Micro- and nano-structured 3D printed titanium implants with a hydroxyapatite coating for improved osseointegration

Qin, Jie; Yang, Dongqing; Maher, Shaheer; Lima-Marques, Luis; Zhou, Yanmin; Chen, Yujie; Atkins, Gerald J.; Lošić, Dušan

doi:10.1039/c7tb03251j

Cited by 66 publications

(56 citation statements)

References 52 publications

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“…[ 25,39 ] However, nanotube layers on the underlying AM surface did not display any cracks and was in line with the previous study on AM titanium constructs. [ 21,22,38 ]…”

Section: Resultsmentioning

confidence: 99%

“…[ 65 ] Ideally, an optimal titanium implant surface would promote the osteogenic differentiation of host osteoprogenitor cells and then direct bone apposition, as opposed to fibroblastic cell morphology and resultant fibrous tissue encapsulation. [ 21,62,67 ] Cell proliferation and differentiation processes are expected to be an inverse relationship, that is, great differentiation usually coincides with reduced/arrested proliferation. [ 62 ] This is in line with our proliferation and differentiation results.…”

Section: Resultsmentioning

confidence: 99%

“…[ 64 ] Osteocalcin belongs to the class of non‐collagenous proteins and is considered as an osteoblast‐specific marker involved in osteogenic differentiation. [ 68 ] The increased expression of osteocalcin and Collagen I (Figure 6) by hMSCs on anodized surfaces was likely due to the physical cues offered by the hybrid micro‐/nano‐topographic surfaces, thereby promoting osteogenic differentiation of stem cells, [ 21,69 ] and importantly, this mechanism was not affected by the presence of MTANi (Figures 1C, 5G–I, and 6B,C; Figure S2E,F, Supporting Information). Xylenol orange binds to newly formed calcified nodules, which enables the monitoring of calcified deposits without being detrimental to cells.…”

Section: Resultsmentioning

confidence: 99%

“…The nanostructures are known to enhance osteogenesis as demonstrated in our previous study and can also be used as reservoirs for controlled drug delivery. [ 21–26,27 ] For combating infection, one of the attractive options is silver ions that have demonstrated a broad antimicrobial spectrum. [ 28,29 ] However, the toxicity of silver to eukaryotic cells, along with compromised osseointegration and inflammatory response, has been a concern.…”

Section: Introductionmentioning

confidence: 99%

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Combined Infection Control and Enhanced Osteogenic Differentiation Capacity on Additive Manufactured Ti‐6Al‐4V are Mediated via Titania Nanotube Delivery of Novel Biofilm Inhibitors

Mutreja

Hooper

et al. 2020

Adv Materials Inter

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Additive manufacturing (AM) of titanium alloys offers the capacity to fabricate patient-specific implants with defined porous architecture to enhance bone-implant fixation. However, clinical challenges associated with orthopedic implants include inconsistent osseointegration and biofilm-associated peri-implant infection, leading to implant failure. Here, a strategy is developed to reduce infection and promote osteogenesis simultaneously on AM Ti-6Al-4V implants by delivering biofilm inhibitor molecules via titania nanotube surface modification. Electrochemical anodization is performed on polished and as-manufactured Ti-6Al-4V to generate nanotubes, which are utilized for delivery of a novel methylthioadenosine nucleosidase inhibitor (MTANi) that targets MTAN-a key enzyme in bacterial metabolism involved in biofilm formation-thereby offering biofilm inhibition capacity combined with surface nano-topography for promoting osteogenesis. Clinical isolates of staphylococcus cohnii formed firm biofilms on polished and AM Ti-6Al-4V controls whereas modified implants loaded with MTANi inhibit biofilm formation. Anodized AM Ti-6Al-4V nanotube substrates enhance alkaline phosphatase production, bone-specific protein expression (osteocalcin, collagen I) and mineral deposition of human mesenchymal stromal cells (hMSCs), compared to as-manufactured controls. Importantly, no detrimental effects on hMSC proliferation and osteogenic differentiation are observed for MTANi-loaded substrates. Application of novel MTANi and electrochemical anodization offers a promising strategy for titanium alloy implant surface modification.

