Nano-TiO2/PEEK bioactive composite as a bone substitute material: in vitro and in vivo studies

Wu, Xiaomian; Liu, Xiaochen; Wei, Jie; Ma, Jian; Deng, Feng; Wei, Shicheng

doi:10.2147/ijn.s28101

Cited by 65 publications

(29 citation statements)

References 32 publications

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“…Previous studies have reported that PEEK material exhibits extremely limited osteoconductive properties, unlike titanium. Therefore, a significant amount of research has been conducted to increase the bioactivity of PEEK implants (25). Primary of these are studies of surface roughening.…”

Section: Peek Implantsmentioning

confidence: 99%

Areas for use of PEEK material in dentistry

et al. 2018

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Polyetheretherketone (PEEK) material is a polycyclic, aromatic, thermoplastic polymer that is semi-crystalline and has a linear structure. PEEK has good mechanical and electrical properties such as resistance to high temperature and resistance to hydrolysis. In addition, because of the property of high biocompatibility, use of PEEK has increased in orthopaedic and trauma cases. The most characteristic property of PEEK material is that it has a low elasticity modulus, close to that of bone. It has been suggested that stress-based problems could be reduced with this material due to the low elasticity modulus. In the light of this information, PEEK material could be considered as an alternative to conventional materials in the field of dentistry.

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Section: Peek Implantsmentioning

confidence: 99%

Areas for use of PEEK material in dentistry

et al. 2018

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“…Nowadays, alloy is used for its superior corrosion resistance, and different types of bearing surfaces are available 49,50 . Ti particles released from Ti bulk implant or composites was confirmed by studies, and it was inevitable to apply Ti as a biomaterial, considering its outstanding mechanical property 1,2,13,14,16,17,22 . However, little is known about the interaction existing in different materials 50 .…”

Section: Discussionmentioning

confidence: 96%

“…In particle disease, peri-implant osteolysis which is caused by wear particles remains the main complication for implant failure after the surgical [5][6][7][8] . Although the development of materials (Metal, Polyethylene, Polymethylmethacrylate, and Ceramic) undergone a marvelous evolution over the past half-century, yet none can be considered to be absolutely perfect [9][10][11][12][13] . However, the biological interaction between different types of particles was hardly studied.…”

mentioning

confidence: 99%

“…In the last 20 years, titanium (Ti) has evolved into one of the most widely used material for implant, tissue engineering, material for drug delivery and composite biomaterials, considered its outstanding mechanical properties 1,[13][14][15][16][17] . Nevertheless, Ti implants have some inherent disadvantages.…”

mentioning

confidence: 99%

“…Although the toxicity of Ti particle was proved 5,8,12 , and the Ti particles released from Ti bulk implant or composites was reported by lots of study 1,2,16,22 , it was inevitable to use Ti as an implant material, tissue engineering material, material for drug delivery or particle reinforced composite, considering its outstanding mechanical property 13,14,17 . Therefore, in this study, we are attempting to investigate the potential mechanisms of potential therapy for wear particles-induced osteolysis and explore the biological interaction between Ti and Al-NPs.…”

mentioning

confidence: 99%

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Nanosized Alumina Particle and Proteasome Inhibitor Bortezomib Prevented inflammation and Osteolysis Induced by Titanium Particle via Autophagy and NF-κB Signaling

Zhang

et al. 2020

Sci Rep

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Autophagy and nf-κB signaling are involving in the process of Particle Disease, which was caused by the particles released from friction interface of artificial joint, implant materials of particle reinforced composite, scaffolds for tissue engineering, or material for drug delivery. However, the biological interaction of different material particles and the mechanism of proteasome inhibitor, Bortezomib (BTZ), against Titanium (Ti) particle-induced Particle Disease remain unclear. In this study, we evaluated effect of nanosized Alumina (Al) particles and BTZ on reducing and treating the Ti particle-induced inflammatory reaction in MG-63 cells and mouse calvarial osteolysis model. We found that Al particles and BTZ could block apoptosis and NF-κB activation in osteoblasts in vitro and in a mouse model of calvarial resorption induced by Ti particles. We found that Al particles and BTZ attenuated the expression of inflammatory cytokines (IL-1β, IL-6, TNF-α). And Al prevented the IL-1β expression induced by ti via attenuating the nf-κB activation β-TRCP and reducing the expression of Casepase-3. Expressions of autophagy marker LC3 was activated in Ti group, and reduced by Al and/ not BTZ. Furthermore, the expressions of OPG were also higher in these groups than the Ti treated group. Collectively, nanosized Al could prevent autophagy and reduce the apoptosis, inflammatory and osteolysis induced by Ti particles. Our data offered a basic data for implant design when it was inevitable to use Ti as biomaterials, considering the outstanding mechanical propertie of Ti. What's more, proteasome inhibitor BTZ could be a potential therapy for wear particle-induced inflammation and osteogenic activity via regulating the activity of NF-κB signaling pathway.

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A caninein vitromodel for evaluation of marrow‐derived mesenchymal stromal cell‐based bone scaffolds

Gharat

Díaz‐Rodríguez

Erndt‐Marino

et al. 2018

J Biomedical Materials Res

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Tissue engineered bone grafts based on bone marrow mesenchymal stromal cells (MSCs) are being actively developed for craniomaxillofacial (CMF) applications. As for all tissue engineered implants, the bone-regenerating capacity of these MSC-based grafts must first be evaluated in animal models prior to human trials. Canine models have traditionally resulted in improved clinical translation of CMF grafts relative to other animal models. However, the utility of canine CMF models for evaluating MSC-based bone grafts rests on canine MSCs (cMSCs) responding in a similar manner to scaffold-based stimuli as human MSCs (hMSCs). Herein, cMSC and hMSC responses to polyethylene glycol (PEG)-based scaffolds were therefore compared in the presence or absence of osteoinductive polydimethylsiloxane (PDMS). Notably, the conjugation of PDMS to PEG-based constructs resulted in increases in both cMSC and hMSC osteopontin and calcium deposition. Based on these results, cMSCs were further used to assess the efficacy of tethered bone morphogenic protein 2 (BMP2) in enhancing PEG-PDMS scaffold osteoinductivity. Addition of low doses of tethered BMP2 (100 ng/mL) to PEG-PDMS systems increased cMSC expression of osterix and osteopontin compared to both PEG-PDMS and PEG-BMP2 controls. Furthermore, these increases were comparable to effects seen with up to five-times higher BMP2 doses noted in literature. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A:2382-2393, 2018.

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Nano-TiO2/PEEK bioactive composite as a bone substitute material: in vitro and in vivo studies

Cited by 65 publications

References 32 publications

Areas for use of PEEK material in dentistry

Areas for use of PEEK material in dentistry

Nanosized Alumina Particle and Proteasome Inhibitor Bortezomib Prevented inflammation and Osteolysis Induced by Titanium Particle via Autophagy and NF-κB Signaling

A caninein vitromodel for evaluation of marrow‐derived mesenchymal stromal cell‐based bone scaffolds

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