Metronidazole-induced encephalopathy

Lala, Vikash G; Bobat, Bilal; Haagensen, Mark; Kathan, Prakash; Mahomed, Adam

doi:10.4102/sajr.v25i1.2016

Cited by 5 publications

(3 citation statements)

References 21 publications

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“…In multiple sclerosis, hyperintense signals on T2WI may be present in the periventricular, cortical, juxtacortical, infratentorial, and brain stem, with active lesions showcasing true restriction diffusion and contrast enhancement [ 20 ]. If the splenium shows T2-weighted hyperintensities, other conditions such as Marchiafava-Bignami, encephalitis, epilepsy, extrapontine osmotic demyelination, lupus erythematosus, renal failure, and cobalamin deficiency must be ruled out [ 21 ]. Heat stroke affects the thalami and external capsules, whereas cerebellar involvement is rare [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

MRI Findings and Topographic Distribution of Lesions in Metronidazole-Induced Encephalopathy

Fatima¹,

Khanduri²,

Sultana³

et al. 2022

Cureus

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Section: Discussionmentioning

confidence: 99%

MRI Findings and Topographic Distribution of Lesions in Metronidazole-Induced Encephalopathy

Fatima¹,

Khanduri²,

Sultana³

et al. 2022

Cureus

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“…5,6 Metronidazole merupakan antimikroba dan telah banyak digunakan sebagai antibakteri dan antiprotozoa untuk perawatan. 7 Metronidazole merupakan antimikroba yang telah digunakan sebagai perawatan tambahan untuk menghilangkan plak secara mekanis yaitu dengan scaling dan root planning. 8…”

Section: Pendahuluanunclassified

The Effectiveness of Metronidazole Gels in the Management of Periodontal Disease

Cangara,

Thahir

2024

interdental

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Introduction : Metronidazole is one of the antimicrobial and antimicrobial that has been widely used as antibacterial and antiprotozoal agent for treatment. Metronidazole is antimicrobial have been used as an adjuvant to mechanical plaque removal. Periodontal disease is a chronic inflammatory disease that develops from dental plaque that affects periodontal supporting tissues. Many chemical agents that have been evaluated to determine their effect on plaque, gingivitis and periodontitis, one of which is metronidazole, has been successfully introduced and studied extensively. This literature review explains effectiveness of metronidazole gels in the management of periodontal disease. Review : Metronidazole (MTZ) is frequently used in the treatment for periodontal diseases since it can be against several Gram-negative anaerobic rods, the pathogenesis of periodontitis. It can be administered via oral and topical routes. However, the systemic adverse effects may in the oral cavity if used peroral. Hence, topical administration is preferable. The bacterial reservoirs not eliminated by conventional periodontal therapy can be further suppressed with the use of chemotherapeutic agents. Localized antimicrobial therapy, in particular, has evoked growing interest because of the site‑specific nature of periodontal infections, the higher concentration of anti‑microbial agent subgingivally and reduced side‑effects of systemic antibiotic use. Among the various locally delivered chemotherapeutic agents metronidazole, a has bactericidal action against anaerobes, such as Prevotela intermedia, Porphyromonas gingivalis, Tannerella forsythia, Fusobacterium species and spirochetes like Treponema denticola, Treponema vincentii, which are generally believed to be the main pathogens associated with periodontitis. Conclusion : Treatment of periodontal pockets with metronidazole gel in addition to scaling and root planning, provides a significant increase in reducing pocket depth and microbial count and effective in the treatment of periodontal disease.

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“…1 It is crucial to optimize the dosage and duration of metronidazole use, as a prolonged period of administering more than 2 g/day is associated with peripheral neuropathy and cerebellar dysfunction. 2,3 Gut translocation of bacteria with clinically significant septic complications is common in bowel obstruction. In such cases, broad-spectrum antibiotics, including metronidazole, are frequently employed as an adjunct to surgery.…”

Section: Introductionmentioning

confidence: 99%

A case report of metronidazole-induced encephalopathy in a bowel obstruction patient with MRI findings

Katwal,

Katuwal,

Bhandari

2023

SAGE Open Medical Case Reports

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Metronidazole is a widely used antimicrobial agent in the treatment of anaerobic and protozoal infections. However, excessive and prolonged use of metronidazole can lead to encephalopathy. We present a case of a 69-year-old male with bowel obstruction who was treated with metronidazole for approximately 26 days and subsequently developed neurological signs and symptoms. The magnetic resonance imaging findings were consistent with the suspected diagnosis of metronidazole-induced encephalopathy. This case highlights the necessity for careful monitoring of patients receiving metronidazole to detect central nervous system toxicity, and emphasizes the role of magnetic resonance imaging in confirming the diagnosis.

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Metronidazole-induced encephalopathy

Cited by 5 publications

References 21 publications

MRI Findings and Topographic Distribution of Lesions in Metronidazole-Induced Encephalopathy

MRI Findings and Topographic Distribution of Lesions in Metronidazole-Induced Encephalopathy

The Effectiveness of Metronidazole Gels in the Management of Periodontal Disease

A case report of metronidazole-induced encephalopathy in a bowel obstruction patient with MRI findings

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