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“…[ 25,39 ] However, nanotube layers on the underlying AM surface did not display any cracks and was in line with the previous study on AM titanium constructs. [ 21,22,38 ]…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Combined Infection Control and Enhanced Osteogenic Differentiation Capacity on Additive Manufactured Ti‐6Al‐4V are Mediated via Titania Nanotube Delivery of Novel Biofilm Inhibitors

Mutreja

Hooper

et al. 2020

Adv Materials Inter

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“…The results were in‐line with our study that EDS analysis indicated higher amounts of Ca and P deposition on 3D printed anodized Ti6Al4V meshes compared with their non‐anodized counterparts. Qin et al printed square strips using Ti6Al4V powders and formed nanotubular features on these surfaces. Their results indicated enhanced in vitro osteocyte maturation compared with the non‐anodized surfaces.…”

Section: Resultsmentioning

confidence: 99%

Ti6Al4V foams having nanotubular surfaces for orthopaedic applications

İzmir

Tan

Ercan

2019

Surface & Interface Analysis

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Despite the widespread use of Ti6Al4V in orthopaedics, the bioinert nature of this alloy limits its biological fixation with the bone tissue. To enhance its bone fixation, two different types of Ti6Al4V foams were fabricated, and their surfaces were modified zto possess nanofeatures. To prepare the foams, spherical‐ or irregular‐shaped Ti6Al4V particles were used to form the backbones of the foams, while magnesium or carbamide powders were used as space holder agents. Once Ti6Al4V foams were fabricated, oxide‐based nanotubular arrays having 40 nm diameter were formed on the interconnected pore surfaces via anodization. Results showed successful growth of nanotubular oxide arrays independent of the pore surface morphology, chemistry, and porosity content. Nanotubular surfaces induced formation of calcium phosphate minerals independent of the Ti6Al4V particle type and the space holder agent. Thus, anodized nanotubular Ti6Al4V foams could potentially induce enhanced integration of Ti6Al4V‐based porous implants with the bone tissue.

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3D Printing and Digital Processing Techniques in Dentistry: A Review of Literature

et al. 2019

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In recent years, the rapid development of 3D printing technologies lead to its new applications in the area of healthcare and medicine, including dentistry, orthopedics, cardiovascular, pharmaceutics, neurosurgery, engineered tissue models, medical devices, and anatomical models. Dentistry is widely acknowledged to benefit from 3D printing technologies due to its needs for the customization and personalization of dental products. In this review, the authors discuss and summarize various 3D imaging technologies and the recent advances of 3D digital processing techniques in dentistry in an effort to give a new perspective and greater understanding of the current development of 3D printing technologies in dentistry. It is anticipated that this review will explore why 3D printing is important to dentistry, and why dentistry motivates development in 3D printing applications. Further, current challenges and further perspectives are also discussed which helps researchers to optimize the 3D printing technology in dentistry, improve 3D printing strategies, and direct future dental bioprinting and translational applications.

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Micro- and nano-structured 3D printed titanium implants with a hydroxyapatite coating for improved osseointegration

Abstract: 3D printing technology combined with electrochemical nano-structuring and HA modification is a promising approach for the fabrication of Ti implants with improved osseointegration.

Cited by 66 publications

References 52 publications

Combined Infection Control and Enhanced Osteogenic Differentiation Capacity on Additive Manufactured Ti‐6Al‐4V are Mediated via Titania Nanotube Delivery of Novel Biofilm Inhibitors

Combined Infection Control and Enhanced Osteogenic Differentiation Capacity on Additive Manufactured Ti‐6Al‐4V are Mediated via Titania Nanotube Delivery of Novel Biofilm Inhibitors

Ti6Al4V foams having nanotubular surfaces for orthopaedic applications

3D Printing and Digital Processing Techniques in Dentistry: A Review of Literature

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