence: 99%

Nano-TiO2/PEEK bioactive composite as a bone substitute material: in vitro and in vivo studies

Liu²,

Wei³

et al. 2012

IJN

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Background: Compared with titanium (Ti) and other metal implant materials, poly(ether-ether ketone) (PEEK) shows outstanding biomechanical properties. A number of studies have also reported attractive bioactivity for nano-TiO 2 (n-TiO 2 ). Methods: In this study, n-TiO 2 /PEEK nanocomposites were prepared, taking advantage of the unique properties of both PEEK polymer and n-TiO 2 . The in vitro and in vivo bioactivity of these nanocomposites was assessed against a PEEK polymer control. The effect of surface morphology or roughness on the bioactivity of the n-TiO 2 /PEEK nanocomposites was also studied. n-TiO 2 /PEEK was successfully fabricated and cut into disks for physical and chemical characterization and in vitro studies, and prepared as cylindrical implants for in vivo studies. Their presence on the surface and dispersion in the composites was observed and analyzed by scanning and transmission electron microscopy and X-ray photoelectron spectroscopy. Results: Bioactivity evaluation of the nanocomposites revealed that pseudopods of osteoblasts preferred to anchor at areas where n-TiO 2 was present on the surface. In a cell attachment test, smooth PEEK showed the lowest optical density value (0.56 ± 0.07) while rough n-TiO 2 /PEEK exhibited the highest optical density value (1.21 ± 0.34, P , 0.05). In in vivo studies, the percent bone volume value of n-TiO 2 /PEEK was approximately twice as large as that of PEEK (P , 0.05). Vivid three-dimensional and histologic images of the newly generated bone on the implants further supported our test results. Conclusion: Our study demonstrates that n-TiO 2 significantly improves the bioactivity of PEEK, especially if it has a rough composite surface. A n-TiO 2 /PEEK composite with a rough surface could be a novel alternative implant material for orthopedic and dental applications.

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Section: Figure 10mentioning

confidence: 99%

Nano-TiO2/PEEK bioactive composite as a bone substitute material: in vitro and in vivo studies

Liu²,

Wei³

et al. 2012

IJN

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“…For example, Samei et al have reported the use of a long-circulating liposomal system encapsulating traditional iodinated contrast agent for micro-CT imaging of rats implanted with R3230AC mammary carcinoma [75]. …”

Section: Introductionmentioning

confidence: 99%

Nanotechnology-mediated targeting of tumor angiogenesis

2011

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Angiogenesis is disregulated in many diseased states, most notably in cancer. An emerging strategy for the development of therapies targeting tumor-associated angiogenesis is to harness the potential of nanotechnology to improve the pharmacology of chemotherapeutics, including anti-angiogenic agents. Nanoparticles confer several advantages over that of free drugs, including their capability to carry high payloads of therapeutic agents, confer increased half-life and reduced toxicity to the drugs, and provide means for selective targeting of the tumor tissue and vasculature. The plethora of nanovectors available, in addition to the various methods available to combine them with anti-angiogenic drugs, allows researchers to fine-tune the pharmacological profile of the drugs ad infinitum. Use of nanovectors has also opened up novel avenues for non-invasive imaging of tumor angiogenesis. Herein, we review the types of nanovector and therapeutic/diagnostic agent combinations used in targeting tumor angiogenesis.

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“…46,47 Molecular imaging targeting vascular endothelial cells can offer this in a noninvasive way. 46,[48][49][50] Due to a relatively good spatial resolution, good soft-tissue contrast, absence of ionizing radiation, and limited side effects, MRI …”

Section: Discussionmentioning

confidence: 99%

Targeting T<sub>1</sub> and T<sub>2</sub> dual modality enhanced magnetic resonance imaging of tumor vascular endothelial cells based on peptides-conjugated manganese ferrite nanomicelles

Gong

Yang

Zhang

et al. 2016

IJN

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Tumor angiogenesis plays very important roles for tumorigenesis, tumor development, metastasis, and prognosis. Targeting T 1 /T 2 dual modality magnetic resonance (MR) imaging of the tumor vascular endothelial cells (TVECs) with MR molecular probes can greatly improve diagnostic sensitivity and specificity, as well as helping to make an early diagnosis of tumor at the preclinical stage. In this study, a new T 1 and T 2 dual modality nanoprobe was successfully fabricated. The prepared nanoprobe comprise peptides CL 1555, poly(ε-caprolactone)-block-poly(ethylene glycol) amphiphilic copolymer shell, and dozens of manganese ferrite (MnFe 2 O 4 ) nanoparticle core. The results showed that the hydrophobic MnFe 2 O 4 nanoparticles were of uniform spheroidal appearance and narrow size distribution. Due to the self-assembled nanomicelles structure, the prepared probes were of high relaxivity of 281.7 mM −1 s −1 , which was much higher than that of MnFe 2 O 4 nanoparticles (67.5 mM 1 s −1 ). After being grafted with the targeted CD105 peptide CL 1555, the nanomicelles can combine TVECs specifically and make the labeled TVECs dark in T 2 -weighted MR imaging. With the passage on, the Mn 2+ ions were released from MnFe 2 O 4 and the size decreased gradually, making the signal intensity of the second and third passage of labeled TVECs increased in T 1 -weighted MR imaging. Our results demonstrate that CL-poly(ethylene glycol)-MnFe 2 O 4 can conjugate TVECs and induce dark and bright contrast in MR imaging, and act as a novel molecular probe for T 1 - and T 2 -enhanced MR imaging of tumor angiogenesis.

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Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent

Cited by 44 publications

References 14 publications

Nano-TiO2/PEEK bioactive composite as a bone substitute material: in vitro and in vivo studies

Nano-TiO2/PEEK bioactive composite as a bone substitute material: in vitro and in vivo studies

Nanotechnology-mediated targeting of tumor angiogenesis

Targeting T<sub>1</sub> and T<sub>2</sub> dual modality enhanced magnetic resonance imaging of tumor vascular endothelial cells based on peptides-conjugated manganese ferrite nanomicelles

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