Nanotechnology-mediated targeting of tumor angiogenesis

Banerjee, Deboshri; Harfouche, Rania; Sengupta, Shiladitya

doi:10.1186/2045-824x-3-3

Cited by 92 publications

(71 citation statements)

References 101 publications

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“…Our findings have profound implications for targeting the endothelial-specific expression of β3-integrin to inhibit tumor angiogenesis, a strategy that is growing in popularity with the maturation of nanotechnology. 38 Consistent with our findings in β3-knockout animals, 10 the depletion of endothelial β3-integrin did not alter the structure of established tumor vessels (Online Figure IA and Online Figure VIA). Sprouting angiogenesis involves an initial increase in EC proliferation, migration, and tube formation, followed by maturation of vessels that includes the recruitment of supporting cells and the deposition of an intact basement.…”

Section: Discussionsupporting

confidence: 80%

Acute Depletion of Endothelial β3-Integrin Transiently Inhibits Tumor Growth and Angiogenesis in Mice

Steri

Ellison

Gontarczyk

et al. 2014

Circulation Research

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Rationale:The dramatic upregulation of αvβ3-integrin that occurs in the vasculature during tumor growth has long suggested that the endothelial expression of this molecule is an ideal target for antiangiogenic therapy to treat cancer. This discovery led to the development of small-molecule inhibitors directed against αvβ3-integrin that are currently in clinical trials. In 2002, we reported that β3-integrin−knockout mice exhibit enhanced tumor growth and angiogenesis. However, as β3-integrin is expressed by a wide variety of cells, endothelial cell-specific contributions to tumor angiogenesis are muddied by the use of a global knockout of β3-integrin function.Objective: Our aim was to examine the endothelial-specific contribution β3-integrin makes to tumor growth and angiogenesis. Methods and Results:We have crossed β3-integrin-floxed (β3-floxed) mice to 2 endothelial-specific Cre models and examined angiogenic responses in vivo, ex vivo, and in vitro. We show that acute depletion of endothelial β3-integrin inhibits tumor growth and angiogenesis preventatively, but not in already established tumors. However, the effects are transient, and long-term depletion of the molecule is ineffective. Furthermore, long-term depletion of the molecule correlates with many molecular changes, such as reduced levels of focal adhesion kinase expression and a misbalance in focal adhesion kinase phosphorylation, which may lead to a release from the inhibitory effects of decreased endothelial β3-integrin expression. Conclusions:

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Section: Discussionsupporting

confidence: 80%

Acute Depletion of Endothelial β3-Integrin Transiently Inhibits Tumor Growth and Angiogenesis in Mice

Steri

Ellison

Gontarczyk

et al. 2014

Circulation Research

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“…Such a modification increases the targeting potential of dendrimers toward cancer cells [70]. A combination of imaging modalities and several biocompatible and biodegradable dendrimers over the decade has been used to develop bio-imaging probes that have prolonged plasma half-lives, enhanced stability, reduced toxicity and improved target specificity.…”

Section: Molecular Imaging With Radiolabeled Dendrimersmentioning

confidence: 99%

Radiolabeled Dendrimers as Potential PET Agents for Molecular Imaging of Tumor Angiogenesis

Ghai¹,

Singh²,

Chopra³

et al. 2018

Dendrimers - Fundamentals and Applications

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Introduction: Angiogenesis is a normal physiological process that plays an imperative role during tumor development. We believe that the development of a non-invasive imaging technique targeting angiogenesis can provide a better understanding of this important process. Positron emission tomography (PET) -a highly sensitive imaging technique can offer accurate degree of disease quantification. The phenomenon of enhanced permeability and retention effect (EPR effect) is now becoming the gold standard in cancer targeting drug designing. Dendrimers have the ability to exhibit EPR effect for targeted therapeutic/drug delivery approach. Therefore, molecular imaging of tumor angiogenesis using radio-labeled dendrimers is expected to broaden the possibilities for drug development. Body:In the present chapter, the significance of performing conjugation chemistry of bifunctional chelators quality control parameters of the radiolabeled dendrimer conjugates in vitro stability, animal biodistribution, radiation dosimetry and molecular imaging of animal tumor model after injecting radiotracer have also been discussed in detail. Conclusion:Conjugation of the radio-metal complexes to larger molecules like dendrimers has created a new domain of research in the field of biomedical applications. Therefore, it has been proposed to develop new effective targeting moieties suitable for radiolabeling with PET tracers so as to perform molecular imaging studies.

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“…[1][2][3][4][5][6][7][8] Carbon nanotubes (CNTs), with their unique physical and chemical properties, hold great promise for drug delivery and cancer therapy. 9 The research mechanisms of selective tumor targeting with biofunctionalized CNTs are currently being intensely explored due to their impressive ability to convert near-infrared (NIR) laser radiation into heat.…”

Section: Introductionmentioning

confidence: 99%

Advances in cancer therapy through the use of carbon nanotube-mediated targeted hyperthermia

Iancu

Mocan²

2011

IJN

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Carbon nanotubes (CNTs) are emerging versatile tools in nanomedicine applications, particularly in the field of cancer targeting. Due to diverse surface chemistry and unique thermal properties, CNTs can act as strong optical absorbers in near infrared light where biological systems prove to be highly transparent. The process of laser-mediated ablation of cancer cells marked with biofunctionalized CNTs is frequently termed “nanophotothermolysis.” This paper illustrates the potential of engineered CNTs as laser-activated photothermal agents for the selective nanophotothermolysis of cancer cells.

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Nanotechnology-mediated targeting of tumor angiogenesis

Cited by 92 publications

References 101 publications

Acute Depletion of Endothelial β3-Integrin Transiently Inhibits Tumor Growth and Angiogenesis in Mice

Acute Depletion of Endothelial β3-Integrin Transiently Inhibits Tumor Growth and Angiogenesis in Mice

Radiolabeled Dendrimers as Potential PET Agents for Molecular Imaging of Tumor Angiogenesis

Advances in cancer therapy through the use of carbon nanotube-mediated targeted hyperthermia

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